Glaucoma and retinal disorders

The 5-HT1A receptor antagonist WAY-100635 maleate reprograms metabolism to promote RGC differentiation and regeneration in retino-visual centers

This study identifies WAY-100635 as a neuroprotectant that reprograms metabolism to promote RGC differentiation and regeneration in glaucoma models.

rAAV prostaglandin-based gene therapy lowers intraocular pressure and preserves optic nerve health in glaucomatous DBA/2J mice

Loss of microglia reduces NGF signaling and retinal ganglion cell survival

This study shows that microglia are essential for NGF/TrkA signaling and neuroprotection in the retina, as their depletion leads to reduced NGF signaling and retinal ganglion cell loss.

Visual Function Correlates More Strongly with Glial Coverage than Axon Count Across Multiple Mouse Strains

Macrophage Migration Inhibitory Factor (MIF)-CD74 Signaling Pathway Mediates Trabecular Meshwork Dysfunction in Glaucoma.

This study identifies MIF-CD74 signaling as a regulator of trabecular meshwork dysfunction in glaucoma, showing its role in suppressing Blimp-1 and promoting ECM remodeling and cytoskeletal changes.

Chromatin dynamics identifies 78 genes at loci associated with elevated intraocular pressure and primary open-angle glaucoma

The paper identifies 78 genes associated with elevated intraocular pressure and primary open-angle glaucoma by analyzing chromatin dynamics and integrating GWAS variants with 3D chromatin landscapes.

Compensatory responses to glaucoma pathology in the dorsolateral geniculate nucleus

This study investigates compensatory plasticity in the dorsolateral geniculate nucleus of glaucomatous mice, finding increased intrinsic excitability and reduced inhibition in relay neurons despite diminished retinal input.

Lipidomic Analysis Reveals Drug-Induced Lipoxins in Glaucoma Treatment

The paper identifies drug-induced lipoxins in glaucoma treatment, showing latanoprost increases lipoxin A4, which reduces inflammation and lowers intraocular pressure.

Studies of mice with a large deletion of the ARPKD-associated Pkhd1 locus likely explain its GWAS association with glaucoma in humans

The paper shows that a Pkhd1 deletion in mice causes glaucoma by disrupting Tfap2b expression, linking PKHD1 SNPs to human glaucoma.

Uncovering the Genetic Architecture of Optic Nerve Integrity Estimates through Genome-wide Association Study Meta-analyses

This study performs genome-wide association meta-analyses on optic nerve structure biomarkers, identifying novel loci and potential drug targets independent of intraocular pressure.

Cell-Intrinsic Vulnerability and Immune Activation Cooperate to Drive Degeneration in a Mitochondrial Complex I Deficiency Model of Optic Neuropathy

This study investigates how mitochondrial dysfunction and immune activation contribute to retinal ganglion cell degeneration in optic neuropathy using transgenic models.

IL1A enhances TNF-induced retinal ganglion cell death

This study shows that IL1A enhances TNF-induced retinal ganglion cell death in a SARM1-dependent manner after combined insult.

Lipoxin B4 Mitigates TRPV4-Activated Muller Cell Gliosis During Ocular Hypertension

This study shows that Muller glia produce Lipoxin B4, which suppresses TRPV4-induced gliosis and neuroinflammation in ocular hypertension.

Pharmacological Depletion of Retinal Mononuclear Phagocytes is Neuroprotective in a Mouse Model of Mitochondrial Optic Neuropathy

This study shows that pharmacological depletion of retinal mononuclear phagocytes with pexidartinib, combined with hypoxia, completely protects retinal ganglion cells in a mouse model of mitochondrial optic neuropathy.

The Mitochondria-Targeted Peptide HDAP2 Reduces Mitochondrial Loss and Retinal Ganglion Cell Degeneration After Optic Nerve Injury

Loss of Cathepsin K impairs collagen biogenesis and enhances actin polymerization in trabecular meshwork

This study shows that loss of Cathepsin K disrupts collagen biogenesis, ECM homeostasis, and actin polymerization in trabecular meshwork cells, potentially affecting aqueous humor outflow and IOP regulation.

Step change in glaucoma polygenic risk score performance enables clinical utility and disease prediction across all major ancestries

This paper develops a polygenic risk score for glaucoma with improved performance across major ancestries, enabling earlier detection and targeted treatment of high-risk individuals.

Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment

The paper identifies mitochondrial dysfunction in a glaucoma model using single-cell analysis and shows that vitamin B3 treatment protects against IOP elevation.

Sortilin deficiency alters baseline retinal homeostasis and injury-induced signaling without affecting optic nerve crush-induced neurodegeneration

This study investigates sortilin's role in retinal homeostasis and injury response, finding it does not prevent neurodegeneration but affects glial activation and neurotrophin dynamics.

Time-dependent Glucocorticoid-Induced Transcriptomic Changes in Human Trabecular Meshwork and Schlemm's Canal

This study identifies glucocorticoid-induced transcriptomic changes in human trabecular meshwork and Schlemm's canal cells using RNA-seq, finding genes associated with glaucoma and intraocular pressure.

Retinal nerve fibre layer thickness reflects characteristics of brain grey and white matter

The paper investigates associations between retinal nerve fibre layer thickness and brain grey/white matter structure, finding some links but not supporting cardiovascular risk factor associations.

Vitreous Inflammation as an Early Indicator of Retinal Ganglion Cell Loss Following Acute Optic Nerve Injury in Mice

The paper identifies vitreous hyperreflective foci (VHRFs) as an early inflammatory indicator of retinal ganglion cell loss following optic nerve injury in mice and shows IL-1 signaling inhibition reduces VHRFs and delays cell loss.

Mitochondrial-Targeted HDAP2 Preserves Retinal Ganglion Cells and Increases Pressure Tolerance in DBA/2J Mice

Mechanistic insights into glucocorticoid-induced ocular hypertension using differences in mouse strain responsiveness

The paper identifies biomarkers and molecular pathways associated with glucocorticoid-induced ocular hypertension by comparing genetically distinct mouse strains.

MKK4 and MKK7 control degeneration of retinal ganglion cell somas and axons after glaucoma-relevant injury.

This study shows MKK4 and MKK7 drive RGC soma and axon degeneration after glaucoma injury, while DDIT3/JUN only prevent soma loss but not axon degeneration.

TGF-beta/OPTN/FOXC1/miR-200 axis regulates intraocular pressure dynamics in trabecular meshwork cells

This study identifies a regulatory axis involving TGF-beta2, OPTN, FOXC1, and miR-200 that modulates intraocular pressure by affecting extracellular matrix and circadian rhythms in trabecular meshwork cells.

AKAP1 regulates mitochondrial and synaptic homeostasis to enable neuroprotection and repair in retinal ganglion cell degeneration

The paper identifies AKAP1 as a critical regulator of mitochondrial and synaptic homeostasis in glaucoma, showing its role in neuroprotection and axon regeneration through gene therapy in mouse models.

Intracameral Puncture Lowers Intraocular Pressure and Triggers an Immune Response in the Conventional Outflow Tract

Assessment of Visual Function in Mice Using Light/Dark Box and Multi-Feature Machine Learning

This paper improves visual function assessment in mice by using multi-feature machine learning, showing better classification performance than single-metric methods.

Dynamic Retinal Pathology in Glaucoma Progression Revealed by High-Resolution Functional Imaging in Vivo

This study uses high-resolution in vivo imaging to track dynamic retinal changes in glaucoma progression across different phenotypes.