Hematopoietic Stem Cell Transplantation

Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells

The paper defines the transcriptomes and epigenomes of key developmental stages of HSC ontogeny in mice and constructs transcriptional regulatory networks using computational methods.

Mechanical instabilities of aorta drive blood stem cell production: a live study

The paper shows that mechanical instabilities in the aorta drive the extrusion of haematopoietic stem/progenitor cells during embryogenesis through collective endothelial cell migration.

Trophoblast paracrine signaling regulates placental hematoendothelial niche

This study shows that GATA2 and GATA3 in trophoblast giant cells regulate hematopoietic-angiogenic balance in the placenta through paracrine signaling.

Single-cell atlas of major haematopoietic tissues sheds light on blood cell formation from embryonic endothelium

The paper compares single-cell RNA sequencing data from Yolk Sac and AGM in mouse embryos to identify differences in hematopoietic potential and cell populations.

Single-cell tracing of the first hematopoietic stem cell generation in human embryos

The paper uses single-cell RNA sequencing to trace the emergence of hematopoietic stem cells in human embryos, identifying key gene expression patterns and cell populations involved in their development.

Glucocorticoids Induce the Expansion of an Immature Human CFU-E Population

This study shows glucocorticoids expand immature CFU-E cells in peripheral blood but not cord blood, with p57Kip2 playing a key role in this effect.

Control of Hematopoietic Stem Cell Function Through Epigenetic Regulation of Energy Metabolism and Genome Integrity

This study shows that DPY30, an epigenetic modulator, controls hematopoietic stem cell function by regulating energy metabolism and genome integrity through H3K4 methylation.

Checkpoint kinase 1 is essential for fetal haematopoiesis and hematopoietic stem cell survival

This study shows that CHK1 is essential for hematopoietic stem cell survival and fetal hematopoiesis, and that its inhibition causes severe DNA damage and prevents HSC expansion.

Decoding the development of the blood and immune systems during human fetal liver haematopoiesis

The paper uses single-cell transcriptomics to map hematopoiesis in human fetal liver, identifying cell differentiation trajectories and shifts in hematopoietic composition during development.

Dose-dependent role of Gfi1 in murine hematopoietic stem cell self-renewal and differentiation

This study investigates the dose-dependent role of Gfi1 in murine hematopoietic stem cell self-renewal and differentiation, finding that reduced Gfi1 levels impair myeloid and lymphoid differentiation.

LncRNA Spehd regulates hematopoietic stem cells and progenitors and is required for multilineage differentiation

The paper identifies lncRNA Spehd as essential for hematopoietic stem cell differentiation and multilineage potential in mice.

Hematopoietic Stem Cell Dynamics are Regulated by Progenitor Demand: Lessons from a Quantitative Modeling Approach

This study develops an in-silico model to explore how hematopoietic stem cells (HSCs) respond to varying demands and aging, showing that internal feedback between HSCs and progenitors explains homeostasis and aging-related changes.

GRIMM: GRaph IMputation and Matching for HLA Genotypes

GRIMM improves HLA genotype matching efficiency using a graph database, achieving faster runtime and agreement with consensus outputs on a validation dataset.

Clonal Level Lineage Commitment Pathways of Hematopoietic Stem Cells In Vivo

This study maps clonal lineage commitment pathways of hematopoietic stem cells in vivo, revealing differences in clonal behavior under homeostasis and after hematopoietic depletion.

HSCs contribute actively to native multilineage hematopoiesis but with reduced differentiation capacity upon aging

This study shows that adult HSCs contribute to all blood lineages in steady state but decline in contribution with age due to reduced differentiation capacity.

Modeling large fluctuations of thousands of clones during hematopoiesis: the role of stem cell self-renewal and bursty progenitor dynamics in rhesus macaque

The paper models clone fluctuations in rhesus macaque hematopoiesis, showing that stochastic HSC self-renewal and progenitor proliferation constraints explain large temporal variations in clone abundance.

Machine Learning Approach to Predicting Stem-Cell Donor Availability

This study uses machine learning to predict individual donor availability for stem-cell transplants, improving selection efficiency.

Functional Compensation Between Hematopoietic Stem Cells In Vivo

The paper shows hematopoietic stem cells in mice compensate for functional deficiencies by increasing clonal expansion during lymphopoiesis, maintaining blood supply and influencing blood cell types.

Hierarchical organization of developing HSPC in the human embryonic liver

The paper identifies a hematopoietic hierarchy in the human embryonic liver and characterizes a multipotent population with self-renewal and differentiation potential.

Emergence of the erythroid lineage from multipotent hematopoiesis

The paper uses single-cell transcriptomics and fate potential assays to map the erythroid differentiation trajectory from multipotent hematopoietic stem cells in mice, revealing novel regulators and transcriptional programs.

Unrelated Donor Selection for Stem Cell Transplants using Predictive Modelling

This study uses machine learning to improve unrelated donor selection for stem cell transplants by analyzing historical selection data.

Single Cell Phenotyping Reveals Heterogeneity among Haematopoietic Stem Cells Following Infection

The paper uses single-cell tracking to show that HSCs from infected mice exhibit heterogeneous movement patterns compared to controls, with increased persistence possibly aiding survival in altered niche environments.

CBFβ initiates the hematopoietic stem cell program without obligatory binding to RUNX

The paper shows that CBFβ can regulate gene expression independently of Runx, challenging the dogma that CBFβ's gene regulatory functions require Runx binding.

Discovery of a new path for red blood cell generation in the mouse embryo

The paper identifies a new pathway for red blood cell generation in the mouse embryo by discovering hemogenic endothelial cells that can produce erythrocytes independently of Runx1.