Schizophrenia research and treatment

Identifying modifiable comorbidities of schizophrenia by integrating electronic health records and polygenic risk

This study identifies modifiable comorbidities of schizophrenia by analyzing EHR data and polygenic risk scores, finding conditions with no shared genetic risk that may be influenced by treatment or environment.

A marker chromosome in psychosis identifies glycine decarboxylase (GLDC) as a novel regulator of neuronal and synaptic function in the hippocampus

The mitochondrial matrix protein cyclophilin D contributes to deficits in parvalbumin interneurons in schizophrenia

The paper investigates cyclophilin D (CypD) alterations in parvalbumin interneurons (PVIs) in schizophrenia, linking CypD to redox dysregulation and PVI dysfunction.

Neural mechanisms underlying release-mode-specific abnormalities in dopamine neural activity in a schizophrenia-like model

This paper investigates dopamine release mode abnormalities in a schizophrenia-like model and identifies mechanisms involving serotonergic regulation and antipsychotic effects.

Deep proteomics identifies shared molecular pathway alterations in synapses of schizophrenia and bipolar disorder patients and mouse model

Using brain cell-type-specific protein interactomes to interpret genetic data in schizophrenia

The paper uses brain cell-type-specific protein interactomes to interpret genetic data in schizophrenia and identifies enriched networks and genes associated with the disease.

Non-additive effects of schizophrenia risk genes reflect convergent downstream function

The paper shows that non-additive effects of schizophrenia risk genes are due to convergent downstream transcriptomic effects and sub-additive changes, suggesting functional redundancy as a mechanism for non-additivity.

Unraveling the role of Slc10a4 in auditory processing and sensory motor gating: implications for neuropsychiatric disorders?

This study examines Slc10a4 knockout mice to assess their role in auditory processing and sensory motor gating, suggesting they may model neuropsychiatric disorders like schizophrenia.

Activation of prefrontal parvalbumin interneurons ameliorates treatment-resistant working memory deficit even under continuous antipsychotic treatment in a mouse model of schizophrenia

This study shows that activating prefrontal parvalbumin interneurons improves working memory deficits in a mouse model of schizophrenia, even when mice are continuously treated with antipsychotics.

Longitudinal changes in brain metabolites in healthy subjects and patients with first episode psychosis (FEP): a 7-Tesla MRS study

This study uses 7-Tesla MRS to track longitudinal changes in brain metabolites in FEP patients and healthy controls, identifying potential trait and state markers for psychosis.

The role of optogenetic stimulations of parvalbumin-positive interneurons in the prefrontal cortex and the ventral hippocampus on an acute MK801 model of schizophrenia-like cognitive inflexibility

This study investigates how optogenetic stimulation of parvalbumin-positive interneurons in the prefrontal cortex and ventral hippocampus can rescue cognitive inflexibility induced by dizocilpine in rats.

Normative modeling of brain morphometry in Clinical High-Risk for Psychosis

This study examines brain morphometric deviations in individuals at clinical high-risk for psychosis and finds they largely overlap with healthy variation and are not strongly associated with symptom severity or conversion to psychosis.

Neural substrates of cognitive impairment in a NMDAR hypofunction mouse model of schizophrenia and rescue by risperidone

This study investigates the neural mechanisms of cognitive impairment in a schizophrenia mouse model and shows that risperidone rescues memory and auditory perception deficits by restoring mPFC-dHPC connectivity.

Persistent Extrasynaptic Hyperdopaminergia in the mouse Hippocampus Induces Plasticity and Recognition Memory Deficits Reversed by Antipsychotics

This study shows that chronic dopamine transporter blockade in the mouse hippocampus causes learning and memory deficits, which are partially reversed by D2 receptor antagonists.

Candidates for Drug Repurposing to Address the Cognitive Symptoms in Schizophrenia

The paper identifies eight drug candidates for repurposing to treat cognitive symptoms in schizophrenia, with sex-specific recommendations based on gene expression differences.

Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience.

This study shows that GluA1 dysfunction leads to impaired short-term habituation, resulting in a hyper-dopaminergic phenotype in the nucleus accumbens, which may contribute to aberrant salience in schizophrenia.

Integrative analysis to identify shared mechanisms between schizophrenia and bipolar disorder and their comorbidities

This study identifies shared genetic and biological mechanisms between schizophrenia, bipolar disorder, and type 2 diabetes mellitus using integrative analysis of gene expression datasets.

Current progress in understanding Schizophrenia using genomics and pluripotent stem cells: A Meta-analytical overview

This paper reviews genomic studies and iPSC-based models of schizophrenia to summarize current progress in understanding its genetic basis and cellular mechanisms.

Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice

This study identifies brain region-specific changes and dopamine dysregulation in Grin2a mutant mice, supporting schizophrenia hypotheses and highlighting their utility as a genetic model.

Selective Nigrostriatal Dopamine Excess Impairs Behaviors Linked to the Cognitive and Negative Symptoms of Psychosis

This study shows that selectively increasing dopamine in the dorsal striatum impairs behaviors linked to negative and cognitive symptoms of psychosis, challenging the idea that excess dopamine is not involved in these symptoms.

The miR-124-AMPAR pathway connects polygenic risks with behavioral changes shared between schizophrenia and bipolar disorder

This study identifies the miR-124-AMPAR pathway as a common mediator linking polygenic risks to shared behavioral changes in schizophrenia and bipolar disorder.

Linking Choroid Plexus Enlargement with Plasma Analyte and Structural Phenotypes in Clinical High Risk for Psychosis: A Multisite Neuroimaging Study

This study finds that individuals at clinical high risk for psychosis have larger choroid plexus volumes, associated with neuroanatomical changes and plasma analyte markers.

Selective vulnerability of supragranular layer neurons in schizophrenia

The paper identifies selective vulnerability of supragranular layer neurons in schizophrenia through single nucleus RNA sequencing and histological analysis.

Transcriptional and genetic sex differences for schizophrenia across the dorsolateral prefrontal cortex, hippocampus, and caudate nucleus

The paper identifies sex differences in schizophrenia across three brain regions using RNA-seq and genotypes, finding sex-specific genes, eQTLs, and transcriptional features.

Schizophrenia polygenic risk during typical development reflects multiscale cortical organization

This study links schizophrenia polygenic risk to cortical thickness changes in developing children, showing a trajectory toward adult schizophrenia patterns.

Affinity Scores: An Individual-centric Fingerprinting Framework for Neuropsychiatric Disorders

The paper introduces a framework to identify individual-specific biopsychosocial fingerprints for neuropsychiatric disorders using affinity scores, achieving high classification accuracy.

Identification of activity-induced Egr3-dependent genes reveals genes associated with DNA damage response and schizophrenia

The paper identifies Egr3-dependent genes in mice hippocampi after ECS, finding genes related to DNA damage response and schizophrenia.

Pathway-based polygenic risk scores for schizophrenia and associations with clinical and neuroimaging phenotypes in UK Biobank

This study calculates pathway-based polygenic risk scores for schizophrenia using gene-sets related to synaptic function and histone modification, and finds associations with neuroimaging and clinical traits in UK Biobank.

The positive dimension of schizotypy is associated with a reduced attenuation and precision of self-generated touch

This study finds that higher positive schizotypal traits are linked to reduced somatosensory attenuation and precision for self-generated touch.

Clinical features of UK Biobank subjects carrying protein truncating variants in genes implicated in schizophrenia pathogenesis

The paper examines UK Biobank participants with protein truncating variants in schizophrenia-associated genes, finding limited psychiatric symptoms despite increased risk.