Wnt/β-catenin signaling in development and cancer

XPO1 inhibition modulates the Wnt/β-catenin signaling pathway to reduce colorectal cancer tumorigenesis.

This paper shows Eltanexor, an XPO1 inhibitor, reduces COX-2 and Wnt/β-catenin signaling in CRC, decreasing tumor burden in Apcmin/+ mice.

Asperous coordinates regenerative timing by regulating damage-induced WNT Signaling

The paper identifies Asperous as a regeneration-specific regulator that controls WNT signaling timing during tissue repair in Drosophila.

A novel conserved protein associates with the IFT-A complex to mediate nuclear translocation of β-catenin in Wg/Wnt-signaling

This study identifies a novel conserved protein, Pasovec, that interacts with the IFT-A complex to facilitate nuclear translocation of β-catenin in Wg/Wnt signaling.

BCAS2 promotes primitive hematopoiesis by sequestering β-catenin within the nucleus

This study identifies BCAS2's role in promoting primitive hematopoiesis by enhancing β-catenin nuclear retention through direct binding.

MEK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesis

This study shows MEK1/2 inhibitors reduce AXIN1 levels in CRC by mTOR-dependent translational repression, not by affecting protein stability.

SP1 amplifies the effects of cellular proliferation via the Wnt/β-catenin pathway in colon development and cancer

This study shows that SP1 enhances Wnt/β-catenin pathway effects on cell proliferation in colon development and cancer, with conserved roles in both contexts.

GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche via stromal remodelling

Pathological epithelial GREM1 expression induces therapeutically reversible ectopic stem cell niches through stromal remodelling.

Nuclear localization and transactivation of SYS-1/β-catenin is the result of serial gene duplications and subfunctionalizations

This study investigates the evolution of beta-catenin paralogs in C. elegans, showing that SYS-1 compensates for missing domains through novel transactivation and nuclear localization mechanisms.

Quantification of Wnt3a, Wnt5a and Wnt16 Binding to Multiple Frizzleds Under Physiological Conditions using NanoBit/BRET

This study quantifies binding affinities of Wnt3a, Wnt5a, and Wnt16 to Frizzled receptors using NanoBRET in living cells, revealing LRP6's role in modulating these interactions.

The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of β-catenin stability

This study identifies HUWE1 as a regulator of WNT signaling through two mechanisms: antagonizing destruction complex-mediated β-catenin degradation and an independent pathway, both requiring HUWE1's ubiquitin ligase activity.

Class III PI3K is essential for Wingless secretion and Evi/Wls recycling in Drosophila

The paper identifies Vps15 as essential for endocytosis-dependent Wg secretion and reveals divergent post-endocytic fates of Wg and Evi/Wls in Drosophila.

Dishevelled localization and function are differentially regulated by structurally distinct sterols

This study shows that different sterols affect DVL2 localization and function through specific structural interactions, impacting cell signaling and homeostasis.

Mesenchymal WNT2B is Required for the Development and Function of the Human Intestine

This study identifies mesenchymal WNT2B as critical for human intestinal epithelial development and function using patient-derived organoids and transcriptomic analysis.

Wnt5a and Notum Influence the Temporal Dynamics of Cartilaginous Mesenchymal Condensations in Developing Trachea.

This study investigates the role of Notum and Wnt5a in regulating the timing of cartilaginous mesenchymal condensations in developing trachea, showing their impact on chondrogenesis and tracheal lumen formation.

Palmdelphin facilitates R-spondin2 secretion to activate Wnt signaling and promote colorectal cancer stemness and tumorigenesis

This study identifies Palmdelphin as a marker of colorectal cancer stem cells that promotes tumorigenesis by facilitating R-spondin2 secretion and Wnt signaling activation.

Wnt/Beta-Catenin Signaling Is Active in Neuroendocrine Prostate Cancer

This study investigates Wnt/beta-Catenin signaling in neuroendocrine prostate cancer, finding elevated pathway activity and potential therapeutic targeting.

Armed with PRICKLE(3)s: Stabilizing WNT/PCP complexes against RNF43-mediated ubiquitination

This study identifies PRICKLE3's role in stabilizing WNT/PCP complexes by inhibiting RNF43-mediated ubiquitination of VANGL1/2.

Compound screening in primary human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies

The paper screens 1,429 compounds in primary human airway basal cells to identify Wnt pathway activators that promote proliferation and regeneration.

APC loss promotes intestinal transformation through induction of bistable stem cell states

This study identifies that APC loss in colorectal cancer drives a β-CATENIN-independent fetal intestinal transcriptional program through YAP activation, leading to bistable stem cell states and enhanced tumorigenesis.

A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression

The paper identifies a TNKS2-selective inhibitor that enables tumor-selective WNT suppression by exploiting 8p loss in cancer cells.

Noncanonical Wnt/Ror2 Signaling Regulates Basal Cell Fidelity and Branching Morphogenesis in the Mammary Gland

This study shows that noncanonical Wnt signaling via Ror2 maintains basal cell identity in mammary glands, preventing fate transitions to luminal cells and ensuring proper branching morphogenesis.

Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors

This study identifies C-8 position substitutions in quinazolin-4-ones that enhance the potency and selectivity of tankyrase inhibitors by improving interactions with TNKS2.

Modulation of β-Catenin is important to promote WNT expression in macrophages and mitigate intestinal injury

This study shows that modulating β-Catenin in macrophages increases WNT expression, and WNT-enriched EVs from these macrophages reduce intestinal injury.

Human colon stem cells are the principal epithelial responders to bacterial antigens

The paper investigates how human intestinal epithelial cells respond to bacterial antigens, finding that stem cells are the primary responders and that WNT signaling plays a key role in regulating microbial responses.

Gas1-Mediated Suppression of Hepatoblastoma Tumorigenesis

The paper identifies Gas1 as a suppressor of hepatoblastoma tumorigenesis by showing its restoration inhibits tumor growth in mice and cell lines, and identifies a common set of B-Y-N regulated genes.

Dynamic Reprogramming of Stromal Pdgfra-expressing cells during WNT-Mediated Transformation of the Intestinal Epithelium

The paper shows Pdgfra+ fibroblasts reprogram during WNT-driven oncogenesis to promote a regenerative state in the epithelium, facilitating tumor formation.

Proximity interactomics identifies RAI14, EPHA2 and PHACTR4 as essential components of Wnt/planar cell polarity pathway in vertebrates

The paper identifies RAI14, EPHA2, and PHACTR4 as essential components of the Wnt/PCP pathway in vertebrates through BioID and zebrafish loss-of-function studies.

SYS-1/beta-catenin inheritance and regulation by Wnt-signaling during asymmetric cell division.

The paper quantifies SYS-1 inheritance during asymmetric cell division in C. elegans and shows its regulation by centrosomal processing and Wnt signaling in both mother and daughter cells.

Condensate screening identifies YM155 as β-catenin condensate inhibitor in colorectal cancer

The paper identifies YM155 as a β-catenin condensate inhibitor using a NECO screening platform, showing its anti-proliferative effect on WNT-driven colorectal cancer organoids.

Image-based screens identify regulators of endogenous Dvl2 biomolecular condensates

The paper identifies regulators of Dvl2 biomolecular condensates using image-based screens and phosphoproteomics, finding CK1δ/ε inhibition blocks condensate formation and modulates Wnt signaling.