Acute Kidney Injury Research

Endothelial Prolyl Hydroxylase 3 Mitigates Maladaptive Inflammation to Promote Post-Ischemic Kidney Repair

This study identifies endothelial PHD3 as a regulator of kidney repair after ischemia, showing its role in suppressing inflammation and fibrosis through HIF-dependent mechanisms.

Long-chain polyphosphates induce glomerular microthrombi and exacerbate LPS-induced acute kidney injury in mouse

This study shows that long-chain polyphosphates cause kidney damage and worsen LPS-induced acute kidney injury in mice by forming microthrombi and increasing inflammation.

Early Lipid Remodeling During Ischemia Reperfusion Injury Is Associated with Damage- and Protection-Related Lipid Signatures in Acute Kidney Injury.

This study identifies lipid remodeling patterns in acute kidney injury, linking specific lipid signatures to injury and protection mechanisms.

Matrix Metalloproteinase (MMP) inhibition rescues endothelial glycocalyx damage and reduces neutrophil infiltration in sepsis-associated acute kidney injury

Stiffness sensing fuels matrix-driven metabolic reboot for kidney repair and regeneration

This study identifies Mfap2 as a key ECM component that regulates kidney repair by linking mechanical cues to metabolic reprogramming through Esr2-mediated transcriptional control.

Elucidation of Puberulic Acid-Induced Nephrotoxicity Using Stem Cell-based Kidney Organoids

This study uses kidney organoids to demonstrate that puberulic acid causes nephrotoxicity by inducing mitochondrial dysfunction and oxidative stress.

Quinolinic acid metabolism may mitigate AKI to CKD transition

This study identifies quinolinic acid as a mediator of kidney injury and fibrosis, suggesting it as a potential therapeutic target for preventing AKI-to-CKD progression.

Boolean Logic Coupled with Overrepresentation Analysis Reveals Activation of the Platelet-derived Growth Factor Receptor Beta Pathway in a Model of Oliguric Acute Kidney Injury; Implications for Transition to Chronic Kidney Disease

Photoacoustic imaging assessment of acute kidney injury associated with experimental necrotizing enterocolitis

This study assesses acute kidney injury in a neonatal rat model of necrotizing enterocolitis using photoacoustic imaging and finds reduced renal oxygen saturation as a non-invasive biomarker.

Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney

The paper presents a multi-modal atlas of human kidney disease, identifying cellular and spatial mechanisms of injury resolution or failure and linking them to clinical outcomes.

A kidney specific mouse model to study the effects of in vivo induction of Yamanaka factors

This study investigates the effects of in vivo induction of Yamanaka factors (OKS) in a kidney-specific mouse model to enhance tissue repair after acute kidney injury, finding that while feasible, it carries risks of oncogenic transformation.

Y665F variant of mouse Stat5b protects against acute kidney injury through transcriptomic shifts in renal gene expression

The paper investigates the protective role of the Stat5bY665F mutation in acute kidney injury using mouse models and transcriptomic analyses.

Interleukin enhancer binding factor 2 (Ilf2) and kidney epithelial stress resilience

This study identifies Ilf2 as a key regulator of kidney epithelial stress resilience through transcriptional and splicing programs in cultured cells and mouse models.

Pathophysiological response in experimental trauma-related acute kidney injury

This study develops a murine model of trauma-related acute kidney injury and identifies early renal stress responses and inflammatory changes.

High glucose levels impair the body's renal protective function during water deprivation by blunting the FXR-TonEBP axis

The paper shows high glucose levels reduce kidney protection during dehydration by inhibiting the FXR-TonEBP axis in diabetic patients and mice.

Human Urine-derived SIX2-positive renal progenitor cells improve kidney injury in an IRI mouse model

This study shows human urine-derived SIX2-positive renal progenitor cells reduce kidney fibrosis in an IRI mouse model but do not fully restore kidney function within 21 days.

Cell-Type Specific Single-Cell Signatures Reveal Nephrotoxic Drug Effects

The paper identifies cell-type specific single-cell signatures that reveal nephrotoxic drug effects and improves prediction of drug-induced kidney injury compared to bulk RNA sequencing.

The abscisic acid could reverse the cuproptosis in sepsis-associated acute kidney injury through the inhibition of ferredoxin-1

This study shows that abscisic acid reverses cuproptosis in sepsis-associated acute kidney injury by inhibiting ferredoxin-1.

Epithelial-Immune-Stromal Interactions Define Divergent Repair and Fibrosis Pathways After Acute Kidney Injury in Human Renal Transplants

This study identifies regenerative and fibrotic cell programs in human kidney transplants that determine outcomes of acute kidney injury.

Impact of nephrotoxins and oxidants on survival and transport function of hiPSC-derived renal proximal tubular cells

This study examines how nephrotoxins and oxidants affect the differentiation and function of iPSC-derived renal proximal tubular cells, finding that differentiating cells are highly sensitive to these agents.

Inhibition of methylthioadenosine phosphorylase provides protection from experimental acute kidney injury

This study shows that inhibiting MTAP reduces kidney injury markers and improves renal histology in AKI mouse models and links MTAP expression to kidney injury in human single-cell RNA sequencing data.

Loss of long-chain acyl-CoA dehydrogenase protects against acute kidney injury

This study shows that loss of LCAD protects against acute kidney injury by reducing oxidative stress and enhancing peroxisomal fatty acid oxidation.

Low Field Magnetic Resonance Imaging to Detect Acute Kidney Injury

This study uses EPR oximetry to assess kidney oxygen levels in mice with kidney injury, showing increased pO2 post-injury and high-resolution spatial mapping of oxygen distribution.

Protamine Protects Against Vancomycin Induced Kidney Injury

This study shows protamine delays vancomycin-induced kidney injury in rats by reducing urinary KIM-1 levels, without significantly inhibiting OAT1, OAT3, or OCT2.

Post-ischemic inactivation of HIF prolyl hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysis

This study shows that inactivating PHD enzymes in endothelial cells after ischemic kidney injury promotes maladaptive repair through glycolysis and MCT4, which can be reversed by MCT4 inhibitors.

The preferential injury of outer renal medulla after ischemia-reperfusion relies on high oxidative metabolism

This study identifies the outer stripe of the outer medulla as the most metabolically active and injured region in the kidney during ischemia-reperfusion injury, showing propofol exacerbates this damage through mitochondrial and fatty acid oxidation impairment.

Removal of the catalytic subunit of DNA-protein kinase in the proximal tubules promotes DNA and tubular damage during kidney injury

This study shows that DNA-PKcs in proximal tubules reduces DNA damage during acute kidney injury but not chronic injury, with mixed effects on fibrosis.

Plasma proteome profiling for AKI biomarker candidates associated with first-line ART in people living with HIV in South Africa

This study identifies plasma proteins associated with ARV-associated nephrotoxicity in HIV patients in South Africa using proteomic analysis and machine learning.

Visualization of intracellular ATP dynamics in the whole kidney under pathophysiological conditions using the kidney slice culture system

The paper establishes a novel ATP imaging system using kidney slice cultures to study intracellular ATP dynamics under pathophysiological conditions and evaluates ATP synthesis pathways in different kidney cell types.

Identification of novel prognostic targets in acute kidney injury using bioinformatics and next generation sequencing data analysis

The paper identifies potential prognostic targets in acute kidney injury using bioinformatics analysis of NGS data from a GEO dataset.