metabolomics

DTH1-dependent remodeling of the lipid and protein environment of lipid droplets during nutrient recovery in Chlamydomonas

This study investigates the role of DTH1 in remodeling lipid and protein environments of lipid droplets during nutrient recovery in Chlamydomonas, revealing its impact on lipid degradation and organelle communication.

Peripheral microbial metabolites as indicators of gut microbiome disruption: systematic review and meta-analysis

This study identifies peripheral microbial metabolites as indicators of gut microbiome disruption, showing they can distinguish microbiome states with performance comparable to direct sequencing.

Functional characterization of terpene synthases from Dendrobium nobile provides insights into the biosynthesis of copaborneol, a proposed dendrobine precursor

The paper functionally characterizes terpene synthases in Dendrobium nobile to identify copaborneol production and residues affecting product selectivity.

β-cyclocitral elicits rapid signaling distinct from the excess-light response in Arabidopsis

This study shows that β-cyclocitral triggers rapid cellular responses in Arabidopsis, distinct from the delayed transcriptional changes associated with excess light stress.

Desktop iDMS: A stand-alone application of intelligent differential mobility spectrometry (iDMS), a neural net-work that predicts optimal separation and compensa-tion voltages for field asymmetric differential ion mobil-ity spectrometry

The paper introduces iDMS, a neural network that predicts optimal separation and compensation voltages for DMS, improving glycosphingolipid analysis.

Acute Metabolic Switch by High-Dose Dehydroascorbic Acid: Rapid TCA Cycle Depletion and Early Signature of Methionine Trap within 1 Hour in KRAS-Mutant Cells

Rapid isothermal amplification of the diatom RuBisCO gene from eDNA and eRNA reveals their abundance and photosynthetic physiology

The paper develops a rapid qRPA assay to quantify diatom rbcL DNA and RNA from eDNA/eRNA, revealing abundance and photosynthetic activity in marine environments.

Unveiling Lipid Dysregulation: Lipidomics of Mouse Brain and Isolated Myelin in Niemann - Pick Disease Type C1

This study identifies region-specific lipid dysregulation in the cerebellum and cortex of Npc1-/- mice and myelin, revealing novel lipid alterations linked to NPC1 disease.

Biosensor-guided evolution of chalcone synthase enhances biosynthesis of natural and non-natural flavanones

The paper improves microbial production of diverse flavanones by evolving chalcone synthases using a biosensor-based screening approach.

Sphingolipid-Driven Lipotoxicity Promotes Calcific Aortic Valve Disease Through ER-Stress-NF-κB-EndMT Signaling and Is Therapeutically Targetable Through Serine Palmitoyltransferase Inhibition

This study identifies ceramide-driven lipotoxicity as a driver of calcific aortic valve disease and shows that SPT inhibition can reverse disease progression in vivo.

Gut microbiota-derived indole-3-propionic acid preserves dorsal hippocampal catecholamines to prevent post-stroke cognitive impairment

This study identifies indole-3-propionic acid (IPA) as a gut microbiota-derived metabolite that prevents post-stroke cognitive impairment by preserving catecholamines in the dorsal hippocampus.

Diet-conditioned microbiota enhances fecal microbiota transplantation efficacy in alcoholic liver disease through caproic acid-PPARα signaling

This study shows that a high-protein donor diet enhances fecal microbiota transplantation efficacy in alcoholic liver disease by increasing caproic acid and PPARα signaling.

The protective effect of NGF mutant CHF6467 in SH SY5Y cells exposed to Aβ(1-42): a pharmacometabolomic approach

This study uses NMR-metabolomics to show CHF6467 mitigates Aβ(1-42)-induced metabolic changes in SH-SY5Y cells by promoting phospholipid precursors, reducing glutamate excitotoxicity, and restoring energy metabolism.

KRAS-driven metabolic reprogramming of enhanced MFSD2A-mediated lysophosphatidylcholine scavenging promotes survival and progression of pancreatic ductal adenocarcinoma

This study identifies KRAS-driven metabolic reprogramming through MFSD2A-mediated lysophosphatidylcholine scavenging as a driver of PDAC progression and shows that targeting this pathway with edelfosine has anti-cancer effects.

