D. Wang

Comammox and Unknown Candidate AOBs Contribute to Nitrite Accumulation in An Integrated A-B stage process that Incorporates Side-stream EBPR (S2EBPR)

The paper demonstrates an integrated wastewater treatment process that achieves nitrite accumulation through comammox and unknown AOBs, revealing their role in short-cut nitrogen removal.

PRMT1 Inhibition Selectively Targets BNC1-Dependent Proliferation, but not Migration in Squamous Cell Carcinoma

This study identifies BNC1-PRMT1 as a transcriptional axis promoting SCC growth, showing PRMT1 inhibition reduces tumor size without affecting migration.

Complex chemical signals dictate Ah receptor activation through the gut-lung axis

The paper shows that urolithin A enhances AHR activity in gut and lung tissues by reducing clearance via CYP1A1/1B1, suggesting a role for dietary substrates in modulating AHR signaling through the gut-lung axis.

A novel order-level lineage of ammonia-oxidizing Thaumarchaeota is widespread in marine and terrestrial environments

The paper identifies a new AOA order, Nitrosomirales, widespread in marine and terrestrial environments, showing metabolic versatility and horizontal gene transfer.

Lumbar endplate microfracture injury induces Modic-like changes, intervertebral disc degeneration and spinal cord sensitization-An In Vivo Rat Model

Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy

The paper shows that PTEFb enables rapid transcriptional reorganization in glioma cells after radiotherapy, enhancing survival, and that inhibiting PTEFb reduces this response and increases cell death.

Single-cell transcriptomic landscape deciphers novel olfactory neuroblastoma subtypes and intratumoral heterogeneity

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

Dalpiciclib Partially Abrogates ER Signaling Activation Induced by Pyrotinib In HER2+HR+ Breast Cancer

The paper investigates how dalpiciclib affects ER signaling activation induced by pyrotinib in HER2+HR+ breast cancer and identifies CALML5 as a risk factor.

FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1

This study shows FAM76B inhibits NF-κB-mediated inflammation by affecting hnRNPA2B1 translocation in vitro and in a TBI mouse model, and identifies its interaction with hnRNPA2B1 in human TBI and neurodegenerative disease tissues.

High Sensitivity Top-down Proteomics Captures Single Muscle Cell Heterogeneity in Large Proteoforms

This study develops a sensitive top-down proteomics method to analyze large proteoforms in single muscle cells, revealing heterogeneity and linking it to muscle fiber types.

Root-associated Fungi in Orchidaceae: Diversity, Phylogeny, Ecology, and Outstanding Questions

This study maps the phylogenetic distribution and ecological lifestyles of root-associated fungi in orchids using a comprehensive DNA dataset, revealing high fungal diversity in orchid mycorrhizal symbiosis.

RecA balances genomic stability and evolution using many successive mismatch tolerant homology tests

The paper models how RecA in E. coli balances genomic stability and evolution by testing homology with increasing stringency, predicting that 50 bp of testing is needed for accurate allelic pairing.

Boosting wheat functional genomics via indexed EMS mutant library of KN9204

The paper generates and indexes an EMS mutant library for KN9204 wheat to enhance functional genomics and genetic manipulation for agronomic traits.

Systematic mining and functional analysis of factors regulating wheat spike development for breeding selection

This study identifies regulators of wheat spike development through multi-omic analysis and GWAS, revealing novel transcription factors that influence spike architecture and flowering time.

Efficient Multi-Label Attribute Classification and Recognition of Microbiological Bacteria Based on Deep Learning and model fine-tuning

This paper proposes a deep learning model for multi-label bacterial classification, showing it is lighter, faster, more accurate, and efficient than existing methods.

Combined Developmental Toxicity Of Cyhalofop-butyl And Quizalofop-p-ethyl On The Zebrafish (Danio rerio) Embryos

This study evaluates the combined developmental toxicity of cyhalofop-butyl and quizalofop-p-ethyl on zebrafish embryos, finding an antagonistic effect and altered gene expression related to apoptosis and cardiac development.

Inclusion Complexation of S-Nitrosoglutathione for Sustained NO Release and Reduced Device Infection

This paper develops a host-guest chemistry strategy using cyclodextrins to stabilize GSNO and control NO release, improving its therapeutic and anti-infective applications.

Correlation analysis between drug resistance and virulence genes of carbapenem-resistant Acinetobacter baumannii In Western Guilin

Control of lipolysis by a population of oxytocinergic sympathetic neurons

This study identifies a population of oxytocinergic sympathetic neurons that regulate adipose tissue lipolysis and metabolic homeostasis in mice and humans.

Bone marrow hemogenic endothelial cells contribute multilineage hematopoietic progenitors in adult mice

The paper identifies a subset of bone marrow endothelial cells in adult mice that generate hematopoietic progenitors and mature blood cells through endothelial-to-hematopoietic transition.

Life-course social disparities in body mass index trajectories across adulthood: cohort study evidence from China Health and Nutrition Survey

This study examines how socioeconomic status across the life course affects BMI trajectories and obesity risk in China using longitudinal data from the China Health and Nutrition Survey.

Genomic and transcriptional profiling stratifies VQ myeloma lines into two clusters with distinct risk signatures and drug responses

The effector recognition by synthetic sensor NLR receptors requires the concerted action of multiple interfaces within and outside the integrated domain

This study shows that synthetic sensor NLR receptors require multiple interfaces within and outside their integrated domain to recognize noncorresponding effectors and activate resistance.

Pink1-mediated mitophagy in the endothelium releases proteins encoded by mitochondrial DNA and activates neutrophil responses

This study identifies endothelial mitophagy as a source of mitochondrial formyl proteins that activate neutrophils and contribute to lung inflammation.

Blocking necroptosis reduces inflammation and tumor incidence in a mouse model of diet-induced hepatocellular carcinoma

Type 17 Follicular Helper T (Tfh17) Cells are Superior for Memory Maintenance

This study shows that Tfh17 cells are more effective than Tfh1 and Tfh2 cells in maintaining memory responses after vaccination.

Synergizing exchangeable fluorophore labels for multi-target STED microscopy

This paper demonstrates 6-target STED microscopy using exchangeable labels, improving multiplexing capabilities and reducing photobleaching in live-cell imaging.

A point mutation in Chl biosynthesis gene Mg-chelatase I subunit influences on leaf color and metabolism in strawberry

This study identifies a point mutation in the CHLI gene of strawberry that affects leaf color and metabolism by reducing chlorophyll and flavonoid levels and altering light sensitivity.

A Long-Circulating Vector for Aptamers Based upon Polyphosphodiester-Backboned Molecular Brushes

This paper develops a long-circulating molecular brush to enhance aptamer stability and bioactivity in vivo.

On-target inhibition of Cryptosporidium parvum by nitazoxanide (NTZ) and paclitaxel (PTX) validated using a novel MDR1-transgenic host cell model and algorithms to quantify on/off-target rates

The paper validates on-target and off-target effects of anti-Cryptosporidium drugs using a novel MDR1-transgenic host cell model and algorithms to quantify drug action contributions.