Folate and B Vitamins Research

The role of folate receptor α in the partial rejuvenation of dentate gyrus cells. Improvement of cognitive function in elderly mice

This study shows that folate improves cognitive function in elderly mice by partially rejuvenating dentate gyrus cells through FR activation and increased expression of juvenile genes.

Vitamin B12 status and folic acid supplementation influence mitochondrial heteroplasmy levels in mice as they age.

The paper investigates how vitamin B12 and folic acid affect mitochondrial DNA heteroplasmy in mice and suggests potential sex-specific effects in humans.

Epigenetic regulation by TET1 in gene-environmental interactions influencing susceptibility to congenital malformations

This study identifies TET1 as a key mediator of gene-environment interactions in congenital malformations, showing how maternal folate status and genetic background influence DNA methylation and NTD susceptibility.

Folate depletion induces erythroid differentiation through perturbation of de novo purine synthesis

This study shows folate depletion induces erythroid differentiation by disrupting purine synthesis, with effects mimicked by SHIN1 inhibition and rescued by purine precursor supplementation.

Late-life dietary folate restriction reduces biosynthetic processes without compromising healthspan in mice

This study shows that reducing folate intake in aged mice decreases biosynthetic processes but does not compromise healthspan, suggesting age-dependent benefits of folate restriction.

Folate depletion alters mouse trophoblast stem cell regulation in vitro

This study shows that folate depletion in culture medium alters mouse trophoblast stem cell differentiation and endoreduplication.

Zebrafish model of tcn2 deletion reveals new molecular insights into the role of vitamin B12 in embryonic development

This study uses zebrafish tcn2 knockout to investigate B12's role in embryonic development, finding that B12 supplementation partially rescues developmental defects and alters gene expression in key pathways.

Non-canonical function of folate/folate receptor 1 during neural tube formation

This study identifies a non-canonical role of folate and FOLR1 in neural tube formation through regulation of CD2AP and Ca2+ signaling, distinct from its metabolic function.

Maternal dietary deficiencies in one-carbon metabolism during early neurodevelopment result in larger damage volume, re-duced neurodegeneration and neuroinflammation and changes in choline metabolites after ischemic stroke in middle-aged offspring

This study examines how maternal dietary deficiencies in one-carbon metabolism affect ischemic stroke outcomes in middle-aged offspring, finding reduced neurodegeneration and neuroinflammation but no impact on motor function.

Maternal dietary deficiencies in folates or choline during pregnancy and lactation worsen stroke outcome in 3-month-old male and female mouse offspring

The 677C>T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice

This study creates a mouse model with the MTHFR 677C>T variant and shows it causes cerebrovascular deficits, supporting its use in preclinical research on vascular dementia.

The impact of maternal dietary folic acid or choline deficiencies on cerebral blood flow, cardiac, aortic, and coronary function in young and middle-aged female mouse offspring following ischemic stroke

This study examines how maternal deficiencies in folic acid or choline affect cerebral and peripheral blood flow in female mouse offspring after ischemic stroke.

Disruption of folate metabolism causes poor alignment and spacing of mouse conceptuses for multiple generations

This study shows that disrupted folate metabolism in mice causes conceptus misalignment and developmental issues across generations, independent of maternal uterine factors.

A dietary vitamin B12 deficiency impairs motor function and changes neuronal survival and choline metabolism after ischemic stroke to the sensorimotor cortex in middle aged male and female mice

Dietary folic acid deficiency impacts hippocampal morphology and cortical acetylcholine metabolism in adult male and female mice

This study examines the effects of dietary folic acid deficiency on hippocampal morphology and cortical acetylcholine metabolism in male and female mice, finding sex differences in hippocampal apoptosis but not in morphology or acetylcholine levels.

Independent and Combined Associations of 677C/T and 1298A/C Polymorphisms in the MTHFR gene with Breast Cancers in a South-Asian Population

The paper analyzes the associations of MTHFR SNPs 677C/T and 1298A/C with breast cancer risk in a South-Asian population, finding significant diplotype effects but no independent SNP associations.

Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight

This study uses Mendelian Randomization to assess the causal effect of maternal vitamin B12 and folate on offspring birthweight, finding a positive causal effect for folate but not for B12.

C. elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor

The paper identifies two mechanisms by which vitamin B12 regulates the methionine/S-adenosylmethionine cycle in C. elegans, involving transcriptional adjustments via nuclear hormone receptors.

Mutagenicity of folic acid deficiency and supplementation is tissue-specific and results in distinct mutation profiles

This study examines how folic acid deficiency and supplementation affect mutation rates in bone marrow and colon, revealing tissue-specific mutagenic effects.

Mendelian randomisation study exploring the associations of serum folate with pan and site-specific cancers

This paper uses Mendelian randomisation to investigate the causal relationship between genetically predicted serum folate levels and cancer risk, finding little evidence of a causal association.

Methylenetetrahydrofolate reductase deficiency alters cellular response after ischemic stroke in male mice

This study investigates how MTHFR deficiency in mice affects cellular responses after ischemic stroke, finding increased antioxidant activity and altered MAT2A and HIF-1 levels.

Vitamin B12 is neuroprotective in experimental pneumococcal meningitis through modulation of hippocampal DNA methylation

This study shows vitamin B12 reduces hippocampal apoptosis and inflammation in a rat model of bacterial meningitis by modulating DNA methylation and homocysteine levels.

MTHFR gene A1298C polymorphism and Alzheimer’s disease susceptibility

A meta-analysis of ten case-control studies found no significant association between MTHFR A1298C polymorphism and Alzheimer's disease risk across most genetic models.

Folic acid, but not folate, regulates different stages of neurogenesis in the ventral hippocampus of adult female rats

This study investigates how different doses of natural folate or synthetic folic acid affect neurogenesis, homocysteine, and corticosterone in adult female rats.

C. elegans Multidrug Resistance Protein 5 (MRP-5) Transports Vitamin B12 from the Intestine to the Gonad to Support Embryonic Development

An evidence-based approach to globally assess the covariate-dependent effect of MTHFR SNP rs1801133 on plasma homocysteine: a systematic review and meta-analysis

This paper assesses how the MTHFR SNP rs1801133 affects plasma homocysteine levels, considering covariates like folic acid intake, and finds significant variability due to effect modification and confounding.