From acidic extreme environments to agriculture: a multi-stress-tolerant Talaromyces pseudofuniculosus enhances soybean growth under abiotic stress

This study identifies a stress-tolerant fungus that enhances soybean growth under abiotic stress conditions.

Sex-Dependent Microbiome-Metabolome Remodeling Associated with Bacteroides acidifaciens Modulation of Acute Respiratory Distress Syndrome

This study investigates sex-dependent microbiome and metabolome changes in mice with ARDS induced by Bacteroides acidifaciens, finding distinct metabolic and microbial responses in males and females.

Closed-head injury produces a delayed, region-specific defect in glucose-carbon routing at the pyruvate branchpoint in APP/PS1 KI mice

The paper investigates delayed glucose metabolism changes in APP/PS1 KI mice after closed-head injury, finding increased pyruvate and lactate labeling in cortex and hippocampus 8 months post-injury.

Metabolic commitment to human motor neurons is characterized by mitochondrial depletion and pyruvate rewiring

The paper characterizes metabolic changes in human motor neuron differentiation, showing mitochondrial depletion and a shift in pyruvate metabolism.

Lactate Dehydrogenase Activity and Carbohydrate Metabolism under Vanadium Citrate Exposure: Sex- and Dose-Dependent Effects in Rat Tissues

A microbiota-dependent gut bile acid axis links germline mutant p53 to distal tumour growth.

This study shows that mutant p53 alters gut microbiota interactions, leading to bile acid changes that promote distal tumour growth.

Mucosal architecture, microbiota resilience and metabolic disruption reveal holobiont dynamics during bovine respiratory disease

This study investigates host-microbiota interactions during bovine respiratory disease, finding that antimicrobial treatment has a greater impact on microbial communities and metabolic functions than infection alone.

Assay coverage reshapes metabolic diagnosis and the interpretation of pathway disturbance

The paper analyzes metabolic profiles across Arabidopsis and human datasets to show how assay coverage affects diagnostic accuracy and pathway interpretation.

Mycobacterium tuberculosis inactivates host oxysterols to impair macrophage cholesterol homeostasis

This study identifies Mtb's enzymatic inactivation of host oxysterols as a mechanism to disrupt macrophage cholesterol homeostasis and generate treatment-responsive metabolic signatures in TB.

Deciphering efficient metabolic pathways in an anaerobic gut fungus coupled with a syntrophic methanogen

This study investigates metabolic pathways in anaerobic gut fungi and their syntrophic methanogen partners using 13C-glucose and supplements, revealing key metabolic contributions and growth effects.

Organizing principles of the cellular electron economy

The paper introduces the concept of the cellular electron economy to quantify and organize electron flow across metabolism in microorganisms, revealing how carbon sources and electron disposal capacity shape metabolic organization.

Autoinducer-2 functions as both a quorum sensing and metabolic signal in Escherichia coli

This study shows AI-2 functions as both a quorum sensing and metabolic signal in E. coli, linking nutrient sensing to population-level signaling through CRP and the lsr operon.

Restoring Antibiotic Sensitivity via Metabolic Pathway Manipulation in Pseudomonas aeruginosa

The paper shows that combining biotin biosynthesis inhibition with metformin reduces Pseudomonas aeruginosa virulence and restores antibiotic sensitivity by targeting metabolic pathways.

A Novel ACLY Inhibitor Induces Transcriptional and Metabolic Reprogramming to Overcome Tyrosine kinase inhibitor Resistance in Lymphoma

This paper identifies VCB1, a novel ACLY inhibitor, which overcomes TKI resistance in lymphoma by disrupting lipid and nucleotide metabolism, ISR, and redox homeostasis.

Novel modifications to fructose metabolism are associated with adaptation to high-sugar diets in bats

This study identifies metabolic adaptations in bats with high-sugar diets, showing that fructose metabolism is prioritized over glucose metabolism to avoid disease.

Two Genomes, One Metabolome: Mitonuclear Incompatibility Remodels Developmental Metabolism and Fitness in Drosophila

This study shows that mitonuclear incompatibility in Drosophila leads to metabolic remodeling and reduced fitness traits such as body size and development speed.