Glaucoma and retinal disorders

Circadian IOP rhythm in rats is driven by neural signals from the brain

This study shows that the circadian intraocular pressure (IOP) rhythm in rats is driven by sympathetic efferents from the superior cervical ganglion, not local oscillators or humoral signals.

Piezo1 Triggers an Angiopoietin-2-Integrin Signaling Loop in Schlemm's Canal to Regulate Intraocular Pressure

The paper identifies a PIEZO1-ANGPT2-ITGA9 signaling pathway in Schlemm's canal endothelium that regulates intraocular pressure and glaucoma.

Additive framework of hormonal waves explains species and age differences in circadian intraocular pressure rhythm

The paper develops a mathematical framework explaining circadian intraocular pressure (IOP) rhythms through the additive interaction of glucocorticoid and norepinephrine signals, showing it accounts for species differences and age-related changes.

OPTN protects retinal ganglion cells and ameliorates neuroinflammation in optic neuropathies

This study shows that OPTN dysfunction leads to neuroinflammation and RGC death in glaucoma, independent of IOP, and identifies OPTN-NPY signaling as a potential therapeutic target.

Endophenotype-Informed Polygenic Risk Stratification for Primary Open-Angle Glaucoma in individuals of African Ancestry

This paper develops endophenotype-informed polygenic risk scores for POAG in African ancestry individuals, showing improved clinical interpretability and risk stratification compared to aggregate scores.

Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-retinal barrier integrity causing neurodegeneration.

Inferring systemic metabolic and oxidative stress susceptibility in normal-tension glaucoma through targeted skin fibroblast analysis

The paper assesses metabolic and oxidative stress in NTG by analyzing skin fibroblasts, finding no significant differences compared to controls.

Interdependent regulation of trabecular meshwork cell physiology and intraocular pressure by KALRN and TMCO1

This study identifies KALRN and TMCO1 as interdependent regulators of trabecular meshwork homeostasis and intraocular pressure, linking ER and calcium homeostasis to glaucoma pathogenesis.

Modeling human retinal ganglion cell axonal outgrowth, development, and pathology using pluripotent stem cell-based microfluidic platforms

This study uses microfluidic platforms to model human retinal ganglion cell compartmentalization, showing axonal deficits in disease and astrocyte reactivity-induced neurodegeneration.

Evaluating Flavoprotein Fluorescence Imaging as a Biomarker of Early Retinal Ganglion Cell Mitochondrial Stress

This study evaluates flavoprotein fluorescence (FPF) as a biomarker for early retinal ganglion cell mitochondrial stress in vitro and in vivo, finding it sensitive in vitro but limited in vivo.

Leveraging single-cell transcriptomics of developing rat ocular outflow tissues to prioritize congenital glaucoma candidate genes

This study uses single-cell RNA sequencing of developing rat ocular tissues to identify candidate genes for congenital glaucoma.

Single-Cell Characterization of Anterior Segment Development: Cell Types, Pathways, and Signals Driving Formation of the Trabecular Meshwork and Schlemm's Canal

The paper uses single-cell transcriptomics to characterize anterior segment development, identifying cell types, pathways, and signaling networks in trabecular meshwork and Schlemm's canal formation.

Corticosteroids elevate intraocular pressure through suppression of TREK-1 signaling

This study shows corticosteroids increase intraocular pressure by suppressing TREK-1 channels in trabecular meshwork cells, leading to ocular hypertension, which can be counteracted by TREK-1 agonists.

Glaucoma-associated Optineurin mutations increase transmitophagy in a vertebrate optic nerve

The paper investigates how glaucoma-associated Optineurin mutations affect transmitophagy in Xenopus laevis optic nerves, finding increased mitochondrial shedding and degradation by astrocytes.

Hsa-MiR-483 -3p Regulates the Extracellular Matrix Proteins via TGFbeta2/SMAD4 Signaling in the Glucocorticoid-responsive Human Trabecular Meshwork Cells

This study shows that miR-483-3p reduces ECM production via SMAD4/TGFβ2 signaling in glucocorticoid-responsive HTM cells, suggesting therapeutic potential for steroid-induced glaucoma.

GPX4 Promotes Optic Nerve Regeneration and RGC Neuroprotection

This study shows that GPX4 overexpression in RGCs promotes optic nerve regeneration and neuroprotection in glaucoma models.

Whole-genome sequencing study of 488,888 individuals identifies rare variants and genes associated with glaucoma

This study uses whole-genome sequencing of 488,888 individuals to identify rare genetic variants and novel genes associated with glaucoma, including potential drug targets.

Iris Crypts Could Reduce the Chance of Angle Closure: A Computational Biomechanics Study Derived from Clinical and Human Iris Data

This study uses computational biomechanics to show that iris crypts can prevent angle closure by maintaining anterior chamber angles above 20.36 degrees during pupil changes.

Differential retinal ganglion cell resilience to optic nerve injury across vertebrate species

The paper compares retinal ganglion cell resilience to optic nerve injury across mice, zebrafish, and killifish, revealing species-specific differences in RGC density and injury response.

TLR4 deficiency does not alter glaucomatous progression in a mouse model of chronic glaucoma

This study investigates the role of TLR4 in chronic glaucoma using a mouse model and finds no significant effect on glaucomatous progression.

Restoring AIBP expression in the retina provides neuroprotection in glaucoma

This study shows that restoring AIBP expression in glaucomatous retinas protects retinal ganglion cells and reduces neuroinflammation in mouse models.

Impact of anatomic variability and other vascular factors on lamina cribrosa hypoxia

The paper models LC oxygenation under varying vascular and anatomical conditions, finding vessel radius and anatomical variation are most influential.

Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma

The paper identifies a metabolomic signature of resilience to glaucoma in high-risk individuals and validates pyruvate's protective role in a mouse model.

Survival of Transplanted Retinal Ganglion Cell in Human Donor Eyes under Elevated Pressure

The paper investigates RGC survival under elevated vs. normal IOP using hiPSC-derived RGCs in human donor eyes, finding better survival at normal IOP.

Mitochondrial and Microtubule Defects in Exfoliation Glaucoma

This study identifies mitochondrial and microtubule defects in XFG patient-derived fibroblasts and suggests mitophagy inducers as potential therapeutics.

Integrating Glaucoma Endophenotypes Improves Polygenic Risk Prediction for Primary Open-Angle Glaucoma Across Ancestries

This paper develops a multi-trait polygenic risk score framework to improve POAG prediction across ancestries by integrating glaucoma endophenotypes.

Optic nerve crush does not induce retinal ganglion cell loss in the contralateral eye.

The paper quantifies retinal ganglion cell (RGC) numbers in the contralateral eye after optic nerve crush and finds no RGC loss, contradicting previous reports.

Nocturnal intraocular pressure rise is regulated by norepinephrine via RHOB

This study identifies RHOB as a mediator of norepinephrine-induced intraocular pressure elevation in the trabecular meshwork, suggesting it as a potential therapeutic target for glaucoma.

The heterogeneous distribution of glial cell marker proteins in the myelinated region of the normal rat optic nerve

This study examines the distribution of glial cell markers in the rat optic nerve, finding heterogeneous expression patterns that suggest physiological stress in the distal-most region.

Monitoring mutant myocilin secretion and localization in trabecular meshwork cell cultures using a protein complementation-based luminescence assay

This paper introduces a luminescence assay to detect myocilin secretion defects in trabecular meshwork cells and confirms secretion issues for several mutant variants.