Epilepsy research and treatment

Photopharmacological activation of adenosine A1receptor signaling suppresses seizures in a mousemodel for temporal lobe epilepsy

This study demonstrates that photopharmacological activation of A1R reduces seizures in a mouse model of temporal lobe epilepsy with fewer side effects than systemic administration.

High-Resolution Multimodal Profiling of Human Epileptic Brain Activity via Explanted Depth Electrodes

This study uses explanted SEEG electrodes to integrate RNA sequencing, DNA methylation, and genomic data with electrophysiological recordings, revealing distinct molecular landscapes in epilepsies and identifying potential seizure zones.

Treatment effects in epilepsy: a mathematical framework for understanding response over time

This paper develops a dynamic network model to study how treatment affects seizure propensity over time in epilepsy, identifying potential prognostic markers for personalized treatment.

Loss of Slc35a2 alters development of the mouse cerebral cortex

This study shows that disrupting Slc35a2 in mouse cortical neurons causes altered neuronal migration and reduced seizure threshold, contributing to MOGHE-like features.

Modeling mTORopathy-related epilepsy in cultured murine hippocampal neurons using the multi-electrode array

This study models mTORopathy-related epilepsy in cultured murine hippocampal neurons using a multi-electrode array to identify network activity phenotypes and test drug treatments.

Feedback Control of Neuronal Excitability and Epileptiform Bursting using a Photocaged Adenosine A1 Agonist

This study uses a photocaged adenosine A1 agonist in a closed-loop system to control neuronal excitability and suppress epileptiform bursting in hippocampal slices.

Fine Mapping and Candidate Gene Analysis of Dravet Syndrome Modifier Loci on Mouse Chromosomes 7 and 8

This study refines two Dravet syndrome modifier loci in mice and identifies candidate genes that may influence disease severity.

Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability

The paper generates zebrafish models of candidate human epilepsy genes and identifies five genes associated with seizure-like behavior and hyperexcitability.

Circumscribing laser cuts attenuate seizure propagation in a mouse model of focal epilepsy

In a mouse model of focal epilepsy, sub-surface laser-produced cuts encircling the seizure focus attenuate propagation without behavioral impairment.

Preictal dysfunctions of inhibitory interneurons paradoxically lead to their rebound hyperactivity and to Low-Voltage-Fast onset seizures in Dravet syndrome.

The paper investigates seizure mechanisms in Dravet syndrome, finding that preictal dysfunctions of inhibitory interneurons lead to rebound hyperactivity and low-voltage-fast seizures.

Optimizing automated detection of high frequency oscillations using visual markings does not improve SOZ localization

This study evaluates whether optimizing automated HFO detection using visual markings improves SOZ localization accuracy, finding no significant improvement.

Knockdown of NeuroD2 leads to seizure-like behaviour, brain neuronal hyperactivity and a leaky blood-brain barrier in a Xenopus laevis tadpole model of DEE75

This study shows that reducing NeuroD2 activity in Xenopus laevis tadpoles causes seizure-like behavior, neuronal hyperactivity, and a leaky blood-brain barrier, supporting a haploinsufficiency model for DEE75.

Cellular contributions to ictal population signals

This study identifies the cellular sources of ictal population signals in seizures using calcium imaging and electrophysiology in mouse models.

Emerging neurodevelopmental mechanisms in patient induced pluripotent stem cells-derived spheroids modelling SCN1A Dravet Syndrome

This study uses patient-derived iPSC spheroids to model SCN1A Dravet Syndrome, revealing dysregulated developmental processes and predicting drug response to fenfluramine.

Spontaneous HFO Sequences Reveal Propagation Pathways for Precise Delineation of Epileptogenic Networks

The paper introduces an HFO-sequencing approach to analyze spontaneous HFOs in epilepsy patients, revealing propagation pathways and improving localization of epileptic tissue.

