Circadian rhythm and melatonin

Fibroblasts as an in vitro model of circadian genetic and genomic studies

This study examines circadian genetic architecture in fibroblasts to assess its contribution to bipolar disorder risk, finding limited gene expression patterns and no significant genetic associations with BD.

Sleep Deprivation, Sleep Fragmentation and Social Jet Lag increase temperature preference in Drosophila

This study shows that sleep deprivation, fragmentation, and social jet lag in Drosophila increase temperature preference, suggesting a link between sleep disruption and thermoregulation through specific clock neurons.

Are circadian amplitudes and periods correlated? A new twist in the story

The paper defines and analyzes two types of amplitude-period correlations in circadian rhythms and shows their impact on oscillator-environment interactions.

Astrocytic control of extra-cellular GABA drives circadian time-keeping in the suprachiasmatic nucleus

The paper shows that astrocytic GABA transporters regulate extracellular GABA levels in the SCN, which in turn controls circadian time-keeping through neuronal inhibition.

Evidence for conservation of primordial 12-hour ultradian gene program in humans under free-living conditions.

The paper identifies robust ~12h transcriptional rhythms in human peripheral white blood cells under free-living conditions, showing homology to circatidal gene programs in marine species.

Dynamic modulation of genomic enhancer elements in the suprachiasmatic nucleus mediates daily timekeeping in mammals

The paper identifies SCN enhancers with 24-hour rhythmic H3K27ac modulation and links them to gene expression cycles through RNA-Seq and eRNA analysis.

Cryptochrome-Timeless structure reveals circadian clock timing mechanisms

The paper presents the cryo-EM structure of the CRY:TIM complex, revealing molecular mechanisms of circadian clock timing and light entrainment.

Kronos: A computational tool to facilitate biological rhythmicity analysis

Kronos is an R-based tool for analyzing circadian rhythms in biological datasets, supporting complex study designs and high-dimensional omics data.

The nutrient-sensing GCN2 signaling pathway is essential for circadian clock function by regulating histone acetylation under amino acid starvation

Immediate effects of light on circadian eclosion and locomotor activity depend on distinct sensory input pathways

The paper shows that light affects eclosion and locomotor activity in Drosophila through distinct sensory pathways.

A mouse model for environmentally induced and reversible circadian arrhythmia using gradual exposure to a fragmented day-night cycle

This study shows that gradual exposure to a fragmented day-night cycle induces reversible circadian arrhythmia in mice.

Regulation of the circadian clock in C. elegans by clock gene homologs kin-20 and lin-42

This study investigates the role of lin-42 and kin-20 in the circadian clock of C. elegans using a bioluminescence reporter, showing they regulate the period length through neuronal cells.

Circadian rhythm disruptions associated with opioid use disorder in the synaptic proteomes of the human dorsolateral prefrontal cortex and nucleus accumbens

The paper identifies synaptic protein alterations and circadian rhythm disruptions in brain regions associated with opioid use disorder using proteomics.

Circadian regulation of hippocampal function is disrupted with chronic corticosteroid treatment

This study shows chronic corticosteroid exposure disrupts circadian regulation of hippocampal function and synaptic plasticity in rats, leading to memory loss.

Time-of-day-dependent variation of the hepatic transcriptome and metabolome is disrupted in non-alcoholic fatty liver disease patients

The paper examines time-of-day-dependent transcriptome and metabolome variations in human NAFL and NASH livers, finding disruptions in rhythmic gene expression and metabolites.

Spatially coordinated collective phosphorylation filters spatiotemporal noises for precise circadian timekeeping

The paper develops a mathematical model showing how spatially coordinated phosphorylation of PER protein ensures precise and robust circadian rhythms despite spatiotemporal noise.

Plasticity manifolds and ion-channel degeneracy govern circadian oscillations of neuronal intrinsic properties in the suprachiasmatic nucleus

The paper investigates how SCN neurons maintain circadian oscillations despite ion channel variability, revealing ion-channel degeneracy and a plasticity manifold that enable stable transitions.

The Role of Terminal Uridyl Transferases in the Circadian Rhythm

This study shows that terminal uridylation of mRNA is rhythmic in mouse liver and that knocking down TUT4 and TUT7 disrupts circadian rhythms.

An extra-circadian function for human CLOCK in the neocortex

This study shows that human CLOCK has extra-circadian functions in the neocortex, enhancing cognitive flexibility and neural connectivity through altered gene expression in excitatory neurons.

Antisense transcription of the Neurospora frequency gene is rhythmically regulated by CSP-1 repressor but dispensable for clock function

The paper shows that antisense RNA qrf transcription is not required for circadian clock function in Neurospora crassa, but its evening rhythm is controlled by the morning repressor CSP-1.

A leptin-responsive hypothalamic circuit inputs to the circadian feeding network

The paper identifies a leptin-responsive hypothalamic circuit that influences circadian feeding rhythms by modulating SCN activity and food entrainment.

Circadian clock genes Bmal1 and Per2 in the nucleus accumbens are negative regulators of alcohol-drinking behavior in mice.

This study shows that Bmal1 and Per2 in the nucleus accumbens reduce alcohol consumption in male mice, but not in females, with Bmal1's effect being specific to the nucleus accumbens in females.

CLOCK and TIMELESS regulate rhythmic occupancy of the BRAHMA chromatin-remodeling protein at clock gene promoters

This study shows CLOCK and TIMELESS regulate daily rhythmic BRM chromatin-remodeling activity at clock gene promoters in Drosophila.

Coupling allows robust redox circadian rhythms despite heterogeneity and noise

This study shows coupling enables robust circadian rhythms in redox oscillators despite noise and heterogeneity.

Day-night and seasonal variation of human gene expression across tissues

The paper investigates day-night and seasonal gene expression variation across human tissues using GTEx data, finding unique patterns in different tissues and conserved clock gene differences across species.

Sex-dimorphic and age-dependent organization of 24 hour gene expression rhythms in human

Circadian phase inference of 914 GTEx donors reveals sex- and age-dependent rhythmic gene expression programs across 46 human tissues.

Circadian Gene Expression in Mouse Renal Proximal Tubule

The paper identifies circadian gene expression patterns in mouse renal proximal tubules and provides a web resource for these data.

Circadian regulation of dentate gyrus excitability mediated by G-protein signaling

This study shows that mouse dentate granule neurons exhibit a 24-hour excitability oscillation regulated by G-protein signaling and Bmal1, affecting memory and spatial discrimination.

Arginine-Vasopressin Expressing Neurons in the Murine Suprachiasmatic Nucleus Exhibit a Circadian Rhythm in Network Coherence In Vivo

This paper uses in vivo calcium imaging and electrophysiology to show AVP neurons in the SCN exhibit unstable single-cell rhythms but coherent network activity with a strong circadian rhythm.

Time distributed data analysis by Cosinor.Online application

Browser-based cosinor fitting for circadian and ultradian rhythms with no install; 24-hour results matched two existing programs, ultradian results diverged slightly from one of them.