Regulation of Appetite and Obesity

Acute threats modulate hunger circuit dynamics to instruct avoidance behaviour

This study shows that hunger-sensitive AgRP neurons in the hypothalamus are inhibited by threats, leading to avoidance behavior through GABAergic inputs from DMH neurons.

Cellular coding of ingestion in the caudal brainstem

The paper investigates how food ingestion is encoded in the caudal nucleus of the solitary tract (cNTS) by comparing neural activity during gastric and oral food delivery in behaving animals.

A Preoptic Neurocircuit That Modulates Metabolic Flexibility

The paper identifies a preoptic neurocircuit that modulates metabolic flexibility by shifting fuel use from glucose to fatty acids through insulin resistance in skeletal muscle.

A dorsal hippocampus-prodynorphinergic dorsolateral septum-to-lateral hypothalamus circuit mediates contextual gating of feeding

The paper identifies a circuit involving DLS Pdyn neurons that links contextual cues to feeding regulation through inhibition of LHA GABAergic neurons.

Sex-specific control of feeding and defensive behaviors by MC3R neurons in the bed nuclei of the stria terminalis

This study shows that MC3R neurons in the BST modulate feeding and defensive behaviors, with sex-specific effects on feeding reduction and stress responses.

Ectopic, hepatic GLP-1R agonism enhances the weight loss efficacy of GLP-1 analogues.

The paper shows that combining GLP-1R agonists with ectopic hepatic GLP-1R expression enhances weight loss in mice by increasing energy expenditure and reducing food intake.

Ghrelin and Mboat4 are lost in Serpentes

The paper identifies the independent loss of ghrelin and Mboat4 in snakes, chameleons, and toadhead agamas, linking it to adaptations in energy metabolism.

Olfactory inputs to appetite neurons in the hypothalamus

This study identifies distinct olfactory pathways to appetite-regulating neurons in the hypothalamus, showing differential input to AgRP and POMC neurons.

Elevated activity of the mesolimbic dopamine system promotes feeding during pregnancy in mice

This study identifies increased mesolimbic dopamine system activity as a driver of hedonic feeding and sensitivity to energy imbalance during pregnancy in mice.

Effects of chronic intraperitoneal administration of the GABA-B receptor agonist 3-aminopropyl (methyl) phosphinic acid on food intake and body weight in rats

This study shows that chronic SKF-97541 administration reduces body weight gain in rats without affecting food intake, supporting the role of GABAB receptors in weight regulation through increased metabolic rate.

THIK-1 channel mediates microglial glucose sensing and modulates AgRP neurons

This study identifies THIK-1 channel as a glucose sensor in microglia that modulates AgRP neuron activity and feeding behavior in diet-induced obesity.

Hypothalamic CYP46A1 cholesterol metabolism regulates diet-induced obesity

This study identifies Cyp46a1 as a critical regulator of diet-induced obesity by modulating body weight, adipocyte size, and metabolic parameters through hypothalamic cholesterol metabolism.

Effects of the GABAB receptor agonist 3-aminopropyl (methyl) phosphinic acid on food intake in free feeding rats

This study investigates the effects of SKF97541, a GABAB receptor agonist, on food intake in rats, finding dose-dependent increases and tolerance effects.

INTEROCEPTIVE INFORMATION OF PHYSICAL VIGOR THROUGH CIRCULATING INSULIN-LIKE GROWTH FACTOR 1

This study shows that circulating IGF-1 signals physical vigor to the brain via orexin and VTA neurons, modulating physical activity and exercise reward.

Tirzepatide Synergizes with Leptin on Weight Loss and Restoring Metabolic Homeostasis in Diet-induced Obesity Model

This study shows tirzepatide and leptin together enhance weight loss and metabolic homeostasis in diet-induced obesity by improving insulin sensitivity and neuronal signaling.

Susceptibility of Glucose Regulation to Social Isolation

This study shows that social isolation causes fasting hyperglycemia in male mice, which is mediated by testicular hormones and glucoregulatory brain neurons, but not in females.

The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signaling

This study shows MRAP2 interacts with MC3R to enhance its signaling, affecting energy homeostasis and obesity risk.

Insular cortex predictions regulate glucose homeostasis

The paper shows that insular cortex activity predicts glucose homeostasis by driving anticipatory insulin release and metabolic regulation.

From stomach to striatum: Ghrelin infusions increase work for rewards

This paper investigates the effects of ghrelin infusions on motivation and brain activity in humans, finding increased effort for rewards and enhanced striatal connectivity.

Cocaine- and amphetamine-regulated transcript in perciforms II. Responsiveness to energetic shortage

This study examines how food deprivation affects cart gene expression in Nile tilapia and gilthead seabream, revealing species-specific responses in brain regions.

Dual Activation of MC3R and MC4R Drives Weight Loss and Reduces Food Intake in Obese Primates

This study shows that activating both MC3R and MC4R in obese primates leads to weight loss and reduced food intake, with a new dual agonist peptide showing efficacy and safety.

Aging reveals divergent responses of AgRP/NPY neurons to diet in male and female mice.

This study investigates how diet and age affect AgRP/NPY neuronal activity in female mice, finding sex and age-dependent responses to high-fat diets.

Tanycyte-mediated synapse pruning shapes hypothalamic circuits controlling metabolism.

This study identifies tanycytes as glial cells that prune synapses in the hypothalamus, affecting metabolism and body weight control.

Lateral hypothalamus CRFR1 regulation of chronic binge drinking: divergence along anterior-posterior axis

This study investigates the role of CRFR1 in the lateral hypothalamus during chronic binge drinking, finding that posterior LH CRFR1 knockdown increases alcohol consumption while also increasing anxiety and reducing sucrose preference.

A line attractor maintains aggressiveness during feeding in hangry mice

The paper shows that a line attractor in the hypothalamus modulates aggression in mice during feeding, with hunger enhancing aggressiveness but prolonged starvation reducing it.

Obesity dysregulates feeding-evoked response dynamics in hypothalamic satiety neurons

This study shows that obesity alters the response dynamics of hypothalamic satiety neurons to food consumption, with high-fat diet-fed animals showing exaggerated early responses and reduced response progression during meals.

Tanycytic annexinA1-containing extracellular vesicles control thermogenesis by orchestrating microglial and neuronal functions.

The paper identifies Annexin A1-containing extracellular vesicles from tanycytes that regulate thermogenesis and energy balance by modulating microglial and neuronal functions in obesity.

Within-subject daily rhythmicity and longitudinal stability of hunger, satiety, and physiological markers

This study examines daily rhythmicity and stability of hunger, satiety, and physiological markers over five days in healthy males, finding individual variability and correlations with heart rate and glucose levels.

Single-nucleus transcriptional and chromatin accessibility profiling of mouse hypothalamic LepRb neurons reveals cell type-specific cis-regulatory elements linked to human obesity

Hunger modulates exploration through suppression of dopamine signaling in the tail of striatum

The paper shows that hunger increases exploration by modulating dopamine signaling in the tail of the striatum via AgRP neurons.