D. Yang

RNA helicase DDX5 enables STAT1 mRNA translation and interferon signaling in hepatitis B virus replicating hepatocytes

This study shows DDX5 resolves a G-quadruplex in STAT1 mRNA 5UTR, enabling STAT1 translation and interferon signaling in HBV-infected hepatocytes.

DNA nanoswitch barcodes for multiplexed biomarker profiling

This paper introduces DNA nanoswitch barcodes for multiplexed detection of up to 6 biomarkers in a single assay, demonstrating mixed multiplexing of DNA, RNA, antibody, and protein.

Ca2+ and Membrane Potential Transitions During Action Potentials are Self-Similar to Each Other and to Variability of AP Firing Intervals Across the Broad Physiologic Range of AP Intervals During Autonomic Receptor Stimulation

The paper shows that Ca2+ and membrane potential transitions during action potentials in SAN cells are self-similar across species and autonomic stimulation, indicating long-range correlations in their kinetic behavior.

Impaired cytotoxic CD8+ T cell response in elderly COVID-19 patients

This study examines CD8+ T cell cytotoxicity in mild COVID-19 patients, finding reduced cytotoxic potential in elderly individuals over 80 years old.

A comprehensive transcriptome signature of murine hematopoietic stem cell aging

The paper identifies a core transcriptional aging signature in murine hematopoietic stem cells, showing increased membrane-associated gene expression and age-related heterogeneity.

Oral delivery of SARS-CoV-2 DNA vaccines using attenuated Salmonella typhimurium as a carrier in rat

This study demonstrates that attenuated Salmonella typhimurium can deliver SARS-CoV-2 spike protein DNA to rats, inducing humoral immunity against SARS-CoV-2.

Transcriptomic and morphological response of SIM-A9 mouse microglia to carbon nanotube neuro-sensors

The paper examines the effects of SWCNT dopamine nanosensors on mouse microglia and introduces a passivation strategy to enhance biocompatibility and imaging performance.

A critical role for MSR1 in vesicular stomatitis virus infection of the central nervous system

This study shows that MSR1 promotes VSV infection in the spinal cord by acting as a receptor, and its absence reduces viral load and mortality in mice.

Limited inhibition of multiple nodes in a driver network blocks metastasis

The paper shows that limited inhibition of multiple core pathways in a driver network effectively blocks metastasis in mouse breast cancer models.

Enteropathy-induced regulatory T cells inhibit intestinal CD4+ T cell responses against oral vaccines

This study shows that EED-induced Tregs suppress intestinal CD4+ T cell responses to oral vaccines, but not lymph node responses, and worsen stunting when depleted.

A sound strategy for homology modeling-based affinity maturation of a HIF-1α single-domain intrabody

This study develops a computational strategy for in silico nanobody affinity maturation, achieving a 17.5-fold improvement in binding affinity for an anti-HIF-1α nanobody.

STING deficiency-associated aberrant CXCL10 expression contributes to pathogenesis of arthritogenic alphaviruses

This study shows that STING deficiency increases CXCL10 expression, leading to higher viral loads and inflammation in alphavirus-induced arthritis in mice.

Novel non-transposable-element regulation patterns of KZFP family reveal new drivers of its rapid evolution

This study identifies new regulatory patterns of KZFP family zinc fingers that drive their rapid evolution by binding non-transposable element regions and positively regulating gene expression.

Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance

This study shows that Aire's CARD-mediated multimerization forms nuclear foci and affects transcriptional activity, but also increases susceptibility to PML body interactions, which can impair its function.

Chemical and structural investigation of the paroxetine-human serotonin transporter complex

The paper investigates the binding of paroxetine and its analogs to the serotonin transporter using structural and biochemical methods, revealing how they stabilize the outward-open conformation and inhibit serotonin transport.

Prophylactic and therapeutic HBV vaccination by an HBs-expressing cytomegalovirus vector lacking an interferon antagonist

This study shows that HBV vaccines based on modified CMV vectors can clear HBV in mice through enhanced CD8+ T cell responses in both prophylactic and therapeutic settings.

Stretching DNA to twice the normal length with single-molecule hydrodynamic trapping

This paper introduces a new single-molecule force spectroscopy method that stretches DNA to twice its normal length under high tension.

Protein Corona Composition and Dynamics on Carbon Nanotubes in Blood Plasma and Cerebrospinal Fluid

The paper measures protein corona formation on carbon nanotubes and polystyrene nanoparticles in blood plasma and cerebrospinal fluid, identifying key proteins and interactions driving corona composition and dynamics.

NFIA regulates granule recruitment and exocytosis in the adult pancreas

This study identifies NFIA as a regulator of granule recruitment and exocytosis in pancreatic cells, showing its role in insulin and enzyme secretion and linking it to metabolic disorders.

A novel G protein-biased and subtype selective agonist for a G protein-coupled receptor discovered from screening herbal extracts

This study identifies a novel G protein-biased and subtype-selective agonist for the 5-HT2C receptor from herbal extracts, showing efficacy in weight loss similar to lorcaserin.

Purification, identification, and characterization of two benzophenanthridine alkaloids from Corydalis longicalcarata rhizomes with anti-mitotic and polyploidy-inducing activities

This study identifies two benzophenanthridine alkaloids from Corydalis longicalcarata rhizomes with anti-mitotic and polyploidy-inducing activities through a phenotypic screen of medicinal plant extracts.

The effects of polydisperse crowders on the compaction of the Escherichia coli nucleoid

This study shows that macromolecular crowders significantly compact E. coli nucleoids, with volume decreasing 3-fold at 30% higher crowder concentration.

A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil

This paper identifies dimethylfasudil as a synthetic lethal compound for MYC-overexpressing cells through a high-content screen, showing its efficacy in rodent and human cell lines.

Ligand Entry into Fatty Acid Binding Protein via Local Unfolding instead of Gap Widening

This study shows that fatty acids enter FABP via local unfolding of helix 2, not gap widening, using a gap-closed variant and biophysical experiments.

The Dynamic Strength of the Hair-Cell Tip Link Reveals Mechanisms of Hearing and Deafness

This paper measures the dynamic mechanical properties of hair-cell tip links, revealing their role in hearing and deafness through single-molecule analysis.

Corona exchange dynamics on carbon nanotubes by multiplexed fluorescence monitoring

This study measures real-time DNA and protein exchange dynamics on carbon nanotubes in solution, showing fibrinogen binds more strongly than albumin and affects dopamine sensor response.

Bacterial T6SS Effector EvpP Inhibits Neutrophil Recruitment via Jnk-Caspy Inflammasome Signaling In vivo

This paper shows that the bacterial T6SS effector EvpP inhibits neutrophil recruitment by suppressing Jnk-Caspy inflammasome signaling in zebrafish larvae during infection.

Convergent genomic signatures of high altitude adaptation among domestic mammals

This study identifies convergent genomic signatures of high altitude adaptation in domestic mammals by analyzing 327 genomes, revealing positive selection in genes like EPAS1 and C10orf67.

Axon-like protrusions promote small cell lung cancer migration and metastasis

This study identifies axon-like protrusions in SCLC cells as drivers of migration and metastasis, linking neuronal programs to cancer progression.

Selective Activation of TASK-3-containing K+ Channels Reveals Their Therapeutic Potentials in Analgesia

The paper identifies CHET3, a selective TASK-3 activator, and demonstrates its analgesic effects in pain models, highlighting TASK-3 as a novel non-opioid analgesic target.