Muscle Physiology and Disorders

Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture

This study shows that culturing muscle fibers in a 3D hydrogel improves viability and preserves contractile function compared to 2D culture.

Skeletal muscle fibre type determines mitochondrial and metabolic responses to hypoxia and pulmonary inflammation.

This study examines how chronic hypoxia and pulmonary inflammation affect mitochondrial function and fibre type composition in oxidative and glycolytic skeletal muscles of rats, revealing distinct responses between muscle types.

Glutamine-Dependent Slc25a39-Nrf2 Axis Couples Mitochondrial Dynamics with Metabolic Reprogramming to Establish Myogenic Commitment

Mesenchymal Stem Cell-Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

The paper constructs a comprehensive FAP interactome in skeletal muscle using single-cell RNA sequencing and computational analysis, identifying novel signaling pathways and validating their roles in homeostasis and regeneration.

Spatiotemporal analysis of dystrophin expression during muscle repair

This study investigates dystrophin mRNA and protein expression dynamics during muscle repair, revealing post-transcriptional control mechanisms and suggesting degradation as a therapeutic target.

Age-dependent Dysferlin Accumulation in Macrophages Promotes STAT1 Activation via Calcium Influx, Impairing Myogenesis

This study shows that DYSF in macrophages promotes STAT1 activation via calcium influx, impairing myogenesis and contributing to muscle atrophy with age.

Leveraging AI for facioscapulohumeral muscular dystrophy prediction and omics biomarker identification

This study uses machine learning to predict FSHD using multi-omics data and identifies key biomarkers, showing improved accuracy with limited samples.

Activin receptor type IIA/B blockade increases muscle mass and strength, but compromises glycemic control in mice

This study shows that blocking ActRIIA/IIB increases muscle mass and strength in mice but causes glucose intolerance and reduced voluntary activity.

The Integrated Stress Response Pathway Improves Aged Murine Muscle Stem Cell Activation and in vivo Regeneration.

This study identifies the Integrated Stress Response (ISR) pathway as a regulator of aged muscle stem cell activation and regeneration, showing pharmacological ISR activation improves their function and muscle repair.

Muscle regeneration can be rescued in a telomerase deficient zebrafish model of ageing by MMP inhibition

This study shows MMP inhibition rescues muscle regeneration in telomerase-deficient zebrafish by improving muscle stem cell migration and function.

Site-1 Protease is a negative regulator of sarcolipin promoter activity

This study shows that Site-1 Protease (S1P) negatively regulates sarcolipin expression by inhibiting its promoter activity through ATF6 and CREB binding.

The multimodal transcriptional response of denervated skeletal muscle involves alterations in cholesterol homeostasis impacting muscle size

This study identifies a multimodal transcriptional response in denervated skeletal muscle, revealing altered cholesterol homeostasis and its impact on myofiber size.

Muscle-specific increased expression of JAG1 improves skeletal muscle phenotype in dystrophin-deficient mice.

This study shows that increasing JAG1 expression in dystrophin-deficient mice improves muscle size, strength, and myofiber number.

Duchenne muscular dystrophy is associated with defective membrane repair and dysregulation of annexin-A1/A2 in skeletal muscle

This study identifies defective membrane repair and dysregulated annexin-A1/A2 expression in Duchenne muscular dystrophy, linking extracellular ANXA2 accumulation to disease severity.

Mechanical Loading Induces the Longitudinal Growth of Muscle Fibers via an mTORC1-Independent Mechanism

This study shows mechanical loading induces muscle fiber growth through two mechanisms: mTORC1-dependent radial growth and mTORC1-independent longitudinal sarcomere addition.

A Novel Mouse Model for LAMA2-Related Muscular Dystrophy: Analysis of Molecular Pathogenesis and Clinical Phenotype

This study presents a Lama2 knockout mouse model for LAMA2-related muscular dystrophy, analyzing its phenotype, neuropathology, and transcriptomics data to elucidate molecular pathogenesis.

Deconvoluting fiber type proportions from human skeletal muscle transcriptomics and proteomics data using FibeRtypeR

This paper introduces FibeRtypeR, a tool to estimate muscle fiber type proportions from bulk transcriptomics and proteomics data using single-fiber reference profiles.

Improvement of Spontaneous Locomotor Activity in a Murine Model of Duchenne Muscular Dystrophy by N-Acetylglucosamine Alone and in Combination with Prednisolone

This study shows that oral N-acetylglucosamine improves spontaneous locomotor activity in mdx mice, with combined treatment enhancing effects compared to prednisolone alone.

DAB2 as a biomarker and mechanistic link between lipid dysregulation and disease progression in LGMD R2

Antxr2-mediated fine-tuning of Collagen VI ensures skeletal muscle function

This study shows that ANTXR2 regulates COL6 turnover in skeletal muscle, and its deficiency leads to ECM stiffening and muscle dysfunction.

Defining a Muscle Stem Cell matrisome signature: from transcriptome data to extracellular matrix niche topology.

This study identifies matrisome signatures in quiescent and activated muscle stem cells using transcriptomic data, linking ECM gene expression to niche function and muscle repair.

Distribution of myogenic stem cell activator, hepatocyte growth factor, in skeletal muscle extracellular matrix and effect of short-term disuse and reloading

This study examines HGF distribution in different muscle fiber types and its nitration during disuse and reloading, finding higher HGF in type IIa/x fibers and increased nitroHGF in disuse.

Endothelial Piezo1 regulates muscle AKT abundance and mechanically induced muscle hypertrophy

This study shows endothelial Piezo1 promotes mechanical overload-induced muscle hypertrophy by regulating AKT abundance, but not muscle regeneration.

Pancreatic Cancer Induces Population-Specific Switching of Myosin Isoforms and Discrete Activation of Cachexia Genes in Skeletal Muscle Myocytes

This study identifies population-specific transcriptional changes in skeletal muscle myonuclei during pancreatic cancer cachexia, revealing distinct gene activation patterns rather than uniform upregulation of cachexia mediators.

Rejuvenation-Responsive and Senolytic-Sensitive Muscle Stem Cells Unveiled by CD200 and CD63 in Geriatric Muscle

The paper identifies a new subpopulation of aged muscle stem cells (GERI-MuSCs) that are senolytic-sensitive and rejuvenation-responsive, characterized by CD200 and CD63 markers.

The influence of power-training and aging on endomysium content and fiber cross-sectional area in the human soleus muscle

This study examines how power-training and aging affect endomysium content and fiber cross-sectional area in human soleus muscle, finding no significant changes in endomysium but increased fiber area with training and aging.

Early lineage segregation of primary myotubes from secondary myotubes and adult muscle stem cells.

The paper tracks progenitor populations in avian embryos to reveal distinct lineages of primary and secondary myotubes and their relationship to adult muscle stem cells.

Klotho deficiency promotes skeletal muscle weakness and is associated with impaired motor unit connectivity

This study shows Klotho deficiency causes skeletal muscle weakness and impaired motor unit connectivity by altering neuromuscular junction structure and function.

Chemogenetic Mitochondrial H2O2 Generation Triggers Dose-Dependent Skeletal Muscle Wasting Signatures

This study uses chemogenetics to induce mitochondrial H2O2 in skeletal muscle and shows it causes dose-dependent atrophy without structural damage.

Elucidating cancer cachexia-mediated aberrant cardiac wasting signaling in human iPSC-derived cardiac muscle

This study investigates cachexia-induced cardiac wasting using human iPSC-derived cardiac muscle, identifying the Atrogin-1/Calcineurin A/NFAT signaling pathway as a key driver of cardiac atrophy and functional impairments.