Bone Metabolism and Diseases

Focal adhesion protein vinculin inhibits Mef2c-driven sclerostin expression in osteocytes to promote bone formation in mice

This study shows that vinculin inhibits Mef2c-driven sclerostin expression in osteocytes, promoting bone formation in mice by enhancing estrogen regulation.

Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration

The paper shows that osteoclast-mediated resorption of calcified tissue is essential for successful skeletal integration during axolotl limb regeneration.

Contrasting effects of Ksr2, an obesity gene, on trabecular bone volume and bone marrow adiposity

This study investigates the role of Ksr2 in bone health, finding it negatively regulates femoral bone mass and influences adipocyte differentiation over osteoblasts in the bone marrow.

Impaired ERK MAPK activation in mature osteoblasts enhances bone formation via the mTOR pathway

The paper shows that inhibiting ERK in mature osteoblasts enhances bone formation through mTOR pathway activation, revealing a dual role of ERK in osteoblast differentiation.

Mathematical modeling of the effects of Wnt-10b on bone metabolism

The paper models the effects of Wnt-10b on bone metabolism using differential equations and validated parameters from mouse data, predicting increased pre-osteoblasts and osteoblasts and decreased osteoclasts.

ATP6AP2-to-MMP14, a key pathway for osteoblast to osteocyte transition

This study identifies ATP6AP2 and MMP14 as critical for osteoblast-to-osteocyte transition, showing their role in osteocyte maturation, morphology, and bone matrix remodeling.

Osteoblast cell death triggers a pro-osteogenic inflammatory response regulated by reactive oxygen species and glucocorticoid signaling in zebrafish

The paper shows that osteoblast death in zebrafish triggers macrophage recruitment via reactive oxygen species, which is modulated by glucocorticoids and essential for osteoblast repopulation of lesions.

SLC38A2 provides proline to fulfil unique synthetic demands arising during osteoblast differentiation and bone formation.

The paper identifies SLC38A2 as essential for proline supply during osteoblast differentiation and bone formation, showing its role in proline-rich protein synthesis.

Hypertrophic Chondrocytes Serve as a Reservoir for Marrow Associated Skeletal Stem and Progenitor Cells, Osteoblasts, and Adipocytes During Skeletal Development

The paper shows hypertrophic chondrocytes dedifferentiate into marrow-associated stem/progenitor cells that contribute to osteoblasts, adipocytes, and bone marrow establishment during skeletal development.

LGR6 is necessary for attaining peak bone mass and regulates osteogenesis through differential ligand use

This study shows LGR6 is essential for osteoblast proliferation, differentiation, and peak bone mass, with distinct signaling roles for its ligands RSPO2 and MaR1.

Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin

This study identifies Sp7 and its target gene osteocrin as critical for osteocyte dendrite formation and shows their role in human skeletal diseases.

SLC1A5 provides glutamine and asparagine necessary for bone development in mice

This study identifies Slc1a5 as essential for osteoblast differentiation and bone development by facilitating glutamine and asparagine import in mice.

A systematic dissection of human primary osteoblasts in vivo at single-cell resolution

This study identifies three human osteoblast subtypes using scRNA-seq, revealing a novel subtype with unique gene expression and functional roles in bone and hematopoiesis.

Mmp-13 deletion in cells of the mesenchymal lineage increases bone mass, decreases endocortical osteoclast number, and attenuates the cortical bone loss caused by estrogen deficiency in mice

Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells

This study shows Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells toward adipogenesis through C3 and Wnt/β-catenin signaling inhibition.

Osteocyte Transcriptome Mapping Identifies a Molecular Landscape Controlling Skeletal Homeostasis and Susceptibility to Skeletal Disease

The paper maps the osteocyte transcriptome in mice, identifies 1239 genes, and links them to skeletal disease susceptibility in humans.

Epigenetic analysis of Paget's disease of bone identifies differentially methylated loci that predict disease status

This study identifies differentially methylated loci in blood samples of Paget's disease of bone patients, showing their potential as diagnostic markers.

Bone innervation and vascularization regulated by osteoclasts contribute to refractive pain-related behavior in the collagen antibody-induced arthritis model

This study shows osteoclasts contribute to pain in arthritis by affecting bone vascularization and innervation, and inhibitors can reverse this pain.

Ezh2 mediates epigenetic regulation of osteoclastogenesis and bone remodeling in mice

This study shows that Ezh2 deletion in macrophages reduces osteoclastogenesis and increases bone mass in mice, suggesting an epigenetic role in bone remodeling.

Heterogeneity of murine periosteum progenitors involved in fracture healing

This study identifies heterogeneous progenitor cell populations in murine periosteum and their roles in fracture healing.

An activating mutation in Pdgfrb causes skeletal stem cell defects with osteopenia andovergrowth in mice

This study shows that a PDGFRβ mutation causes skeletal stem cell defects leading to osteopenia and overgrowth in mice by altering osteogenic and chondrogenic pathways.

CDK5 Inhibitor Seliciclib Promotes Osteoblastic Differentiation of MSCs and Suppresses the Migration of MG-63 Osteosarcoma Cells

This study shows that Seliciclib promotes osteoblastic differentiation by enhancing F-actin and suppresses osteosarcoma cell migration.

Does methylation of NFATC1 and C-FOS genes are associated with post-menopausal osteoporosis?

The paper investigates the methylation status of NFATC1 and C-FOS genes in pre- and post-menopausal women and finds a significant association between NFATC1 unmethylation and post-menopausal status.

Epigenetic and transcriptional regulation of osteoclastogenesis in the pathogenesis of skeletal diseases: a protocol for a systematic review

This paper outlines a protocol for a systematic review examining the role of epigenetic and transcriptional regulators in osteoclastogenesis and their association with bone disorders.

Activation of mitochondria is an acute Akt-dependent response during osteogenic differentiation

The paper investigates how mitochondrial activation occurs during osteogenic differentiation and identifies Akt-dependent mechanisms and factors like Wnt3a and BMP2 that drive this process.

Genetic Analysis of Osteoblast Activity Identifies Zbtb40 as a Regulator of Osteoblast Activity and Bone Mass

The paper identifies Zbtb40 as a regulator of osteoblast activity and bone mass through genetic analysis in mice, showing reduced BMD and mineralization upon Zbtb40 knockdown.

Bone-targeted lncRNA OGRU alleviates unloading-induced bone loss via miR-320-3p/Hoxa10 axis

This study identifies OGRU, a lncRNA that alleviates unloading-induced bone loss by regulating the miR-320-3p/Hoxa10 axis in osteoblasts.

MiR-146a controls age related bone loss

This study identifies miR-146a as a key regulator of age-related bone loss, showing its role in controlling bone homeostasis through Wnt signaling and its potential as a therapeutic target.

Identification of a Central Neural Circuit that Regulates Anxiety-induced Bone Loss

This study identifies a GABAergic neural circuit from the forebrain to hypothalamus that regulates anxiety-induced bone loss.

Exposure to the RXR agonist SR11237 in early life causes disturbed skeletal morphogenesis in a rat model

This study shows that RXR agonist SR11237 disrupts skeletal development in rats and mice by causing growth plate dysmorphia and impaired long bone growth.