Wnt/β-catenin signaling in development and cancer

Intestinal stem cell renewal controlled by capillary morphogenesis gene 2 following injury

This study shows that CMG2 is essential for intestinal stem cell renewal after injury, as its loss impairs stem cell regeneration and Wnt signaling in mice.

Frizzled1 and Frizzled2 are not redundant for competitive survival under low-Wingless levels in the developing Drosophila wing epithelium

This study shows Frizzled2 is essential for cell survival under low-Wingless conditions, while Frizzled1 is not, revealing non-redundant roles in Drosophila wing development.

A transphyletic study of metazoan β-catenin protein complexes

This study compares β-catenin sequences and function across nonbilaterian metazoans and Xenopus embryos, revealing conserved structural and functional properties of β-catenin complexes.

Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis

The paper identifies distinct and overlapping roles of dact1 and dact2 in regulating noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial development.

A homozygous human WNT11 loss-of-function variant associated with laterality, heart and renal defects

The paper identifies a homozygous WNT11 variant causing laterality, heart, and renal defects in an infant and shows its loss-of-function in Xenopus embryos.

Distinct functions of three Wnt proteins control mirror-symmetric organogenesis in the C. elegans gonad

The paper shows that three Wnt proteins control the polarity of somatic gonadal precursors in C. elegans, which is essential for mirror-symmetric gonad development.

Functional analysis of the Nematostella Wnt/β-catenin destruction complex provides insight into the evolution of a critical regulatory module in a major metazoan signal transduction pathway

The paper investigates the evolution of the Wnt/β-catenin destruction complex in Nematostella vectensis, showing it functions similarly to bilaterians despite lacking conserved domains, suggesting an ancestral low-affinity binding mechanism.

UVB radiation suppresses Dicer expression through β-catenin

This study shows UVB radiation reduces Dicer expression via activation of the WNT/β-catenin pathway and direct transcriptional repression.

Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL

This study shows Wnt induces FZD5/8 endocytosis and degradation via ZNRF3/RNF43, with RSPO1 stabilizing FZD5/8 and DVL promoting ligand-independent endocytosis.

Robinow Syndrome DVL1 variants disrupt morphogenesis and appendage formation in a Drosophila disease model

This study investigates the effects of a DVL1 variant in a Drosophila model of Robinow Syndrome, showing disrupted morphogenesis and appendage formation with increased cell death and basement membrane changes.

A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia

This study identifies an enhancer of Ctnnb1 that regulates Wnt signaling dosage, maintaining intestinal homeostasis and suppressing colorectal cancer.

Caenorhabditis elegans SEL-5/AAK1 regulates cell migration and cell outgrowth independently of its kinase activity

This study shows SEL-5/AAK1 regulates cell migration and outgrowth in C. elegans without requiring kinase activity, and identifies Wnt signaling components involved in these processes.

The fate of secretory cells during intestinal homeostasis, regeneration, and tumor formation is regulated by Tcf4

This study investigates the role of Tcf4 in intestinal epithelial regeneration and tumorigenesis using mouse models and RNA sequencing, finding that Tcf4 loss shifts cell lineage from Paneth to goblet cells and affects tumor cell phenotypes.

E3 ubiquitin ligase Deltex facilitates the expansion of Wingless gradient and antagonizes Wingless signaling through a conserved mechanism of transcriptional effector Armadillo/β-catenin degradation

This study identifies Deltex as a regulator of Wg signaling by modulating the gradient and degradation of Armadillo/β-catenin across species.

Semaphorin Receptors Antagonize Wnt Signaling Through Beta-Catenin Degradation

This study shows that Semaphorin receptors antagonize Wnt signaling by promoting beta-catenin degradation, independent of primary cilia.

Olive phenolic compounds, potent tankyrase 1 inhibitor exhibit anti colon cancer effects by blocking Wnt/β-catenin pathway

This study identifies olive polyphenols as tankyrase 1 inhibitors that suppress the Wnt/β-catenin pathway, reducing colon cancer cell viability and target gene expression.

The Drosophila EcR-Hippo component Taiman promotes epithelial cell fitness by control of the Dally-like glypican and Wg gradient

The paper shows that Taiman promotes epithelial cell fitness by controlling the Wg gradient through Dally-like glypican, leading to cell competition in Drosophila wing discs.

Wnt signaling modulates the response to DNA damage in the Drosophila wing imaginal disc by regulating the EGFR pathway

This study shows that Wnt signaling in Drosophila wing imaginal discs reduces apoptosis caused by DNA damage by modulating the EGFR pathway through Rhomboid and DDR components.

LSD1 controls a nuclear checkpoint in Wnt/β-catenin signaling to regulate muscle stem cell self renewal

This study identifies LSD1 as a regulator of Wnt/β-catenin signaling by demethylating β-catenin to prevent its degradation, thereby influencing muscle stem cell self-renewal.

Stabilization of epithelial β-catenin compromises mammary cell fate acquisition and branching morphogenesis

This study shows that stabilizing β-catenin in mammary epithelium impairs branching morphogenesis and promotes epidermal differentiation over hair follicle fate.

The Developmental Transcription Factor TBX3 Physically Engages with the Wnt/β-catenin Transcriptional Complex in Human Colorectal Cancer Cells to Regulate Metastasis Genes

This study identifies TBX3 as a functional component of the Wnt/β-catenin complex in human colorectal cancer, showing it modulates metastasis-related transcription through direct protein interactions.

Single Cell Transcriptomics identifies a WNT7A-FZD5 Signaling Axis that maintains Fallopian Tube Stem Cells in Patient-derived Organoids

The paper identifies a WNT7A-FZD5 signaling axis critical for human fallopian tube stem cell self-renewal using single-cell transcriptomics and organoid models.

Loss of Nkd1 is epistatic to loss of Axin2 in regulating Wnt signaling

This study shows that loss of Nkd1 is epistatic to loss of Axin2 in Wnt signaling regulation in zebrafish, with double mutants resembling Nkd1 single mutants.

Beta-catenin-mediated activation of Wnt target genes utilizes a biomolecular condensate-dependent mechanism

This study shows that beta-catenin's ability to form biomolecular condensates is essential for its role in Wnt target gene regulation.

BRAIDing receptors for cell specific targeting

The paper introduces a cell-specific targeting strategy called BRAID, validated using the WNT/{beta}-catenin system, showing it can induce signaling specifically on hepatocytes.

Prickle and Ror modulate Dishevelled-Vangl interaction to regulate non-canonical Wnt signaling during convergent extension

CK2α-dependent regulation of Wnt activity governs white matter development and repair

This study identifies CK2-dependent phosphorylation of Daam2 as a regulatory mechanism controlling oligodendrocyte development and myelin repair through Wnt signaling.

The PMA Phorbol Ester Tumor Promoter Increases Canonical Wnt Signaling Via Macropinocytosis

This study shows that PMA enhances Wnt signaling through macropinocytosis, with implications for cancer progression.

A Van Gogh/Vangl tyrosine phosphorylation switch regulates its interaction with core Planar Cell Polarity factors Prickle and Dishevelled

The paper shows that phosphorylation of a specific tyrosine in Vang/Vangl regulates its interaction with Pk and Dsh/Dvl, promoting the formation of the Vang/Vangl-Pk complex during PCP establishment.

Wnt signaling couples G2 phase control with differentiation during hematopoiesis

This study shows that Wnt6/EGFR signaling controls progenitor growth, proliferation, and differentiation by regulating G2 phase and cell-cycle exit through both β-catenin-dependent and -independent pathways in Drosophila hematopoiesis.