Retinal Development and Disorders

Retinal ganglion cells undergo cell type-specific functional changes in a biophysically detailed model of retinal degeneration

The paper presents a biophysically detailed model of retinal degeneration that simulates network-level responses to light and electrical stimulation, showing how degeneration affects RGC activity.

Not all Notch pathway mutations are equal in the embryonic mouse retina

The paper investigates Notch pathway mutations in the embryonic mouse retina, finding that Notch signaling is not required for Hes1 sustained expression in the optic stalk/nerve head but has opposing roles in photoreceptor genesis.

Functional integrity of visual coding following advanced photoreceptor degeneration

The paper shows that surviving retinal circuits can generate a functional visual code similar to wildtype even after advanced photoreceptor degeneration using optogenetic stimulation.

Ythdf2 ablation protects aged retina from RGC dendrite shrinking and visual decline

This study shows that removing Ythdf2 in aged mice prevents RGC dendrite shrinkage and vision loss by targeting Hspa12a and Islr2.

Ikaros family proteins regulate developmental windows in the mouse retina through convergent and divergent transcriptional programs

This study shows Ikzf1 and Ikzf4 regulate distinct cell fates in the mouse retina through different cis-regulatory elements and temporal expression patterns.

Foxd1 dependent induction of temporal retinal character is required for visual function

This study shows that Foxd1 is required for temporal retinal character, which is essential for the development of the high acuity area and visual function in zebrafish.

Transcriptional mapping of the macaque retina and RPE-choroid reveals conserved inter-tissue transcription drivers and signaling pathways

The paper maps transcriptional profiles in macaque retina and RPE-choroid tissues, identifying conserved gene expression patterns and signaling pathways relevant to high-acuity vision and disease.

Use of vivo-morpholinos for gene knockdown in the postnatal shark retina

This study develops a method for gene knockdown in the postnatal shark retina using Vivo-Morpholinos, demonstrating reduced PCNA expression and mitotic activity in the peripheral retina.

Characterization of retinal development in 13-lined ground squirrels

This study characterizes retinal development in 13-lined ground squirrels, showing a timeline similar to other mammals but with a higher proportion of cone-dense photoreceptors.

Expression of NMNAT1 in the Photoreceptors is Sufficient to Prevent NMNAT1-Associated Disease

This study shows that expressing NMNAT1 specifically in photoreceptors prevents retinal degeneration in a mouse model of NMNAT1-associated disease.

Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas

This study shows CNTF treatment in degenerating mouse retinas enhances glycolysis and anabolism, improving neuronal viability through metabolic changes.

Loss of GFAP causes retinal dysplasia and vision impairment

The paper identifies a loss-of-function GFAP variant causing retinal dysplasia and vision impairment in a family, revealing a novel role for GFAP in eye development.

CyclinD2-mediated regulation of neurogenic output from the retinal ciliary margin is perturbed in albinism

The paper investigates how CyclinD2 regulates RGC neurogenesis in the mouse ciliary margin zone and shows its disruption in albinism leads to impaired binocular vision.

Awakening adult neural stem cells: NOX signalling as a positive regulator of quiescence to proliferation transition in the Xenopus retina

The paper investigates ROS signaling in Xenopus retinal stem cells, showing NOX promotes quiescence-to-proliferation transition by modulating Wnt/Hedgehog signaling.

The developmental progression of eight opsin spectral signals recorded from the zebrafish retinal cone layer is altered by the timing and cell type expression of thyroxin receptor β2 (trβ2) gain-of-function transgenes.

The paper analyzes how trβ2 transgenes alter opsin signaling in zebrafish retinas across development, showing different amplitude changes in larvae, juveniles, and adults.

Developing and adult reef fish show rapid, reversible light-induced plasticity in their visual system

This study shows that reef fish can rapidly and reversibly adjust their retinal opsin expression and cell densities in response to short-term changes in light conditions.

Using single molecule Molecular Inversion Probes as a cost-effective, high-throughput sequencing approach to target all genes and loci associated with macular diseases.

The paper uses smMIPs to sequence MD-associated genes and loci in patients, achieving high coverage and a 38% diagnostic yield.

Single-cell transcriptomic profiling in inherited retinal degen-eration reveals distinct metabolic pathways in rod and cone photoreceptors

This study uses scRNA-seq to analyze metabolic changes in mouse retinal cells during degeneration, identifying Ca2+-signaling and MAPK pathway involvement.

Transcriptomic remodeling of the retina in a Zebrafish model of Retinitis Pigmentosa

This study analyzes single-cell transcriptomes of wild-type and P23H mutant zebrafish retinas to identify transcriptional changes during retinal degeneration.

Timed Notch Inhibition drives Photoreceptor fate specification in Human Retinal Organoids

The paper inhibits Notch signaling at different stages of retinal organoid differentiation to enhance photoreceptor specification, showing increased cone and rod markers at specific timepoints.

Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina.

This study shows that GFAP promoter-driven AAV constructs in adult mouse retina show insert-dependent expression in non-glial cells without evidence of glia-to-neuron conversion.

Single-cell RNA sequencing reveals molecular features of postnatal maturation in the murine retinal pigment epithelium

The paper uses single-cell RNA sequencing to analyze RPE cell heterogeneity in mice, identifying six cell populations and changes in gene expression during maturation.

PRPF31 interacts with PRPH2 confirmed by co-immunoprecipitation and co-localization

The paper confirms that PRPF31 interacts with PRPH2 through co-immunoprecipitation and co-localization experiments in human and mouse cells.

Knockout of Bbs10 results in lack of cone electrical function and progressive retinal degeneration of rods and cones

This study develops a BBS10 knockout mouse model to investigate retinal degeneration, finding progressive loss of cone function and thinning of the outer nuclear layer.

Robust cone-mediated signaling persists late into rod photoreceptor degeneration

This study shows that cone-mediated signaling remains robust in retinal ganglion cells despite rod photoreceptor degeneration, suggesting gene therapies may still effectively preserve vision.

Special Nuclear Layer Contacts Among Starburst Amacrine Cells in the Mouse Retina

The paper identifies novel nuclear layer contacts between starburst amacrine cells in the mouse retina through detailed morphological analysis of electron microscopic data.

Expression and subcellular localization of USH1C/harmonin in the human retina provide insights into pathomechanisms and therapy

The paper investigates harmonin expression and localization in human retinas to understand USH1C pathophysiology and potential gene therapy approaches.

Patterns of NFkB activation resulting from damage, reactive microglia, cytokines, and growth factors in the mouse retina

The paper investigates how different cytokines, growth factors, and damage paradigms affect NFkB signaling in mouse retinal Muller glia, showing activation varies with microglial involvement.

Antisense oligonucleotide therapy for the common Stargardt disease type 1-causing variant in ABCA4

This study demonstrates that antisense oligonucleotides can correct splicing defects in the ABCA4 c.5461-10T>C variant, restoring protein function in retinal organoids.

Human photoreceptor cell transplants integrate into human retina organoids

This study shows that human photoreceptor cells transplanted into human retina organoids integrate structurally, forming clusters with cone and rod photoreceptors and host cell contacts.