B. Wu

Structural basis for ligand recognition and G protein-coupling promiscuity of the cholecystokinin A receptor

The paper presents cryo-EM structures of CCKAR with different G proteins to elucidate its G protein coupling promiscuity and ligand recognition mechanism.

ORAI1 establishes resistance to SARS-CoV-2 infection by regulating tonic type I interferon signaling

This study shows ORAI1 regulates baseline type I interferon signaling, affecting resistance to SARS-CoV-2 infection.

A temperate Siphoviridae bacteriophage isolate from Siberian tiger enhances the virulence of Methicillin-resistant Staphylococcus aureus through distinct mechanisms

This study isolates a temperate Siphoviridae bacteriophage from a Siberian tiger that enhances MRSA virulence through gene upregulation without carrying virulence or resistance genes.

Population genomics of Salmonella enterica serovar Weltevreden ST365, an emerging predominant causative agent of diarrheal disease

This study identifies ST365 as the predominant causative agent of S. Weltevreden diarrhea outbreaks globally and discovers a novel virulence plasmid associated with its pathogenicity.

Amphipathic Bax core dimer forms part of apoptotic pore wall in the mitochondrial membrane

This study determines the structure of the Bax core dimer and shows it forms part of the mitochondrial pore wall during apoptosis.

RAD51AP1 mediates RAD51 activity through nucleosome interaction

This study shows RAD51AP1 binds nucleosomes and aids RAD51 in chromatin-mediated DNA repair by facilitating donor DNA capture and joint-molecule formation.

Maximum Antigen Diversification in a Lyme Bacterial Population and Evolutionary Strategies to Overcome Pathogen Diversity

The paper shows evolution-based synthetic antigen designs can overcome pathogen diversity by generating broadly reactive OspC analogs against Lyme disease strains.

Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia

The paper identifies leukemia stemness and co-occurring mutations as drivers of resistance to IDH inhibitors in AML through genomic analyses of treated patients.

Defects in plant immunity modulate the rates and patterns of RNA virus evolution

This study shows that host immunity differences affect RNA virus evolution rates and patterns, with resistant hosts driving faster adaptation and permissive hosts selecting for specialist viruses.

Structural and biochemical mechanisms of NLRP1 inhibition by DPP9

This study identifies the structural and biochemical mechanism by which DPP9 inhibits NLRP1, preventing its activation and maintaining it in an auto-inhibited state.

Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8

This study reveals the structural mechanisms by which NLRP1 and CARD8 assemble distinct inflammasome complexes through unique CARD domain interactions.

Dynamic regulation of translation quality control associated with ribosome stalling

The paper develops a SunTag-based reporter to study ribosome stalling during translation of poly(A)-containing mRNAs and finds that stalled ribosomes are slowly cleared by quality control machinery, targeting nascent proteins rather than mRNA.

Cryo-EM Structure of Native Human Uromodulin, a Zona Pellucida Module Polymer

The paper reports the cryo-EM structure of native human uromodulin, revealing its filamentous conformation and mechanism of bacterial binding.

Dual located WHIRLY1 affects salicylic acid homeostasis via coordination of ICS1, 1 PAL1 and BSMT1 during Arabidopsis plant aging

The paper shows that dual localization of WHIRLY1 affects salicylic acid homeostasis by regulating ICS1, PAL1, and BSMT1 during Arabidopsis aging, leading to altered senescence phenotypes.

DNA methylation is indispensable for leukemia inhibitory factor dependent embryonic stem cells reprogramming

This study shows that LIF alone can reprogram 2i/LIF cultured ESCs to hypermethylated ESCs, demonstrating DNA methylation's essential role in LIF-dependent reprogramming and self-renewal.

Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance

This study shows that Aire's CARD-mediated multimerization forms nuclear foci and affects transcriptional activity, but also increases susceptibility to PML body interactions, which can impair its function.

Lower Soil Carbon Loss Due to Persistent Microbial Adaptation to Climate Warming

This study shows that microbial adaptation reduces soil carbon loss under long-term warming by decreasing temperature sensitivity of respiration.

Gut Microbiome Biomarkers in Adolescent Obesity：a Regional Study

This study identifies gut microbiome biomarkers associated with obesity in Shenzhen adolescents and finds gender-specific differences in microbiome composition and function.

Prognostic Role of c-Met Overexpression in High Grade Glioma: a Meta-analysis

This study evaluates the prognostic role of c-Met overexpression in high-grade glioma through meta-analysis and finds it correlates with poor progression-free survival but not overall survival.

Effect of Alpha-Lactalbumin and Lactoferrin Oleic Acid Complexes on Chromatin Structural Organization

This study investigates the structural properties of alpha-lactalbumin and lactoferrin oleic acid complexes and their interaction with chromatin, suggesting potential anti-tumor mechanisms.

Biochemical and structural characterization of a highly active branched-chain amino acid aminotransferase from Pseudomonas sp. for efficient biosynthesis of chiral amino acids

This study characterizes PsBCAT, a branched-chain amino acid aminotransferase from Pseudomonas sp., showing broad substrate specificity and high activity, and demonstrates its application in efficient chiral amino acid synthesis.

Application of clinical genomic sequencing among Chinese advanced cancer patients to guide precision medicine decisions

This study evaluates the impact of clinical genomic sequencing (CWES) on treatment outcomes for Chinese stage IV cancer patients, finding improved progression-free survival in those following CWES recommendations.

Isoform switching as a mechanism of acquired resistance to isocitrate dehydrogenase inhibition

The paper identifies isoform switching between mutant IDH1 and IDH2 as a mechanism of acquired resistance to IDH inhibitors in cancers.

Comprehensive analysis of potential immunotherapy genomic biomarkers in 1,000 Chinese patients with cancer

This study analyzes four genomic biomarkers in 1,000 Chinese cancer patients to assess their distribution and associations with cancer types and mutations.

Re-targeting of macroH2A following mitosis to cytogenetic-scale heterochromatic domains

This study shows that macroH2A re-targets to heterochromatic domains in G1 phase after DNA replication, maintaining epigenetic memory through cell division.

Structural Basis For The Specific Recognition Of DSR By The YTH Domain Containing Protein Mmi1

The paper reports the crystal structure of the YTH domain of Mmi1 bound to DSR-containing RNA, revealing the mechanism of specific RNA recognition and its distinct function compared to other YTH domain proteins.

Molecular Basis For The Specific And Multivariate Recognitions Of RNA Substrates By Human hnRNPA2/B1

This study determines the crystal structures of hnRNPA2/B1's RRM domains bound to RNA substrates, revealing sequence-specific recognition and suggesting a matchmaker mechanism, but not m6A binding.