Retinal Development and Disorders

LRIT3 expression in cone photoreceptors restores post-synaptic bipolar cell signalplex assembly and function in Lrit3-/- mice.

This study shows that LRIT3 expression in cone photoreceptors rescues signalplex assembly and function in Lrit3-/- mice, restoring visual function through trans-synaptic effects.

Development of dim-light vision in the nocturnal coral reef fish family, Holocentridae

The paper investigates visual system development in Holocentridae fish, showing ontogenetic shifts from photopic to scotopic vision with subfamily-specific adaptations.

Novel transient cell clusters provide a possible link between early neural activity and angiogenesis in the neonatal mouse retina

The paper identifies transient cell clusters in the neonatal mouse retina that link early neural activity to angiogenesis through purinergic signaling and microglial interaction.

Increased H3K27 trimethylation contributes to cone survival in a mouse model of cone dystrophy

This study investigates the effects of a histone demethylase inhibitor on cone cell survival in a mouse model of cone dystrophy, finding epigenetic modulation improves cone survival.

Retinoschisin deficiency induces persistent aberrant waves of activity affecting neuroglial signaling in the retina

This study investigates RS1 deficiency in mice, identifying aberrant neuro-glial activity and signaling disruptions that may inform therapeutic strategies for XLRS.

Vision-dependent and -independent molecular maturation of mouse retinal ganglion cells

This study uses scRNA-seq to analyze molecular maturation of mouse retinal ganglion cells, showing visual activity is not required for type identity but is needed for full maturation.

Nonviral base editing of KCNJ13 mutation preserves vision in an inherited retinal channelopathy

This paper demonstrates nonviral base editing of a KCNJ13 mutation in a mouse model of retinal degeneration, preserving vision through functional rescue of Kir7.1 channels.

The Dct-/- mouse model to unravel retinogenesis misregulation in patients with albinism

This paper investigates the retinal phenotype of Dct-/- mice to understand retinogenesis misregulation in albinism patients.

Comprehensive Characterisation of Fetal and Mature Retinal Cell Identity to Assess the Fidelity of Retinal Organoids

This study benchmarks retinal organoid protocols by comparing their cellular and molecular fidelity to fetal and adult human retinal tissues.

Identification of Arhgef12 and Prkci as Genetic Modifiers of Retinal Dysplasia in the Crb1rd8 Mouse Model

This study identifies Arhgef12 and Prkci as genetic modifiers that influence the severity of retinal dysplasia in the Crb1rd8 mouse model, revealing differential disease progression and cellular mislocalization.

Notch inhibition promotes regeneration and immunosuppression supports cone survival in a zebrafish model of inherited retinal dystrophy

Chromatin remodeler Chd7 regulates photoreceptor development and outer segment length

This study investigates the role of Chd7 in retinal development and photoreceptor outer segment formation in zebrafish and mouse, finding that its loss leads to reduced cone photoreceptors and truncated outer segments.

Transretinal migration of astrocytes and brain/spinal cord-like cells arising from transplanted human retinal organoids.

This study transplants human retinal organoids into mice and identifies two classes of graft-derived cells with distinct migration and maturation behaviors.

Inverse Problem Reveals Conditions for Characteristic Retinal Degeneration Patterns in Retinitis Pigmentosa under the Trophic Factor Hypothesis

The paper formulates a mathematical model of retinitis pigmentosa to derive experimentally testable conditions for the trophic factor hypothesis to replicate observed retinal degeneration patterns.

Human photoreceptors switch from autonomous axon extension to cell-mediated process pulling during synaptic marker redistribution.

This study investigates how human photoreceptor axons extend during development and regeneration, finding that they transition from autonomous growth to process pulling mediated by non-PR cells.

Regenerating axolotl retinas regrow diverse cell types with modulation by Notch signaling and reconnect to the brain

This study shows adult axolotls can regenerate retinas with diverse cell types and identifies Notch signaling's role in modulating regeneration.

Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa

This study shows that proinsulin activation of the insulin receptor preserves synapses and vision in retinitis pigmentosa by restoring signaling and synaptic connectivity.

Cone-driven retinal responses are shaped by rod but not cone HCN1

The paper investigates the role of HCN1 channels in retinal signaling, finding that rod-driven responses are affected by HCN1 knockout, while cone-driven responses remain unchanged.

NFkB-signaling suppresses Müller glia-mediated neuron regeneration in the mammalian retina

This study shows that NFkB signaling suppresses Müller glia-mediated neuron regeneration in the mammalian retina by promoting immune cell accumulation and inhibiting neurogenic potential.

Visualizing cell death in live retina: Using calpain activity detection as a biomarker for retinal degeneration

The paper demonstrates that calpain activity can be detected in live retinal tissue as a biomarker for retinal degeneration, showing distinct temporal activity patterns of calpain isoforms during photoreceptor cell death.

Targeting ON-bipolar cells by AAV gene therapy stably reverses LRIT3-congenital stationary night blindness

This paper demonstrates that AAV gene therapy targeting ON-bipolar cells in a canine model of LRIT3-CSNB significantly improves night vision and restores LRIT3 function.

Müller Glia regenerative potential is maintained throughout life despite neurodegeneration and gliosis in the ageing zebrafish retina

The paper shows that aged gliotic Müller glia in zebrafish retain regenerative potential and can be stimulated to repair damaged neurons despite age-related neurodegeneration.

Inhibiting retinoic acid mitigates vision loss in a mouse model of retinal degeneration

The paper shows that inhibiting retinoic acid (RA) reduces retinal ganglion cell (RGC) hyperactivity and improves image detection in a mouse model of retinal degeneration.

Subcellular localization of mutant P23H rhodopsin in an RFP fusion knockin mouse model of retinitis pigmentosa

This study creates a mouse model of retinitis pigmentosa with a P23H-Rho-RFP fusion to study subcellular localization and disease progression, finding slow retinal degeneration and ER accumulation of mutant protein.

mTOR activity is essential for retinal pigment epithelium regeneration in zebrafish

This study shows that mTOR activity is necessary and sufficient for RPE regeneration in zebrafish, with immune cell interactions playing a key role in this process.

The Musashi proteins are post-transcriptional activators of protein expression and alternative exon splicing in vertebrate photoreceptors

This study identifies Musashi proteins as essential regulators of protein expression and alternative splicing in photoreceptors, revealing their dual nuclear and cytoplasmic functions.

Multi-omics profiling, in vitro and in vivo enhancer assays dissect the cis-regulatory mechanisms underlying North Carolina macular dystrophy, a retinal enhanceropathy

This study identifies cis-regulatory elements and non-coding variants associated with North Carolina macular dystrophy using multi-omics and enhancer assays.

Early Disruption of Photoreceptor Cell Architecture and Loss of Vision in a Humanized Pig Model of Usher Syndrome

This study creates a humanized pig model of Usher syndrome type 1, showing disrupted photoreceptor architecture and vision loss, and validates gene therapy approaches.

Rod-genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor compositions and progressive retinal degeneration

This study identifies mafba as a regulator of nrl-independent rod genesis in zebrafish and reveals a bipotent rod/green-cone precursor cell fate decision controlled by nrl.

Disruption of miR-18a alters proliferation, photoreceptor replacement kinetics, inflammatory signaling and microglia/macrophage numbers during retinal regeneration in zebrafish

This study shows that disrupting miR-18a in zebrafish retinas delays photoreceptor regeneration, increases proliferation, prolongs inflammation, and affects microglia/macrophage responses.