TGF-β signaling in diseases

SMURF1/2 are novel regulators of WNK1 stability

The paper identifies SMURF1/2 as regulators of WNK1 stability and shows their interaction with WNK1 and its role in TGF-beta signaling.

The BMP2 prodomain promotes dimerization and cleavage of BMP6 homodimers and BMP2/6 heterodimers in vivo

This study shows the BMP2 prodomain enables dimerization and cleavage of BMP6 homodimers and BMP2/6 heterodimers in Xenopus embryos.

MAPK Phosphatase-5 is required for TGF-β signaling through a JNK-dependent pathway

This study shows MKP-5 promotes TGF-β signaling via JNK-dependent pathway by affecting SMAD2 phosphorylation and fibrogenic gene activation.

Liebig's law of the minimum in the TGF-β/SMAD pathway

The paper shows that TGF-β signaling responses are determined by the receptor with the lowest abundance, following Liebig's law of the minimum, across cell types and single cells.

Structural Basis of Non-Latent Signaling by the Anti-Mullerian Hormone Procomplex

This study reveals the structural basis of AMH procomplex signaling, showing how the prodomain maintains activity through a unique conformational mechanism.

Fibrotic Extracellular Matrix Preferentially Induces a Partial Epithelial-Mesenchymal Transition Phenotype in a 3-D Agent Based Model of Fibrosis

This paper develops a 3-D agent-based model of fibrosis to show that fibrotic ECM promotes a partial EMT state through TGF-β1-FN tethering, independent of TGF-β1 concentration.

Convergent Insulin and TGF-β signalling drives cancer cachexia by promoting aberrant fatbody ECM accumulation in a Drosophila tumour model

This study identifies insulin and TGF-β signaling convergence in Drosophila adipose tissue that drives ECM accumulation and muscle wasting in a tumor model.

Molecular mechanisms controlling the biogenesis of the TGF-β signal Vg1

This study identifies molecular mechanisms and motifs governing Vg1 biogenesis and introduces a Synthetic Processing system for programmed protein cleavage.

Endothelial Cell SMAD6 Balances ACVRL1/Alk1 Function to Regulate Adherens Junctions and Hepatic Vascular Development

This study shows SMAD6 in endothelial cells balances ALK1 signaling to regulate vascular development and junction integrity, preventing hemorrhage and vascular defects in the embryonic liver.

Positive and negative feedback regulation of the TGF-β1-SMAD4 axis explains two equilibrium states in human skin aging

This study identifies THBS1 and FMOD as positive and negative regulators of the TGF-β1-SMAD4 axis in human skin aging, revealing two equilibrium states through mathematical modeling and omics analyses.

A novel TGF-β-responsive enhancer regulates SRC expression and epithelial-mesenchymal transition-associated cell migration

This study identifies a TGF-β-responsive enhancer that upregulates SRC expression, driving EMT and cell migration in breast cancer.

SETD2 deficiency promotes renal fibrosis through the TGF-β/Smad signaling pathway in the absence of VHL

This study shows that SETD2 deficiency promotes renal fibrosis by activating the TGF-β/Smad signaling pathway in VHL-deficient mice.

The context-dependent, combinatorial logic of BMP signaling

The paper investigates how BMP ligands interact combinatorially and context-dependently through receptor expression, revealing equivalence groups and a biochemical model for signaling complex formation.

TGF-β-R2 is required for HBP induced acute lung injury and vascular leakage for TGF-/Smad/Rho signaling pathway activation

This study shows HBP binds to TGF-β-R2, activating the TGF-β/SMAD2/3 pathway to cause acute lung injury and vascular leakage.

Airway tissue stem cells reutilize the embryonic proliferation regulator, Tgfβ-Id2 axis, for tissue regeneration

This study identifies the Tgfβ-Id2 axis as a regulator of proliferation transitions in airway basal cells during development and regeneration, showing its role in tissue repair and potential in preventing hyperplasia.

Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes

This paper investigates the dimer/monomer propensities of Smad MH1-DNA complexes using structural biology methods, revealing that loop1 sequence determines dimerization and influencing Smad complex composition and DNA motif recognition.

Canonical and noncanonical TGF-β signaling regulate fibrous tissue differentiation in the axial skeleton

This study shows TGF-β regulates fibrous tissue markers in sclerotome via both canonical Smad3 and noncanonical ERK1/2 pathways, with Scleraxis acting as an intermediate.

Inhibition of USP4 attenuates epithelial-mesenchymal transition of renal tubular epithelial cells by TβRI

This study shows that USP4 promotes TGF-β1-induced EMT in renal tubular epithelial cells, contributing to renal interstitial fibrosis.

Optogenetic control of the Bone Morphogenetic Protein signalling pathway through engineered blue light-sensitive receptors

This paper develops an optogenetic system to control BMP signaling using blue light, enabling precise and dynamic activation in human cells.

Selective disruption of synaptic BMP signaling by a Smad mutation adjacent to the highly conserved H2 helix

The paper investigates how mutations in the Smad protein affect synaptic and nuclear BMP signaling in Drosophila, identifying a conserved structural feature critical for non-canonical signaling.

LncRNA GAS5 attenuates fibroblast activation through inhibiting Smad3 signaling

This study identifies GAS5 as a regulator of TGF-β-induced fibroblast activation by inhibiting Smad3 signaling, showing therapeutic potential for fibrotic diseases.

Proliferation control of kidney interstitial cells

This study shows that TGFβ/Smad signaling controls interstitial cell proliferation in the neonatal kidney by inhibiting Wnt/β-catenin signaling to prevent over-proliferation.

TGF-β Family Inhibitors Blunt Adipogenesis Via Non-Canonical Regulation Of SMAD Pathways

The paper investigates how TGF-β family inhibitors regulate adipogenesis by modulating SMAD pathways in 3T3-L1 cells, identifying mechanisms that suppress adipocyte formation.

Angiocrine FSTL1 insufficiency leads to atrial and vein wall fibrosis via SMAD3 activation

This study shows that loss of endothelial FSTL1 causes atrial and vein wall fibrosis through SMAD3 activation, leading to heart failure.

FOXC1 negatively regulates BMP-SMAD activity and Id1 expression during osteoblast differentiation.

This study shows FOXC1 inhibits BMP4 signaling by suppressing Id1 expression and SMAD activity, thereby regulating osteoblast differentiation.

Quantitative relationships between SMAD dynamics and target gene activation kinetics in single live cells

The paper quantifies how SMAD4 and SMAD2 dynamics relate to ctgf gene activation kinetics in single cells using live imaging and temporal analysis.

RLIM enhances BMP signalling mediated fetal lung development in mice

This study shows that RLIM deficiency in mice causes respiratory distress and neonatal death due to impaired BMP signaling in lung development.

The C. elegans SMOC-1 protein acts cell non-autonomously to promote bone morphogenetic protein signaling

This study identifies SMOC-1 as a positive modulator of BMP signaling in C. elegans, showing it acts cell non-autonomously and is evolutionarily conserved.

Caenorhabditis elegans BMP Transcriptional ProgramImplicates Collagen Genes in Body Size Regulation

The paper identifies cuticle collagen genes as downstream effectors of the DBL-1/BMP pathway in regulating body size in C. elegans and shows direct regulation through Smad binding elements.

Pathway crosstalk enables cells to interpret TGF-β duration

The paper shows that TGF-β signaling duration is interpreted through pathway crosstalk that controls SNAIL1 expression.