Altered hippocampal activation in seizure-prone CACNA2D2 knockout mice

This study examines hippocampal activation and histopathological changes in CACNA2D2 knockout mice, finding altered functional activity without significant structural changes associated with seizure susceptibility.

Effect of seizures on the severity of myelin vacuolization in a mouse model of megalencephalic leukoencephalopathy with subcortical cysts

This study investigates whether seizures exacerbate myelin vacuolization and astrocyte swelling in a mouse model of MLC, finding no significant acute worsening of these features.

Pharmaco-resistant temporal lobe epilepsy gradually perturbs the cortex-wide excitation-inhibition balance

This study shows that pharmaco-resistant temporal lobe epilepsy causes a progressive shift in cortical excitation-inhibition balance, linked to cognitive impairments and seizure frequency.

Human thalamic recordings reveal that epileptic spikes block sleep spindle production during non-rapid eye movement sleep

The paper shows that epileptic spikes during sleep block sleep spindle production in thalamic recordings of patients with epileptic encephalopathy.

Functional Assessment and Impact of Seizures on Cognitive Outcome in a Cohort of Individuals with KBG Syndrome

This study assesses the impact of seizures on cognitive outcomes in individuals with KBG syndrome using Vineland-3 assessments and medical records.

Activation of hypoactive parvalbumin-positive fast-spiking interneuron restores dentate inhibition to prevent epileptiform activity in the mouse intrahippocampal kainate model of temporal lobe epilepsy

This study investigates how parvalbumin-positive interneurons in the dentate gyrus change after status epilepticus and how their activity affects epileptiform activity in a mouse model of temporal lobe epilepsy.

Cell type specificity of mosaic chromosome 1q gain resolved by snRNA-seq in a case of epilepsy with hyaline protoplasmic astrocytopathy

The paper uses snRNA-seq to analyze mosaic chromosome 1q gain in a case of epilepsy with hyaline protoplasmic astrocytopathy, finding cell-type-specific gene expression changes in neurons and astrocytes.

Thalamic blood flow and EEG frequency band power during hyperventilation in idiopathic generalized epilepsy

This study examines the relationship between hyperventilation, EEG frequency band power, and thalamic blood flow in individuals with idiopathic generalized epilepsy compared to healthy controls.

PEACOC - Detecting and classifying a wide range of epileptiform activity patterns in rodents

PEACOC detects and classifies diverse epileptiform activity patterns in rodents, revealing a continuum of spike loads and an anti-correlation with granule cell dispersion.

Functional analysis of the epilepsy gene Pcdh19 using a novel conditional GFP-reporter mouse model

This paper develops a conditional Pcdh19 knockout mouse model with GFP reporter to study PCDH19's role in brain development and disease.

Selective medial septum lesions in healthy rats induce longitudinal changes in microstructure of limbic regions, behavioral alterations, and increased susceptibility to status epilepticus

This study shows that selectively lesioning GABAergic or cholinergic neurons in the medial septum of rats leads to behavioral changes and increased susceptibility to status epilepticus.

Causal Brain Network Evaluates Surgical Outcomes in Patients with Drug-Resistant Epilepsy

The paper uses causal brain network analysis of ECoG data to predict surgical outcomes in drug-resistant epilepsy patients, finding significant differences in causal connectivity in the alpha frequency band.

A worldwide ENIGMA study on epilepsy-related gray and white matter compromise across the adult lifespan

This study examines age-related changes in grey and white matter in TLE patients across the adult lifespan, finding accelerated aging effects after age 55.

Focal cortical dysplasia type II-dependent maladaptive myelination in the human frontal lobe

This study examines myelination patterns in FCD IIa and IIb in the frontal lobe, finding divergent maladaptive myelination features between the two subtypes.

Low frequency stimulation for seizure suppression: identification of optimal targets in the entorhinal-hippocampal circuit

This study identifies presynaptic targets in the entorhinal-hippocampal circuit that effectively suppress seizures using low-frequency stimulation in a mouse model of MTLE.