Tuberculosis Research and Epidemiology

Cure-screening predicts mechanism of post-antibiotic relapse in Tuberculosis

This paper uses a computational model to simulate TB relapse mechanisms, showing that relapse after cure diagnosis is due to non-replicating bacteria reactivating, while unscreened relapse is due to incomplete sterilization.

Monocyte Metabolic Plasticity and Cytokine Production Differentiate Latent TB Infection from Active Disease

This study compares monocyte phenotypes, function, and metabolism in latent TB infection, active TB disease, and healthy controls, finding distinct metabolic and cytokine profiles that differentiate the conditions.

PE/PPE proteins contribute to Mycobacterium tuberculosis drug resistance

This study identifies PE/PPE proteins in Mycobacterium tuberculosis as contributors to drug resistance through genetic association and in vitro experiments.

Lysine specific demethylase 1 (LSD1) regulates host alpha-ketoglutarate levels to modulate lipid peroxidation during Mycobacterium tuberculosis infection

This study shows LSD1 regulates host alpha-ketoglutarate levels, modulating lipid peroxidation and mycobacterial survival during tuberculosis infection.

The mycobacterial ATP burst is a lysis artifact and serves as an assay for drug-induced cell wall damage

This study shows the mycobacterial ATP burst is an experimental artifact caused by cell lysis, not a biological response, and presents it as a tool for screening cell wall-disrupting drugs.

Tyloxapol inhibits ESX-1 secretion in Mycobacterium marinum

This study shows that tyloxapol inhibits ESX-1 secretion in Mycobacterium marinum at low concentrations, affecting its lytic activity and potentially explaining its anti-tuberculosis effects.

The Mycobacterium tuberculosis long-chain fatty acid resistome reveals the universal stress protein TB15.3 as essential for infection

This study identifies Mtb's LCFA resistome and shows TB15.3 as a critical metabolic regulator preventing LCFA toxicity during infection.

In silico structural analysis of EthA substitutions for ranking priority mutations leading to ethionamide resistance in Mycobacterium tuberculosis

The paper identifies priority EthA substitutions associated with ethionamide resistance in Mycobacterium tuberculosis using in silico structural analysis and experimental validation.

Estimating the seroprevalence of tuberculosis (Mycobacterium bovis) infection in a wild deer population in southwest England

This study estimates M. bovis seroprevalence in a wild deer population in southwest England using serological surveys and Bayesian analysis.

A new stress-response pathway in Mycobacterium tuberculosis

This study identifies a new stress-response pathway in Mycobacterium tuberculosis that produces GABA-trehalose under hypoxia and immune stress.

Small RNA ASpks2 Promote Mycobacterium tuberculosis Survival in Macrophages via Targeting Polyketide Synthase 2

The paper identifies a novel small RNA, ASpks2, in Mycobacterium tuberculosis that promotes bacterial survival in macrophages by targeting polyketide synthase 2.

Synaptotagmin 1 and Synaptotagmin 7 promote MR1-mediated presentation of Mycobacterium tuberculosis antigens

This study identifies Synaptotagmin 1 and 7 as facilitators of MR1-mediated antigen presentation of Mycobacterium tuberculosis to MAIT cells.

TB-Bench: A Systematic Benchmark of Machine Learning and Deep Learning Methods for Second-Line TB Drug Resistance Prediction

TB-Bench benchmarks ML and DL models for predicting second-line TB drug resistance using WGS data, finding traditional ML models outperform DL models in internal testing but show comparable performance in external validation.

Title: Multimodal profiling reveals Mycobacterium tuberculosis restricts lung mitochondrial immunometabolism to promote pathogenesis

This study identifies how M. tuberculosis manipulates lung mitochondrial metabolism to promote pathogenesis and reveals a mitochondrial immunometabolic signature associated with protective immunity.

Long-read sequencing of Mycobacterial tuberculosis is comparable to short-read sequencing for antimicrobial resistance prediction and epidemiological studies.

This study compares long-read and short-read sequencing for tuberculosis drug resistance and outbreak analysis, finding they are comparable with minimal differences in key clinical outputs.

