W. Wei

A bacterial genome and culture collection of gut microbial in weanling piglet

The paper establishes a bacterial genome and culture collection of the piglet gut microbiome, revealing new species and functional insights.

Botrytis cinerea BcPTP1 is a late infection phase, cysteine rich protein cytotoxic effector

This study identifies BcPTP1 as a phytotoxic effector secreted by Botrytis cinerea during late infection, which induces cell death and promotes lesion spreading.

A common SEC23B missense mutation in congenital dyserythropoietic anemia type II leads to growth restriction and chronic pancreatitis in mice

This study shows that a common SEC23B mutation in mice causes chronic pancreatitis and growth restriction, highlighting SEC23B's role in pancreatic function and growth hormone sensitivity.

Protein phosphatase 1 regulatory inhibitor subunit 14C promotes triple-negative breast cancer progression via sustaining inactive glycogen synthase kinase 3 beta

This study identifies PPP1R14C as a driver of triple-negative breast cancer progression by inactivating GSK3β through PP1 inhibition and TRIM25-mediated degradation of non-phosphorylated GSK3β.

Genome-wide CRISPR activation screen identifies novel receptors for SARS-CoV-2 entry

This study identifies novel SARS-CoV-2 receptors through a CRISPR activation screen, revealing LDLRAD3, TMEM30A, and CLEC4G as functional receptors independent of ACE2.

The Cdc42 GTPase activating protein Rga6 promotes the cortical localization of Septin

This study identifies Rga6 as a protein that promotes Septin complex localization to the cell cortex in fission yeast, supporting a model of polarized cell growth regulation.

Maxent modeling for predicting the potential distribution of global talaromycosis

This paper uses Maxent modeling to predict the global distribution of talaromycosis, identifying key environmental and epidemiological drivers.

Class I Histone Deacetylases (HDAC1-3) are Histone Lysine Delactylases

This study identifies HDAC1-3 and SIRT1-3 as enzymes that remove histone lactylation marks, contrasting with the known role of acetylation.

Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants

This paper develops a circular RNA vaccine encoding SARS-CoV-2 Spike RBD, showing broad protection against multiple variants including Delta and Omicron.

Case study of a rhizosphere microbiome assay on a bamboo rhizome with excessive shoots

The paper studies a rare bamboo rhizome phenomenon with excessive shoots, analyzing its associated microbiome and finding correlations between bacterial genera and shoot numbers.

Compositional analysis of ALS-linked stress granule-like structures reveals factors and cellular pathways dysregulated by mutant FUS under stress

This study compares the composition of normal stress granules and mutant FUS assemblies in stressed cells, identifying molecular differences and their impact on cellular stress responses in ALS-FUS.

Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents

This study analyzes evolutionary changes in Cdx2's DNA binding and transcriptional regulation between mice and rats, finding conserved transcriptional output despite divergent DNA binding.

Talaromyces marneffei promotes M2 polarization of human macrophages by downregulating SOCS3 expression and activating TLR9 pathway

This study shows Talaromyces marneffei induces M2 macrophage polarization by downregulating SOCS3 and activating TLR9, enhancing fungal survival.

Recombinant Fc-fusion vaccine of RBD induced protection against SARS-CoV-2 in non-human primate and mice

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

The female urinary microbiota in relation to the reproductive tract microbiota

The study analyzes the urinary microbiota of 147 Chinese women, revealing non-sterile urine with distinct bacterial communities and showing similarity to cervical and uterine microbiota rather than vaginal microbiota.

Cell type-selective secretome profiling in vivo

The paper introduces a method to profile cell-type-specific secretomes in vivo and identifies novel secreted proteins and dynamic changes in hepatocyte secretomes.

Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.

Combined transient ablation and single cell RNA sequencing reveals the development of medullary thymic epithelial cells

The paper uses transient ablation and single-cell RNA sequencing to study mTEC development, revealing a transit-amplifying population preceding Aire expression and a branching model of differentiation.

Resolving an underrepresented circulating tumor cell population in lung cancer enabled by Hexokinase 2 analysis

This study identifies HK2 as a marker for detecting underrepresented CTCs in NSCLC, revealing a distinct subpopulation with unique characteristics.

Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism

This study shows that lysosomal activity in C. elegans regulates mitochondrial fission through vitamin B12 metabolism, linking lysosomal dysfunction to mitochondrial dynamics and micronutrient deficiency.

Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer

This paper develops a genetically defined, syngeneic organoid platform for ovarian cancer to evaluate combination therapies and finds genotype-specific responses to immunotherapy and chemotherapy.

Identification of 2019-nCoV related coronaviruses in Malayan pangolins in southern China

The paper identifies 2019-nCoV related coronaviruses in Malayan pangolins, suggesting they may be intermediate hosts for the virus.

P4HA2 is associated with prognosis, promotes proliferation, invasion, migration and EMT in glioma

This study shows P4HA2 is overexpressed in glioma and promotes cancer progression by enhancing proliferation, invasion, migration, and EMT, while also regulating the PI3K/AKT pathway through collagen expression.

A global map of root biomass across the world's forests

The paper creates a high-resolution global root biomass map using field measurements and environmental data, finding lower root biomass than previous studies due to improved methods and data.

Trajectories from Snapshots: Integrated proteomic and metabolic single-cell assays reveal multiple independent adaptive responses to drug tolerance in a BRAF-mutant melanoma cell line

The paper uses integrated proteomic and metabolic single-cell assays to identify two distinct adaptive pathways in BRAF-mutant melanoma cells during drug treatment.

Genome-wide analysis of GATA factors in moso bamboo (Phyllostachys edulis) unveils that PeGATAs regulate shoot rapid-growth and rhizome development

This study identifies PeGATA transcription factors in moso bamboo and shows they regulate shoot growth and rhizome development via GA signaling pathway.

A Single-Cell Immune Atlas of Triple Negative Breast Cancer Reveals Novel Immune Cell Subsets

The paper performs single-cell RNA sequencing on TNBC tumors to identify novel immune cell subsets and their associations with survival and TCR signaling.

The full-length transcriptome of Spartina alterniflora reveals the complexity of high salt tolerance in monocotyledonous halophyte

This study uses full-length transcriptome sequencing to analyze salt tolerance mechanisms in Spartina alterniflora and identifies key genes and regulatory networks involved in stress response.

Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy

The paper identifies a pathway where Golgi localized β1-adrenergic receptors stimulate PI4P hydrolysis via PLCε to promote cardiac hypertrophy, distinct from surface receptor signaling.

Internal Tensile Force and A2 Domain Unfolding of von Willebrand Factor Multimers in Shear Flow

This study uses simulations to show that A2 domain unfolding in vWF multimers under shear flow occurs preferentially near the center of unraveled multimers, with threshold shear rates inversely related to multimer length.