W. Yang

Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolopyrimidines as Potential Candidates to Treat Human African Trypanosomiasis

This study evaluates the structure-activity relationships, tolerability, and efficacy of microtubule-active triazolopyrimidines against Trypanosoma brucei, identifying two congeners with significant antiparasitic effects in vivo.

Insm1 regulates the development of mTECs and immune tolerance

This study shows that Insm1 regulates mTEC development and immune tolerance by interacting with Aire and affecting gene expression.

Single-cell transcriptional analysis of lamina propria lymphocytes in the jejunum reveals ILC-like cells in pigs

The paper identifies and characterizes ILC-like cells in porcine jejunum using scRNA-seq and flow cytometry, revealing subtype classifications and shared features with human ILCs.

Flexible and scalable control of T cell memory by a reversible epigenetic switch

The paper identifies a reversible epigenetic switch in T cells that controls memory potential, allowing flexible responses to pathogen virulence.

A pathogen effector FOLD diversified in symbiotic fungi

The paper uses structural modeling to show that FOLD proteins in symbiotic fungi are similar to pathogen effectors and are expressed during plant colonization.

Spatial transcriptome profiling of in vitro 3D tumouroids to study tumour-stroma interactions

This study uses spatial transcriptomics to analyze how different stromal cells affect gene expression and behavior in engineered ameloblastoma tumouroids.

Discovery of benzophenanthridine derivatives with potent activity against multidrug resistant Mycobacterium tuberculosis

This study identifies two benzophenanthridine derivatives with potent anti-Mtb activity, effective against multidrug-resistant strains and comparable to rifampicin.

A frameshift in Yersinia pestis rcsD leads to expression of a small HPt variant that alters canonical Rcs signalling to preserve flea-mammal plague transmission cycles

The paper shows a frameshift mutation in rcsD of Yersinia pestis produces a small Hpt variant that modifies Rcs signaling to support flea-mammal plague transmission.

Gonadal sex patterns p21-induced cellular senescence in mouse and human glioblastoma

The paper shows that gonadal sex influences p21-induced cellular senescence in GBM, contributing to sex differences in survival.

Basal type I interferon signaling has only modest effects on neonatal and juvenile hematopoiesis

This study shows that loss of type I interferon signaling in neonatal mice reduces immature blood progenitors but has minimal impact on postnatal hematopoiesis.

Transcellular progression of infection threads in Medicago truncatula roots is controlled by locally confined cell wall modifications

The paper investigates how rhizobia move through Medicago truncatula root cells by analyzing the role of SyPME and NPL in cell wall modifications during infection thread progression.

A common mechanism of temperature-sensing in thermoTRP channels

This study identifies a common mechanism for temperature sensing in TRPM8 and TRPV1 thermoTRP channels through water-protein interaction changes.

Modification-Dependent Restriction Endonuclease-based sequencing method (EcoWI-seq) maps the genome-wide landscape of phosphorothioate modification at base resolution.

The paper introduces EcoWI-seq, a method to map phosphorothioate modifications at base resolution in bacterial genomes, showing systematic usage of target sites in modified clones.

FIB-SEM analysis on three-dimensional structures of growing organelles in wild Chlorella pyrenoidosa cells

This study uses FIB-SEM to analyze 3D organelle structures in Chlorella pyrenoidosa during growth stages, revealing changes in mitochondria, chloroplasts, and starch grains.

A transcriptional complex of FtMYB102 and FtbHLH4 coordinately regulates the accumulation of rutin in Fagopyrum tataricum

This study identifies FtMYB102 and FtbHLH4 as a transcriptional complex that promotes rutin accumulation in Tartary buckwheat by inducing CHI expression.

The production of diverse brGDGTs by an Acidobacterium allows a direct test of temperature and pH controls on their distribution

This paper identifies an Acidobacterium that produces diverse brGDGTs and shows temperature primarily controls C5-methylation while cyclization is influenced by multiple factors.

Characteristics of N6-methyladenosine modification during sexual reproduction of Chlamydomonas reinhardtii

This study identifies m6A modification patterns and functions during sexual reproduction in Chlamydomonas reinhardtii, showing its role in regulating microtubule-based processes.

PP2A forestalls mitophagy by dephosphorylating Parkin and ubiquitin

This study identifies PP2A as a phosphatase that dephosphorylates Parkin and ubiquitin, thereby inhibiting mitophagy.

Phenethylamine-producing gut bacteria induces diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis

This study identifies Ruminococcus gnavus as a gut bacterium that contributes to IBS-D by increasing serotonin biosynthesis through phenethylamine production.

Structure of IgG-Fc hexamer reveals a mutual lock-and-key mode of Fc-Fc interaction

The paper determines the structure of an IgG-Fc hexamer using cryo-EM, revealing a mutual lock-and-key interaction mode between Fc domains.

Multiplexed imaging mass cytometry reveals distincttumor-immune microenvironments linked to immunotherapyresponses in melanoma

This study uses imaging mass cytometry to analyze tumor-immune microenvironments in melanoma patients, identifying distinct microenvironment archetypes linked to responses to anti-PD-1 therapy.

Epac1 regulates cellular SUMOylation by promoting the formation of SUMO-activating nuclear condensates

This study shows Epac1 regulates SUMOylation by forming nuclear condensates in response to cAMP, linking stress responses to SUMOylation dynamics.

Structural and functional impact by SARS-CoV-2 Omicron spike mutations

This study examines the structural, functional, and antigenic properties of the SARS-CoV-2 Omicron spike protein, revealing its enhanced immune evasion and altered fusogenic capability due to mutations.

An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoV-2 variants

This paper develops a biparatopic nanobody with broad neutralization against multiple SARS-CoV-2 variants, including Omicron, showing strong affinity and activity.

Two distinct binding modes provide the RNA binding protein RbFox with extraordinary sequence specificity

This study identifies two distinct binding modes of RbFox's RNA Recognition Motif that contribute to its high sequence specificity and functional diversity.

A slow dynamic switch regulates processing of microRNA-21

The paper identifies a slow conformational switch in pre-miR-21 that regulates its processing efficiency and shows how ligands can modulate this switch.

Deep learning methods for designing proteins scaffolding functional sites

This paper introduces two deep learning methods for designing proteins with specific functional sites, showing they can generate diverse proteins with desired properties.

Fast anther dehiscence state recognition system establishing by deep learning to screen heat tolerant cotton

The paper applies deep learning to identify anther dehiscence states in cotton to screen for heat-tolerant varieties and support genetic breeding research.

4DPhenoMVS: A Low-Cost 3D Tomato Phenotyping Pipeline Using a 3D Reconstruction Point Cloud Based on Multiview Images

This paper introduces 4DPhenoMVS, a low-cost 3D phenotyping pipeline for tomato plants using multiview images, showing high correlation with manual measurements and environmental impact on growth.

A Developmentally Prometastatic Niche to Hepatoblastoma in Neonatal Liver mediated by the Cxcl1/Cxcr2 Axis

This study identifies a neonatal liver niche that promotes hepatoblastoma metastasis via the Cxcl1/Cxcr2 axis, showing increased tumor aggressiveness and hypoxia in early postnatal models.