Schizophrenia research and treatment

Analysis of exome sequencing data implicates rare coding variants in STAG1 and ZNF136 in schizophrenia

This study identifies rare coding variants in STAG1 and ZNF136 associated with schizophrenia using exome sequencing data from 28,898 cases and 103,041 controls.

Muti-omics characterization reveals brain-wide disruption of synapses and region- and age-specific changes in neurons and glia in Sp4 mutant mice, a genetic model of schizophrenia and bipolar disorder

This study uses multi-omics analyses of Sp4 mutant mice to reveal synapse disruption and age- and region-specific neuronal and glial changes linked to schizophrenia and bipolar disorder.

SRRM2 haploinsufficiency drives SynGAP-γ reduction, Agap3 mis-splicing, and oligodendrocyte deficits in a mouse model of schizophrenia

This study shows that SRRM2 haploinsufficiency in mice causes synaptic, splicing, and myelination defects linked to schizophrenia-like behaviors and gene expression changes.

Spontaneous brain activity and synaptic density in schizophrenia: a combined UCB-J PET and fMRI study

This study investigates the relationship between spontaneous brain activity (ALFF) and presynaptic density (measured by [11C]UCB-J PET) in schizophrenia, finding group differences in their correlation.

Individual Differences in Belief Updating and Phasic Arousal Are Related to Psychosis Proneness

The paper links individual differences in belief updating and phasic arousal to psychosis proneness in a community sample.

A spectrum of altered non-rapid eye movement sleep in schizophrenia

This study replicates group-level sleep EEG differences in schizophrenia and shows increased patient-to-patient variability in NREM metrics, with medication and age-related effects contributing to this heterogeneity.

D1-like receptor activation rescues hippocampal synaptic plasticity and cognitive impairments in the MK-801 schizophrenia model.

This study shows that activating D1-like dopamine receptors improves synaptic plasticity and spatial memory in a schizophrenia model, suggesting a potential therapeutic approach.

The impact of Subclinical Psychotic Symptoms on Delay and Effort discounting: insights from behavioral, computational, and electrophysiological methods

This study examines how subclinical psychotic symptoms affect delay and effort discounting using behavioral, computational, and electrophysiological methods, finding greater delay discounting and altered dopamine-related effort willingness in high PS participants.

Overexpression of the schizophrenia risk gene C4 in PV cells drives sex-dependent behavioral deficits and circuit dysfunction.

This study shows that overexpressing the schizophrenia risk gene C4 in PV cells causes sex-dependent behavioral and circuit dysfunction in mice.

Repeated Sub-anaesthetic dose of Ketamine Elevates Superoxide Dismutase in Pharmacological Model of Schizophrenia-Like Phenotypes in Mice

The paper evaluates behavioural and antioxidant changes in mice after repeated sub-anaesthetic ketamine doses, finding increased locomotor activity and SOD levels.

Sex-dependent effects of Setd1a haploinsufficiency on development and adult behaviour

This study investigates the effects of Setd1a haploinsufficiency in mice, finding sex-dependent behavioral changes relevant to schizophrenia and suggesting limitations in antipsychotic efficacy.

The impact of sex on gene expression in the brain of schizophrenic patients: a systematic review and meta-analysis of transcriptomic studies

This paper identifies sex-based transcriptomic differences in schizophrenia patients across specific brain regions through meta-analysis of bulk RNA-sequencing studies.

GPT-3 reveals selective insensitivity to global vs. local linguistic context in speech produced by treatment-naive patients with positive thought disorder

This paper uses GPT-3 to quantify global vs. local context sensitivity in speech from schizophrenia patients and finds disorganized speech shows insensitivity to global context, predicting positive thought disorder.

Poor Self-Reported Sleep is Associated with Prolonged White Matter T2 Relaxation in Psychotic Disorders

The paper investigates the link between poor self-reported sleep and prolonged white matter T2 relaxation in patients with psychotic disorders, finding a significant correlation with water T2 relaxation times.