Leveraging a synthetic biology approach to enhance BCG-mediated expansion of Vγ9Vδ2 T cells

This paper uses synthetic biology to engineer BCG to produce HMBPP, enhancing Vγ9Vδ2 T cell expansion without feedback inhibition, offering a strategy to improve TB vaccine efficacy.

All-trans retinoic acid recalibrates macrophage transcriptional responses to drug-resistant Mycobacterium tuberculosis through strain-specific immunometabolic reprogramming

This study investigates how all-trans retinoic acid (ATRA) affects macrophage gene expression in response to different drug-resistant Mycobacterium tuberculosis strains, revealing strain-specific transcriptional changes and potential therapeutic targets.

Lineage 2-Beijing Mycobacterium tuberculosis strains suppress BCG-trained innate immunity early after infection

This study shows L2-B Mycobacterium tuberculosis strains evade BCG vaccine-induced immunity by suppressing macrophage activation and trained innate immunity.

A structural Merton jump-diffusion framework for survival analysis: Modeling biological solvency and distance-to-death(DtD) in tuberculosis

This paper applies a financial engineering model to TB survival analysis, identifying BMI thresholds and HIV's impact on mortality risk using a large Cameroonian cohort.

The global phylogeography of rapidly expanding multidrug resistant Ural lineage 4.2 Mycobacterium tuberculosis

The paper identifies a rapidly expanding multidrug-resistant M. tuberculosis clade originating from Russia and circulating in Moldova, posing a threat to MDR-TB control.

Phosphoserine aminotransferase SerC is a central metabolic checkpoint and druggable vulnerability in Mycobacterium tuberculosis

This study identifies SerC as a critical metabolic enzyme in Mtb, showing its essential role in survival and revealing it as a potential drug target for TB therapy.

Pathotypr: harmonised MTBC lineage assignment and resistance-associated variant detection for genomic surveillance

Pathotypr is a tool for MTBC lineage assignment and resistance variant detection, achieving high accuracy and speed for genomic surveillance.

A critical signaling role for diacylglycerol in phagocytosis of M. tuberculosis

This study identifies diacylglycerol (DAG) as critical for phagocytosis of M. tuberculosis, showing that DAG disruption reduces uptake without affecting receptor trafficking or cargo binding.

Rv1985c-Driven Transcriptional Network Rewiring Underlies Lineage-Specific Phenotypes in Mycobacterium tuberculosis

This study identifies lineage-specific transcriptional network rewiring in Mtb by analyzing proteomic and transcriptomic data from L1 and L2 strains, revealing key regulators like Rv1985c that drive phenotypic differences.

Functional divergence of regulatory and conventional bovine neutrophils following Mycobacterium bovis infection

This study compares the functional responses of regulatory and conventional bovine neutrophils to Mycobacterium bovis infection, revealing distinct transcriptional, metabolic, and phagocytic profiles.

Structural basis of Mycobacterium Fluoroquinolone Resistance Protein D (MfpD), a versatile pathogeny protein from the mfp conservon of Mycobacterium tuberculosis

This study defines the structural basis of MfpD function using phylogenetic, structural, and biophysical approaches, revealing its role in promoting GTP hydrolysis by MfpB through a noncanonical mechanism.

Loss of Mycobacterium marinum ESX-1 genes increase transcription of ESX-6 genes

The paper shows that loss of ESX-1 genes in M. marinum strain 1218S increases transcription of ESX-6 and LOS genes, affecting colony morphology and biofilm formation.

Predicting Isoniazid Resistance in Mycobacterium tuberculosis Complex in New York State using Whole Genome Sequencing

This study uses whole genome sequencing to predict isoniazid resistance in Mycobacterium tuberculosis complex strains, showing high accuracy and demonstrating its utility in clinical settings.

The balance between antiviral and antibacterial responses during M. tuberculosis infection is regulated by the ubiquitin ligase CBL

This study identifies CBL as a regulator of antiviral and antibacterial responses during M. tuberculosis infection by suppressing antiviral effector genes and modulating ubiquitin-mediated signaling.

Sec and Tat mediated secretion safeguards Mycobacterium tuberculosis membrane homeostasis

This study identifies SecA1 and TatA as critical for Mycobacterium tuberculosis membrane integrity through multi-omics and functional genetics analyses.