Regulation of Appetite and Obesity

Pharmacological Modulation of MC4R in the Periaqueductal Gray Does Not Alter Social Behavior

This study investigates the role of MC4R in the periaqueductal gray (PAG) on social behavior in male rats using pharmacological manipulation, finding no significant effect on social interaction time.

Comparative transcriptomics of lateral hypothalamic cell types reveals conserved growth hormone-tachykinin dynamics in feeding

The paper identifies conserved GABAergic neurons in zebrafish and mouse lateral hypothalamus that respond to growth hormone and food cues, revealing a shared mechanism for appetite regulation.

BDNF receptor balance gates AgRP-to-PVH fiber density and stimulation evoked feeding across caloric states

The paper shows that the balance of BDNF receptors TrkB and p75NTR in AgRP neurons controls PVH fiber density and stimulation-evoked feeding across different caloric states.

Satiation is associated with OGT-dependent regulation of excitatory synapses.

This study shows that OGT regulates excitatory synaptic plasticity in PVN CaMKII neurons, linking metabolic state to satiation signaling through changes in synaptic input resistance and activity during feeding and hunger.

Glial plasticity and metabolic stability after knockdown of astrocytic Cx43 in the dorsal vagal complex

This study investigates the effect of astrocytic Cx43 knockdown in the dorsal vagal complex on metabolic phenotype and glial plasticity in mice, finding no significant metabolic changes despite altered glial morphology.

Sex-Specific Metabolic and Central Effects of GLP-1 Estradiol Conjugate in Middle-Aged Rats on a Standard or Western Diet

This study examines the sex-specific metabolic and cognitive effects of GLP-1 estradiol conjugate in middle-aged rats on standard or Western diets, showing differential impacts on weight, cytokines, and neurogenesis.

Reduced melanocortin tone mediates increased feeding during pregnancy in mice

This study identifies that increased AgRP neuron activity and decreased POMC neuron activity during pregnancy in mice drive hyperphagia, with spatial transcriptomics revealing transcriptional changes in these neurons.

Binge Feeding Promotes Appetite via Modulating Olfactory Flavor Representation

This study shows binge feeding increases food intake by suppressing olfactory flavor representation in the anterior piriform cortex through specific neuronal activity patterns.

Neurosecretory protein GL stimulates feeding behavior and fat accumulation in Japanese quails (Coturnix japonica)

This study shows that NPGL increases body mass, food intake, and fat accumulation in Japanese quails without affecting other metabolic parameters.

Development of a genetically encoded melanocortin sensor for high sensitivity intravital imaging

This paper develops a genetically encoded melanocortin sensor, FLAREMC, for high sensitivity intravital imaging of melanocortin signaling in vivo.

Neural Circuit Remodeling Underlying Enhanced Feeding During Pregnancy in Mice

The paper shows pregnancy in mice reduces excitatory inputs to PVH oxytocin neurons, promoting increased food intake by dampening their anorexigenic activity.

AgRP Neuronal Suppression by Spontaneous Movement Encodes Exercise Reinforcement

The paper shows that spontaneous movement suppresses AgRP neuron activity, reinforcing exercise behavior in mice.

Adaptive thermogenesis reprograms the behavioural and metabolic responses to protein restriction for successful amino acid homeostasis

This study shows that mice adjust their behavior and metabolism in response to protein restriction, with temperature affecting amino acid homeostasis and metabolic adaptations.

Polyunsaturated fatty acids promote appetite via the microbiome-gut-brain axis

The paper shows that polyunsaturated fatty acids increase appetite by enhancing brain serotonin levels through the gut microbiome.

Chronic semaglutide treatment reveals stage-dependent changes to feeding behavior and metabolic adaptations in male mice

This study examines how chronic semaglutide treatment affects feeding behavior and metabolic adaptations in obese male mice, identifying stage-specific changes in weight loss and regain.

