Genomics, phytochemicals, and oxidative stress

Dissecting KEAP1-NRF2 interactions: Structural and functional impact of cancer-associated KEAP1 mutants

This study examines the structural and functional effects of three KEAP1 mutants on NRF2 regulation using biophysical and structural methods, revealing their distinct impacts on protein stability and interaction.

Combined celecoxib and NDGA induces a non-canonical, autophagy-independent redox cell death via p62/KEAP1 in colorectal cancer

This study shows that combining celecoxib and NDGA causes redox-mediated cell death in colorectal cancer cells through the p62/KEAP1 axis, independent of autophagy and apoptotic pathways.

LIN-23 Affects C. elegans Pathogen and Stress Resistance by Modulating SKN-1 Activity

This study identifies LIN-23 as a positive regulator of SKN-1 activity in C. elegans during pathogen exposure, showing it modulates WDR-23 to enhance stress resistance.

NRF2 co-opts the SWI/SNF complex to drive liver cell plasticity

This study shows NRF2 drives liver cell plasticity by co-opting the SWI/SNF complex, and identifies FHD-286 as a therapeutic inhibitor of this process.

Cooperative regulation of NF-E2 related factor 1 protein stability and transcriptional activation by endoplasmic reticulum-associated degradation system mediator, Selenoprotein S/K.

The paper shows SELS and SELK regulate NRF1 stability and transcriptional activity through ER-associated degradation, affecting proteasome subunit expression.

NRF2-Dependent Anti-Inflammatory Activity of Indole via Cell Surface Receptor Signaling in Murine Macrophages

This study shows an indole conjugate inhibits inflammation in macrophages via NRF2-dependent surface receptor signaling.

An aqueous watercress extract with topical anti-inflammatory properties in inflamed human skin

This study develops an aqueous watercress extract and shows it has anti-inflammatory properties in human skin trials and cultured models.

Effects of Gallic Acid on Antioxidant Defense System and Nrf2 Signaling in Mice with Benzene-Induced Toxicity: In Vivo, In Vitro, and Computational Study

This study evaluates gallic acid's protective effects against benzene-induced toxicity in mice, showing improved antioxidant defenses and Nrf2 signaling modulation through in vivo, in vitro, and computational methods.

Early Transcriptomic Signatures of Reductive Stress Cardiomyopathy Reveal Insufficient HIF-1 Signaling

This study identifies early transcriptomic changes in Nrf2-driven reductive stress cardiomyopathy, revealing dysregulation of HIF-1, metabolic, and structural pathways.

Imaging-based temporal dynamics of electrophile-induced NRF2 signaling in liver cells identifies adaptive versus adverse repeated exposure conditions.

This study uses live cell imaging to analyze NRF2 activation dynamics in response to repeated electrophile exposure, showing that recovery periods enable adaptive responses.

Pyrimethamine inhibits mutant NRF2 as a molecular glue

This study shows that pyrimethamine inhibits mutant NRF2 by acting as a molecular glue to restore KEAP1 binding, enhancing therapy sensitivity in ESCC.

Curcumin activates distinct programming of redox metabolism towards differential regulation of gene expression mediated by Nrf1 and Nrf2

This study investigates how curcumin modulates Nrf1 and Nrf2 expression and their roles in redox metabolism and gene regulation in HepG2 cells and xenograft tumors.

Biliverdin Reductase A is a major determinant of neuroprotective Nrf2 signaling

This paper identifies a novel non-enzymatic role for BVRA in modulating Nrf2 signaling, revealing its importance in neuroprotection and potential as a therapeutic target for neurodegenerative diseases.

Wasabi leaf extract changes the expression levels of cytokine related genes in dermal papilla cells, which identified by the whole transcriptome

The paper identifies cytokine-related gene expression changes in dermal papilla cells treated with wasabi leaf extract using next-generation sequencing.

Endogenous CGRP activates NRF2 signaling via non-electrophilic mechanisms

This study shows endogenous CGRP activates NRF2 via non-electrophilic mechanisms, with organ-specific pathways and time-dependent effects on oxidative stress resistance.

Exogenous Thyroxine Increases Cardiac Nrf2-TRX in Insulin Resistant OLETF Rats

This study shows that exogenous thyroxine improves antioxidant defenses and reduces oxidative stress in insulin-resistant OLETF rats.

TEAD1 is a novel regulator of NRF2 and oxidative stress response in cardiomyocytes

This study identifies TEAD1 as a direct regulator of NRF2 and oxidative stress response in cardiomyocytes, showing its critical role in maintaining antioxidant defenses and its downregulation in heart failure.

Pyrimethamine and a potent analogue WCDD115 inhibit NRF2 by suppressing DHFR and one-carbon metabolism

This paper identifies Pyrimethamine and its derivative WCDD115 as potent inhibitors of NRF2 by targeting DHFR and one-carbon metabolism, with WCDD115 showing 22-fold greater efficacy.

Organ-specific electrophile responsivity mappingin live C. elegans

The paper maps organ-specific electrophile responsivity in C. elegans, identifying proteins that respond to reactive metabolites in a tissue-specific manner.

NRF2 pathway activation reverts high-glucose-induced transcriptional memory in endothelial cells

This study shows that transient high glucose exposure induces persistent transcriptional and chromatin changes in endothelial cells, which can be reversed by NRF2 pathway activation.

Nrf2 prevents diabetic cardiomyopathy via antioxidation and normalization of glucose and lipid metabolism in the heart

This study shows that Nrf2 overexpression in cardiomyocytes prevents diabetic cardiomyopathy by reducing oxidative stress and correcting glucose and lipid metabolism.

Nrf2 promotes thyroid development and hormone synthesis.

This study shows that NRF2 regulates thyroglobulin expression in zebrafish and mouse thyroid organoids to manage oxidative stress during thyroid hormone synthesis.

SKN-1 is a metabolic surveillance factor that monitors amino acid catabolism to control stress resistance

This study identifies SKN-1 as a metabolic surveillance factor that responds to amino acid catabolism to influence stress resistance in C. elegans.

Dysfunction of an energy sensor NFE2L1 triggers uncontrollable AMPK signal and glucose metabolism reprogramming

This study shows that NFE2L1 dysfunction leads to AMPK-driven glucose metabolism reprogramming and mitochondrial damage in liver cancer.

PICH, an ATP-dependent chromatin remodeling protein, transcriptionally co-regulates oxidative stress response.

This study shows PICH, an ATP-dependent chromatin remodeler, co-regulates oxidative stress response with Nrf2 by modulating antioxidant gene expression and interacting with H3K27ac.

Function expansion of antitumor transcriptional activator NFE2L1 by the original discovery of its non-transcription factor activity

This study discovers the non-transcription factor activity of NFE2L1 in cytoplasm, revealing its tumor suppressive role through Wnt/β-catenin signaling repression, independent of its transcriptional function.

Bach2 is a potent repressor of Nrf2-mediated antioxidant enzyme expression in dopaminergic neurons

This study identifies Bach2 as a repressor of Nrf2-mediated antioxidant enzyme expression in dopaminergic neurons, explaining limited Nrf2 activity and proposing Bach2 as a drug target for Parkinson's disease.

Basal Role for Nrf2-transgne on transcriptional (mRNA/miRNA) regulation in the mouse myocardium

This study investigates the basal role of excess Nrf2 in regulating mRNA and miRNA interactions in the mouse myocardium using transgenic mice and high-throughput sequencing.