Genomic Insights into the Shared and Distinct Genetic Architecture of Cognitive Function and Schizophrenia

This study identifies shared and distinct genetic factors between cognitive traits and schizophrenia using genomic structural equation modelling and GWAS data.

Pharmacological enhancement of dopamine neurotransmission does not affect illusory pattern perception

This study investigates whether dopamine manipulation affects illusory pattern perception in healthy individuals, finding no significant effect of L-DOPA on false alarm rates or other measures.

Integrative Transcriptomics Reveals Layer 1 Astrocytes Altered in Schizophrenia

The paper identifies altered layer 1 astrocytes in schizophrenia using spatial and single-nucleus transcriptomics of the anterior cingulate cortex.

Decoding Early Psychoses: Unraveling Stable Microstructural Features Associated with Psychopathology Across Independent Cohorts

The paper identifies a stable microstructural white matter signature associated with negative and somatic symptoms in early psychosis across two independent cohorts using PLS correlation.

Transcriptomics and proteomics of projection neurons in a circuit linking hippocampus with dorsolateral prefrontal cortex in the human brain

The paper analyzes transcriptomic and proteomic data from specific brain regions to identify molecular changes in schizophrenia, showing superior regional discrimination in transcriptomic and proteomic data.

Multimodal fusion of brain signals for robust prediction of psychosis transition

The paper uses multimodal machine learning to predict psychosis conversion and finds that integrating multiple data types improves prediction accuracy.

Genetic implication of prenatal GABAergic and cholinergic neuron development in susceptibility to schizophrenia

The paper investigates genetic risk for schizophrenia by analyzing gene expression and regulatory elements in developing ganglionic eminence neurons.

Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission

This study compares neuronal phenotypes from monozygotic twins discordant for schizophrenia, finding differences in synaptic activity and neuronal maturation between affected and unaffected siblings.

A Functional Schizophrenia-associated genetic variant near the TSNARE1 and ADGRB1 genes.

The paper tests a schizophrenia-associated variant near TSNARE1 and ADGRB1 for functional effects, showing allele-specific transcriptional differences and pathway enrichment in synaptic processes.

Long-term adaptation of prefrontal circuits in a mouse model of NMDAR hypofunction

This study investigates the long-term effects of subchronic PCP treatment on prefrontal circuits in mice, revealing alterations in cognitive performance, gamma oscillations, and synaptic connectivity associated with schizophrenia endophenotypes.

Calneuron 1 reveals the pivotal roles in schizophrenia via perturbing human forebrain development and causing hallucination-like behavior in mice

The paper identifies CALN1 as a key schizophrenia gene by showing its role in disrupting forebrain development and causing hallucination-like behavior in mice.

Macro- and Micro-Structural Alterations in the Midbrain in Early Psychosis

This study identifies macro- and micro-structural midbrain alterations in early psychosis using multimodal MRI analyses and links them to clinical outcomes.

Genetic susceptibility to schizophrenia through neuroinflammatory pathways is associated with retinal thinning: Findings from the UK-Biobank

This study links genetic risk for schizophrenia with retinal thinning using UK Biobank data, highlighting neuroinflammatory pathways as a potential mechanism.

Cell-Type Specific Reductions in Interneuron Gene Expression within Subregions of the Anterior and Posterior Cingulate Gyrus of Schizophrenia and Bipolar Disorder Subjects

Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosis

This study links neurotransmitter pathway polygenic risk to specific symptom profiles in psychosis, identifying associations between glutamate and dopamine pathways with cognitive control and global functioning.

Transcriptional and neurochemical signatures of cerebral blood flow alterations in schizophrenia and the clinical high-risk state for psychosis

The paper identifies cellular and neurochemical signatures associated with cerebral blood flow alterations in schizophrenia and clinical high-risk states using combined neuroimaging and transcriptomic data.