Oxytocin neurons in the paraventricular and supraoptic hypothalamic nuclei bidirectionally modulate food intake

This study shows that oxytocin neurons in the paraventricular and supraoptic hypothalamic nuclei have opposing effects on food intake, with PVH neurons reducing meal size and SON neurons increasing it.

Control of Physiologic Glucose Homeostasis via the Hypothalamic Modulation of Gluconeogenic Substrate Availability

The paper identifies VMNCckbr neurons that regulate fasting blood glucose by enhancing adipose tissue lipolysis and substrate release via the sympathetic nervous system.

A PHOX2b+ PONTINE NUCLEUS ESSENTIAL FOR INGESTION.

The paper identifies a hindbrain neuron cluster, Sup5Phox2b, essential for coordinating biting and chewing during feeding.

Diet context gates AgRP neuron involvement in Semaglutide-induced weight loss

The paper shows that AgRP neurons are necessary for Semaglutide-induced weight loss in female mice on standard diet but not on high-fat diet.

Medial preoptic area FoxO1 controls metabolic adaptation in a sexually dimorphic manner

This study shows FoxO1 in the medial preoptic area (MPOA) influences metabolic adaptation to diet and temperature, with effects specific to female mice.

Melanocortin-responsive Kiss1 neurons of the arcuate nucleus drive energy expenditure through glutamatergic signaling to the dorsomedial hypothalamus.

The paper identifies arcuate nucleus Kiss1 neurons as regulators of energy expenditure through glutamatergic signaling to the dorsomedial hypothalamus in male mice.

A simple action reduces high fat diet intake and obesity in mice

This study shows that requiring mice to perform a simple action to access high-fat diet reduces intake and prevents obesity, suggesting that easy access promotes overeating.

Microglia are Required for Developmental Specification of AgRP Innervation in the Hypothalamus of Offspring Exposed to Maternal High Fat Diet During Lactation

The paper shows that microglia are necessary for proper AgRP neuron innervation to the PVH in offspring exposed to maternal high-fat diets during lactation, affecting metabolic outcomes.

Distinct Neural Representations of Hunger and Thirst in Neonatal Mice before the Emergence of Food- and Water-seeking Behaviors

This study shows that neural representations of hunger and thirst are distinct in neonatal mice before they can seek food and water separately, and these representations persist despite environmental changes.

The metabolic and molecular mechanisms underlying running-induced energy compensation

This study identifies how running-induced energy compensation occurs through metabolic and molecular mechanisms involving leptin, hypothalamic neurons, and Neuropeptide Y in young mice.

An amygdalopontine pathway promotes motor programs of ingestion

This study identifies an amygdalopontine pathway that drives ingestive behaviors independent of satiety signals, promoting goal-directed motor programs of ingestion.

Role of CCK1 receptor in metabolic benefits of intestinal enteropeptidase inhibition in mice

This study investigates how CCK1 receptor signaling mediates the metabolic effects of enteropeptidase inhibition in mice, finding both CCK1R-dependent and -independent mechanisms contribute to weight loss.

Anorectic and anxiogenic actions of cocaine- and amphetamine-regulated transcript in the lateral septum

This study investigates the effects of CART in the lateral septum, finding it suppresses palatable food intake and increases anxiety-like behavior, potentially opposing MCH's effects.

A mutation in the transmembrane domain of Adenylate cyclase 3 impairs enzymatic function to cause sex-specific depression- and anxiety-like behaviors and food seeking in a rat model

This study shows that a mutation in the transmembrane domain of Adcy3 in rats leads to sex-specific changes in adiposity, behavior, and cAMP production.

Alk-Fam150b (augmentor α) expression in the paraventricular nucleus of the mouse hypothalamus at molecular resolution, and its sensitivity to acute stress

The paper demonstrates Fam150b and Alk expression in the PVN of adult mice, shows their exclusive expression in CRH neurons, and finds stress-induced upregulation of Fam150b mRNA.