multiome

An optimal transport-based low-dimensional visualization framework for high-parameter flow cytometry

This paper introduces an optimal transport-based framework for visualizing high-parameter flow cytometry data, providing biologically consistent layouts and enabling quantitative analysis of population changes.

Moderate-Intensity Intermittent Training Inhibits miR-34a-5p to Reduce Prefrontal Cortex Apoptosis and Improve Cognitive Ability in Aging Rats Reduced by D-galactose

This study shows that moderate-intensity intermittent training reduces miR-34a-5p expression, decreases apoptosis, and improves cognitive function in D-galactose-induced aging rats.

Employing Artificial Neural Networks for Optimal Storage and Facile Sharing of Molecular Dynamics Simulation Trajectories

This paper develops a method using AutoEncoders to compress Molecular Dynamics trajectories, achieving 98% space reduction while maintaining accurate reconstruction of atom coordinates.

FICD deficiency protects mice from hypertrophy-induced heart failure via BiP-mediated activation of the UPRER and ER-phagy

This study shows that FICD deficiency protects mice from heart failure by enhancing BiP-mediated UPRER and ER-phagy under stress.

Dose-dependent interferon programs in myeloid cells after mRNA and adenovirus COVID-19 vaccination

This study compares immune responses to different COVID-19 vaccines in humans, finding distinct interferon programs in myeloid cells based on vaccine type and dose timing.

Insights into the Translational Activation Mechanisms of the COX1 mRNA in Yeast Mitochondria

The paper investigates the translational activation mechanisms of COX1 mRNA in yeast mitochondria, revealing that Pet309 and Mss51 interact with the mitoribosome independently of active translation.

Development of Emerin mRNA Lipid Nanoparticles to Rescue Myogenic Differentiation

This study develops emerin mRNA lipid nanoparticles (EMD-LNPs) to restore emerin protein expression in emerin-null myogenic progenitors, improving differentiation and showing low toxicity.

Multi-level repression ensures tight translation control of C9ORF72

The paper investigates the multi-layered repression system controlling C9ORF72 translation and identifies strategies to rescue loss-of-function in disease.

Robust Estimation of Rotational Diffusion Tensors of Proteins from Molecular Dynamics Simulations

This paper develops a method to estimate rotational diffusion tensors of proteins from MD simulations and validates it using BD simulations, finding ubiquitin exhibits nearly semi-isotropic diffusion.

Change of Guards: ELAVL Proteins Switch miRNA Export Responsibility to Regulate Neuronal Differentiation

The paper shows that HuD replaces HuR in regulating miRNA export during neuronal differentiation, promoting differentiation by altering miRNA activity.

Complementary MR measures of white matter and their relation to cardiovascular health and cognition

The paper identifies latent factors underlying white matter metrics using MRI data from a cohort of healthy adults and links these factors to cardiovascular health and cognitive performance.

Isolation and Quantification of mRNAs from Subcellular Phase-Separated Structures from Detergent Permeabilized Brain Cells

This paper isolates and quantifies mRNAs from subcellular phase-separated structures in brain cells to study how amyloid proteins affect mRNA dynamics in neurons and glial cells.

Testing the plasticity-first theory of tumor evolution with spatiotemporal lineage tracing

This study uses lineage tracing and single-cell analysis to show tumor plasticity precedes stable immune evasion, with AP-1 regulating EMT stabilization during immunotherapy.

Cocaine use disorder is associated with lower brain state transition energy particularly in higher order and excitatory networks

This study finds that cocaine use disorder is linked to reduced brain state transition energy in specific networks, particularly those involved in excitatory and higher-order functions.

An IFN-STAT1-CYBB Axis Defines Protective Plasmacytoid DC to Neutrophil Crosstalk During Aspergillus fumigatus Infection.

The paper identifies an IFN-STAT1-CYBB axis that mediates protective crosstalk between plasmacytoid dendritic cells and neutrophils during Aspergillus fumigatus infection.

Evaluating Labelling Efficiency of Commercial SPIONs in Mesenchymal Stem/Stromal Cells for Magnetic Particle Imaging Applications

This study evaluates the labelling efficiency and MPI performance of four commercial SPIONs in mouse mesenchymal stem/stromal cells, identifying ProMag and VivoTrax as optimal candidates for MPI-based tracking.

Towards an informed choice of diffusion MRI image contrasts for cerebellar segmentation

This study evaluates diffusion MRI contrasts for cerebellar segmentation, finding that spherical mean images outperform traditional microstructure maps.

Single-cell multiomics reveals the oscillatory dynamics of mRNA metabolism and chromatin accessibility during the cell cycle

The paper uses single-cell multiomics to analyze mRNA metabolism and chromatin accessibility dynamics during the cell cycle, revealing oscillatory patterns and regulatory mechanisms.

Lipid nanoparticle delivered intrabodies for inhibiting necroptosis and pyroptosis

This paper uses lipid nanoparticles to deliver mRNA encoding intrabodies that inhibit necroptosis and pyroptosis by targeting MLKL and ASC, respectively.

Multimodal analyses reveal genes driving electrophysiological maturation of neurons in the primate prefrontal cortex

The paper identifies genes and regulatory networks driving electrophysiological maturation of neurons in primate prefrontal cortex, with implications for autism.

The GSA Family in 2025: A Broadened Sharing Platform for Multi-Omics and Multimodal Data

The paper introduces the GSA Family, a platform for sharing multi-omics and multimodal data, with expanded databases and improved features.

Iterative delivery of mRNA by MEFI

This paper introduces MEFI, a platform for iterative mRNA delivery that enhances expression and cross-organ transfer in mice.

Dual Targeting of MAPK Signaling and Senescence-Associated Survival Pathways Overcomes Vincristine Resistance in Fusion-Negative Rhabdomyosarcoma

This paper identifies MAPK signaling and MYC-driven suppression of p21 as mechanisms of vincristine resistance in fusion-negative rhabdomyosarcoma and shows that dual targeting of MAPK and BCL-XL pathways overcomes resistance.

Intracellular auto-circularizing RNA using human tRNA splicing elements

This study identifies human tRNA splicing elements that enable efficient intracellular auto-circularization of RNA, providing a framework for circRNA production.

MOTL: enhancing multi-omics matrix factorization with transfer learning

MOTL improves multi-omics data factorization for small datasets by transferring knowledge from large datasets, enhancing cancer subtype identification in glioblastoma samples.

Nuclear RNA cap-chaperones eIF4E and NCBP2 influence distinct mRNA fates

The paper shows eIF4E and NCBP2 have distinct roles in nuclear mRNA processing, influencing different transcript populations and outcomes.

Molecular basis of the autoregulatory mechanism of motor neuron-related splicing factor 30

This study identifies the molecular mechanism by which SPF30 autoregulates its expression through alternative splicing and nonsense-mediated decay.

Sequential cold and heat stresses establish an intergenerational stress memory in rapeseed (Brassica napus L.)

This study shows that sequential cold and heat stress in rapeseed improves immediate stress tolerance and induces heritable metabolic and physiological changes in the next generation.

De novo administration of antiviral monoclonal antibodies against SARS-CoV-2 or influenza using mRNA lipid nanoparticles

This study compares traditional mAb infusion with mRNA/LNP-based de novo mAb expression in mice, finding high serum concentrations but compromised protective capacity due to anti-drug antibodies.

Early lineage divergence segregates sensory and non-sensory thalamic circuits

The paper generates a single-cell multiomic atlas of the embryonic mouse thalamus, identifies two major glutamatergic lineages, and reveals early lineage divergence that segregates sensory and non-sensory circuits.