Cancer-related Molecular Pathways

p53 is a selective barrier to chromosome loss in cancer

This study shows p53 inactivation is not universally linked to aneuploidy but is associated with increased chromosome loss in cancer.

Gain of Function p53 mutant R273H confers distinct methylation profiles and consequent partial or full EMT states to colon tumour

The paper analyzes methylation and transcriptomic data to show that p53 R273H mutation in colon cancer is linked to partial or full EMT states and metastasis.

Sequential PIDD1 auto-processing is essential for ploidy control in liver and heart

This study shows that sequential auto-processing of PIDD1 is essential for controlling ploidy in liver and heart development, with distinct roles for caspase-2 in different cell types.

CDKN1A (p21Cip/Waf1) stabilizes Cyclin D3 by inhibiting its phosphorylation-dependent nuclear export following butyrate treatment

This study shows CDKN1A stabilizes cyclin D3 by inhibiting its phosphorylation-dependent nuclear export after butyrate treatment, revealing a mechanism for butyrate-induced cell cycle arrest.

Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration

This paper shows that TP53 represses SOX2 in cancer cells, affecting cell identity and migration, with implications for metastasis in breast cancer.

Single-cell transcriptomics uncovers that cell-to-cell communication controls p53 activation

The paper uses single-cell RNA sequencing to show that cell-to-cell communication enhances p53 activation in response to chemotherapy, revealing a role for paracrine signaling in treatment response.

p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration

This study identifies ZMAT3 as a regulator of HKDC1 transcription through JUN, suppressing mitochondrial respiration in colorectal cancer cells.

Integrative multiomic approaches reveal ZMAT3 and p21 as conserved hubs in the p53 tumor suppression network

The paper identifies ZMAT3 and CDKN1A as key hubs in the p53 tumor suppression network through integrative multiomic analyses in a mouse model.

Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation

This study identifies that Δ133p53α and Δ160p53α isoforms exert a dominant-negative effect on p53 by co-aggregating with full-length p53, disrupting its function.

P53 deficiency triggers hypertranscription, inducing nucleotide insufficiency causing replication stress, and genomic instability

This study shows that p53 deficiency causes hypertranscription and nucleotide insufficiency, leading to replication stress and genomic instability, including chromothripsis.

Oncogenic and teratogenic effects of Trp53Y217C, an inflammation-prone mouse model of the human hotspot mutant TP53Y220C

This study shows that the p53Y217C mutation causes inflammation, leading to oncogenic effects in male mice and teratogenic effects in female mice, with anti-inflammatory treatment improving female survival.

A Dual-Action Liposome-Peptide Formulation Synergistically Counteracts A Gain-of-Function p53 Mutant

This paper develops a liposome-peptide formulation that enhances doxorubicin's effectiveness against p53R273H mutant tumors by disrupting PC4 interaction.

Obligate intracellular Orientia tsutsugamushi impedes TP53 expression to inhibit DNA damage-induced apoptosis

This study shows that Orientia tsutsugamushi downregulates TP53 to block DNA damage-induced apoptosis and promote bacterial replication.

Mis-splicing Drives Loss of Function of p53E224D Point Mutation

The paper investigates a p53 mutation that causes mis-splicing and loss of function in vitro and in vivo, challenging the classical view of p53 tumor suppression.

Pulsed stimuli entrain p53 to synchronize single cells and modulate cell-fate determination

This study shows that p53 oscillations can be entrained by periodic DNA damage stimuli, leading to synchronized cell responses and altered cell-fate outcomes.

Novel transcription factor BTNL9 enhances tumor suppression and drug sensitivity in non-small cell lung cancer through cell cycle regulation

This study identifies BTNL9 as a tumor suppressor in non-small cell lung cancer, showing it regulates cell cycle genes and enhances drug sensitivity through transcriptional control.

CD8 T lymphocytes redeploy embryonic cell cycle control mechanisms to facilitate rapid cell proliferation

This study identifies shared cell cycle control mechanisms between CD8 T cells and embryonic stem cells, revealing similarities in cyclin expression and Emi1 function that support rapid proliferation.

Structural and functional analysis of cancer-associated missense variants in the retinoblastoma protein (Rb) pocket domain

This study analyzes how cancer-associated missense variants in Rb's pocket domain affect its binding and stability using biophysical assays and crystallography.

Human Adenovirus (HAdV) mediated inhibition of the tumor suppressor p53 is controlled by SUMOylation of the viral E2A/DBP protein

This study identifies SUMOylation of HAdV E2A/DBP as a mechanism to inhibit p53 activity and apoptosis, revealing a novel pathway for viral oncogenic potential.

p53motifDB: integration of genomic information and tumor suppressor p53 binding motifs

The paper introduces p53motifDB, a database integrating genomic data and p53 binding motifs to help generate hypotheses about p53 activity in the human genome.

Extended role of p21 during the exit from p21-induced G0/G1 arrest

This study reveals that p21 continues to play a role in cell cycle re-entry after G0/G1 arrest, beyond its initial inhibitory function.

Pro-survival roles for p21(Cip1/Waf1) in Non-Small Cell Lung Cancer

This study shows that p21Cip1/Waf1 promotes survival and relapse in TP53 wild-type NSCLC by enabling quiescence and protecting cells from chemotherapy.

tp53 R217H and R242H Mutant Zebrafish Exhibit Dysfunctional p53 Hallmarks and Recapitulate Li-Fraumeni Syndrome Phenotypes

This study characterizes zebrafish models of Li-Fraumeni syndrome with TP53 mutations, showing dysfunctional p53 pathways, tumor development, and mutation-specific phenotypes.

Combined inhibition of MDM2 and PARP lead to a synergistic anti-tumoral response in p53 wild-type rhabdomyosarcoma models

This study shows that combining MDM2 and PARP inhibitors synergistically inhibits p53 wild-type rhabdomyosarcoma growth in vitro and in vivo.

Copper induces p53 unfolding in cancer cells, resulting in invasion and chemoresistance

The paper shows copper induces p53 unfolding in cancer cells, leading to invasion and chemoresistance, with partial restoration by the chelator Trien.

Fine resolution clustering of TP53 variants into functional classes predicts cancer risks and spectra among germline variant carriers

Resistance of E2F4DN to p38MAPK phosphorylation attenuates DNA damage-induced neuronal death via Cited2

The paper shows that E2F4DN, a non-phosphorylatable mutant of E2F4, reduces neuronal death by upregulating Cited2, suggesting its neuroprotective role in Alzheimer's disease.

Evolution of the Cdk4/6-Cdkn2 system in invertebrates

This study examines the evolution of Cdk4/6 and Cdkn2 in invertebrates, finding that Cdkn2 distribution is uneven and linked to Faf1, with conserved positive charge in Cdk4/6 in species with Cdkn2.

p53 isoforms have a high aggregation propensity, interact with chaperones and lack binding to p53 interaction partners

Mutant IDH uncouples p53 from target gene regulation to disable tumor suppression

This paper shows that mutant IDH disrupts p53 target gene regulation by altering chromatin states, disabling tumor suppression, and that this effect can be reversed with IDH inhibition.