Schizophrenia research and treatment

Blocking Src-PSD-95 interaction rescues glutamatergic signaling dysregulation in schizophrenia.

This study shows that blocking the Src-PSD-95 interaction with a peptide rescues NMDAR hypofunction and improves behavioral deficits in schizophrenia models.

External Cues Improve Visual Working Memory Encoding in the Presence of Salient Distractors in Schizophrenia

This study shows that external cues improve visual working memory in schizophrenia when salient distractors are present, suggesting preserved top-down attention guidance despite attentional control deficits.

Attention-mediated genetic influences on psychotic symptomatology in adolescence

The paper examines how genetic risk scores relate to attentional variability and psychotic-like experiences in adolescents, finding partial mediation through attentional variability.

Causal Discovery Analysis Reveals Insights into Psychosis Proneness, Brain Function, and Environmental Factors among Young Individuals

The paper uses causal discovery analysis to identify causal relationships among factors contributing to psychosis proneness in young individuals, finding negative self-schema and social cohesion as key factors.

Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study

This study investigates how structural brain alterations in schizophrenia relate to network architecture, finding hub susceptibility and shared epicenters across disease stages and disorders.

MSK1 absence hinders BDNF-dependent striatal neurodevelopment and leads to schizophrenia symptoms

This study shows that MSK1 absence disrupts BDNF-dependent striatal development and leads to schizophrenia-like behaviors in mice.

Enhancement of mediodorsal thalamus rescues aberrant belief dynamics in a mouse model with schizophrenia-associated mutation.

This study identifies the mediodorsal thalamus as critical for belief dynamics in a schizophrenia mouse model and shows that enhancing its activity rescues cognitive deficits.

Disruption of consciousness depends on insight in OCD and on positive symptoms in schizophrenia

This study examines how insight and psychotic symptoms relate to consciousness disruption in schizophrenia and OCD, identifying distinct subgroups based on symptomatology and cognitive function.

Variability in white matter structure relates to hallucination proneness

This study links hallucination proneness to structural white matter variability in healthy individuals using diffusion tensor imaging.

Cortical Network Disruption is Minimal in Early Stages of Psychosis

The paper investigates white matter and cortical network changes in early psychosis and finds minimal disruption in first-episode psychosis compared to chronic patients and controls.

Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia

The paper identifies epigenetic changes in frontal cortex of schizophrenia patients, showing antipsychotic treatment reverses some alterations and amplifies age effects.

Adolescent stress-induced ventral hippocampus redox dysregulation underlies behavioral deficits and excitatory/inhibitory imbalance related to schizophrenia

This study shows that adolescent stress disrupts ventral hippocampus redox balance and mitochondrial function, leading to behavioral and neural abnormalities linked to schizophrenia.

A multistage, dual voxel study of glutamate in the anterior cingulate cortex in schizophrenia supports a primary pyramidal dysfunction model of disorganization

The paper investigates glutamate levels in the anterior cingulate cortex across different schizophrenia risk stages, finding reduced glutamate in genetic high risk and higher glutamate in clinical high risk, linking glutamate changes to disorganization symptoms.

A miR-137-related biological pathway of risk for Schizophrenia is associated with human brain emotion processing

The paper links miR-137 and its target genes to schizophrenia risk through emotion processing in the prefrontal cortex, showing allele associations with brain activation patterns.

Bayesian Accounts of Perceptual Decisions in the Nonclinical Continuum of Psychosis: Greater Imprecision in Both Top-down and Bottom-up Processes

This study uses Bayesian modeling to show that psychotic-like experiences are linked to reduced precision in prior information and increased noise in sensory processing, supporting both weaker bottom-up and top-down perceptual processes.

Plasma neurofilament light protein provides evidence of accelerated brain ageing in treatment-resistant schizophrenia

The paper examines if plasma NfL levels correlate with age differently in psychiatric disorders compared to healthy individuals, finding accelerated brain aging in treatment-resistant schizophrenia.

Evidence for impaired hippocampal circuitry in schizophrenia and its link to memory dysfunction

This study investigates hippocampal circuitry impairments in schizophrenia, finding deficits in pattern separation and completion linked to memory dysfunction and delusions, with antipsychotic treatment showing normalization of neural activity.

Effect of Schizophrenia linked DRD2 gene mutations and correlation of social behavior with biochemical changes in a post-weaning isolated mouse model

Screening of the Key Genes and Signaling Pathways for Schizophrenia Using Bioinformatics and Next Generation Sequencing Data Analysis

This study identifies key genes and pathways in schizophrenia using bioinformatics and NGS data analysis of neural progenitor cells and neurons from healthy controls and schizophrenia patients.

Estimating multimodal brain variability in schizophrenia spectrum disorders: A worldwide ENIGMA study

This study examines structural brain heterogeneity in schizophrenia using multimodal MRI data from the ENIGMA dataset, finding higher frontotemporal heterogeneity and left parahippocampal homogeneity in patients.

Dopamine and schizophrenia from bench to bedside: Discovery of a striatal co-expression risk gene set that predicts in vivo measures of striatal function.

The paper identifies a striatal gene set linked to schizophrenia risk that predicts in vivo dopamine synthesis and striatal activation in neurotypical and patient cohorts.

Dysfunctional parvalbumin interneurons in a genetic mouse model of schizophrenia

This study investigates hyperexcitability of parvalbumin interneurons in the hippocampus of a 22q11DS mouse model and identifies Kv1.1 channel dysfunction as a contributing factor.

Working memory-related activity in catecholaminergic nuclei in schizophrenia

This study examines catecholaminergic nuclei activation during working memory tasks in schizophrenia, finding reduced activation at high cognitive load in patients compared to controls.

Lateral Septal Circuits Govern Schizophrenia-Like Effects of Ketamine on Social Behavior

This study identifies the lateral septum as a key circuit involved in ketamine-induced social deficits, showing that its hypoactivation contributes to schizophrenia-like behaviors.

Developmental changes in cerebral NAD and neuroenergetics of an antioxidant compromised mouse model of schizophrenia

This study examines developmental changes in NAD redox state and neuroenergetics in a schizophrenia mouse model with compromised antioxidant capacity, identifying altered metabolite levels and potential therapeutic targets.

Reduced mammillary body volume in individuals with a schizophrenia diagnosis: an analysis of the COBRE data set

The paper analyzes mammillary body volume in schizophrenia patients using the COBRE dataset and finds reduced volume after controlling for brain size and gender.

Qualitatively different delay-dependent working memory distortions in people with schizophrenia and healthy control subjects

This study compares working memory dynamics in schizophrenia patients and healthy controls, finding distinct drift patterns in memory representations during delayed-response tasks.

Cell type and condition specific functional annotation of schizophrenia associated non-coding genetic variants

The paper functionally annotates schizophrenia-associated non-coding variants by identifying cell type and condition specific molecular functions and target genes.

Alprazolam modulates persistence energy during emotion processing in first-degree relatives of individuals with schizophrenia: a network control study

This study uses network control theory to examine how alprazolam affects persistence energy during emotion processing in schizophrenia relatives, revealing compensatory mechanisms and neuromodulatory relationships.

Aperiodic neural activity is a better predictor of schizophrenia than neural oscillations

This study shows that aperiodic neural activity, not oscillatory power, better predicts schizophrenia diagnosis and severity using EEG data during a target detection task.