Sperm and Testicular Function

A sperm-enriched 5'fragment of tRNA-Valine regulates preimplantation embryonic transcriptome and development

This study identifies a sperm-enriched tRFValCAC that regulates early embryonic mRNA splicing and preimplantation development through interactions with hnRNPAB.

A novel CHD4-CTCF regulatory axis drives key developmental programs and transitions in male germ cells.

This study identifies a CHD4-CTCF regulatory axis that controls key developmental programs and transitions in male germ cells by regulating chromatin structure and gene expression.

Sperm meet the elevated energy demands to attain fertilization competence by increasing flux through aldolase

This study identifies how sperm increase metabolic flux through aldolase to meet energy demands during capacitation, revealing conserved metabolic regulation mechanisms in mammalian cells.

Lipid Signature of Motile Human Sperm: Characterization of Sphingomyelin, Ceramide and Phospholipids with a Focus on Very Long Polyunsaturated Fatty Acid

This study characterizes the lipid composition of motile human sperm, highlighting the abundance of very long polyunsaturated fatty acids in sphingomyelin and ceramide.

Assessment of the Effects of Muira Puama Root Extract on Biochemical Indices, and Testicular Histomorphology in Cyclophosphamide-treated Rats

This study evaluates Muira puama extract's protective effects against cyclophosphamide-induced testicular damage in rats, showing improved antioxidant status and reduced histopathological damage.

The functional maturation of mouse spermatozoa is underpinned by global remodeling of the cellular phosphoproteome

This study identifies extensive phosphoproteomic remodeling in mouse sperm during maturation and capacitation, revealing key kinases and their roles in fertility.

MAP7-driven microtubule remodeling builds the Sertoli apical domain that supports timely meiotic progression

This study identifies MAP7 as a key regulator of microtubule remodeling in Sertoli cells, essential for apical domain formation and timely meiotic progression in mouse testes.

A spermatogonial perspective on the expansion of the mammalian brain

The paper investigates the molecular overlap between spermatogonia and neural programs, showing enrichment of brain-expansion genes in spermatogonia across mammals.

TSSK homologue regulates the expression of protamine and mosquito testes specific genes in Anopheles stephensi

This study identifies tssk homologues in Anopheles stephensi and Aedes aegypti, showing their male-specific expression and role in regulating protamine and mts gene expression through NAP interaction.

Semenogelin-1 Inhibition of Mouse Sperm Hyperactivation Reveals Two Functional Domains Modulating CatSper Channel

This study identifies two functional domains in SEMG1 that inhibit sperm hyperactivation by suppressing CatSper channel activity, providing insights for non-hormonal male contraception.

Early development of male germ cell clones shapes their reproductive success

The paper traces individual PGC clones in mice to show early stochastic bottlenecks shape clonal contributions and reproductive success.

A systematic review of the factors affecting sperm binding and release from the oviduct using in vitro experimental animal models

This review systematically assesses non-steroid hormone factors affecting sperm binding and release from the oviduct in animal models to improve IVF protocols and infertility treatments.

The Caenorhabditis elegans spe-21 gene that encodes a palmitoyltransferase is necessary for spermiogenesis.

This study identifies spe-21 as a palmitoyltransferase essential for spermatid activation and spermatozoon formation in C. elegans.

Quantitative phosphoproteomic analysis of testes from Iqcn-deficient mice highlights the significance of calmodulin signaling in spermiogenesis

This study identifies CaMBPs regulated by IQCN-CaM interaction through phosphoproteomic analysis of Iqcn-deficient mice testes, showing their role in spermiogenesis and sperm motility.

Cnot3 is required for male germ cell development and spermatogonial stem cell maintenance

This study shows that CNOT3 is essential for maintaining spermatogonial stem cells in mice by repressing differentiation factors and regulating the redox pathway.

ISWI chromatin remodeler SMARCA5 is essential for meiotic gene expression and male fertility in mammals

This study shows that SMARCA5 is essential for meiotic gene expression and male fertility by regulating chromatin accessibility during spermatogenesis.

The SMARCA5-DMRT1 Pioneer Complex Establishes Epigenetic Priming to Direct Male Germline Development

This study shows that SMARCA5 and DMRT1 form a pioneer complex that establishes epigenetic priming necessary for male germline differentiation in response to retinoic acid.

DNAH14 deficiency impairs sperm motility by reducing flagellar beat amplitude

This study identifies DNAH14 as critical for sperm motility by reducing flagellar beat amplitude, and suggests a potential therapeutic approach through increased sperm concentration in IVF.

Meioc-Piwil1 complexes regulate rRNA transcription for differentiation of spermatogonial stem cells

The paper shows that Meioc-Piwil1 complexes regulate rRNA transcription in zebrafish spermatogonial stem cells, preventing Piwil1 from localizing to nucleoli and promoting differentiation.

Tailoring a glycerol-free cryopreservation protocol with anti-freeze (glycol)proteins for commercial and native breeds of chicken

This study evaluates the effects of antifreeze proteins on chicken semen cryopreservation, finding mixed results in post-thaw viability and fertility.

Two Spag6 genes control sperm formation and male fertility in mice

This study identifies two Spag6 genes in mice and shows their distinct roles in sperm formation and male fertility, with SPAG6 being critical for fertility despite normal phenotype in single knockout mice.

Protamine sequence determines species-specific nuclear shape and histone retention

The paper shows that species-specific PRM1 cysteine residues determine nuclear shape and histone retention in sperm by analyzing mutant mice.

NEDD4 promotes Sertoli cell proliferation and adult Leydig cell differentiation in the murine testis

This study identifies NEDD4's role in promoting Sertoli cell proliferation and adult Leydig cell differentiation in murine testis development through PI3K-AKT signaling and steroidogenesis.

Bacterial Vaginosis Toxins Impair Sperm Capacitation and Fertilization

This study shows that bacterial vaginosis toxins impair sperm capacitation and fertilization by disrupting calcium homeostasis and motility.

The dynamics of ciliogenesis in prepubertal mouse meiosis reveal new clues about testicular maturation during puberty

This study characterizes the dynamics of primary cilia in prepubertal mouse spermatocytes, revealing their emergence after the first meiotic wave and potential roles in DNA repair and spermatogenesis.

Uncovering Symbolic Convergence in Human Sperm Motility: A Data-Driven Analysis of Monotonic Trajectory Clusters

The paper uses symbolic encoding to identify a consistent trajectory cluster in sperm motility data, characterized by low entropy and high motif dominance.

Phase-Space Dynamics Reveal Structured and Chaotic Motility in Human Sperm via DTW Clustering

The paper uses DTW clustering to identify structured and chaotic motility phenotypes in human sperm from the VISEM dataset, revealing distinct dynamic patterns and fatigue characteristics.

Meiotic prophase I disruption as a strategy for non-hormonal male contraception using small-molecule inhibitor JQ1

This study shows that JQ1 disrupts meiotic prophase I in male mice, leading to reversible infertility, suggesting a potential non-hormonal contraceptive strategy.

Transcription factor NFYA directs male meiotic entry by facilitating accessible chromatin at meiotic promoters in mice

The paper identifies NFYA as a factor that promotes accessible chromatin at meiotic gene promoters in pre-meiotic germ cells, enabling timely meiotic entry in mice.

Age-related declines in niche self-renewal factors controls testis aging and spermatogonial stem cell competition through Hairless, Imp, and Chinmo

The paper identifies a regulatory axis involving BMPs, Hairless, Imp, and Chinmo that drives testis aging and spermatogonial stem cell competition in Drosophila.