Adipose Tissue and Metabolism

Non-Contrast microCT Analysis of Obese Adipose in Response to Cold-Exposure Reveals Sex-Specific Alterations

This study uses non-contrast microCT to analyze obese adipose tissue in mice exposed to cold, revealing sex-specific thermogenic adipose formation and metabolic changes.

CCT-217: A Landmark Gene Silencing Therapeutic for Weight Loss That Enhances Lean Mass Composition, Reduces Visceral, Subcutaneous Fat and Restores Metabolic Health in Obesity through Browning

CCT-217, an siRNA therapy targeting CB1R and ZFP423, reduces body weight and visceral fat while preserving lean mass and improving metabolic health in obese mice.

The Mitochondrial Brown Adipose Tissue Maintenance Factor Nipsnap1 Interfaces Directly with the Beta-Oxidation Protein Machinery.

This study shows that Nipsnap1 overexpression in mice increases energy expenditure and lipid beta-oxidation, linking peroxisomal and mitochondrial beta-oxidation pathways to sustain thermogenic fat activation.

Brown Bears activates a Satiety Hormone Cholecystokinin (CCK) pathway in adipose tissue during hibernation

This study identifies a seasonal regulation of satiety-related genes and proteins in brown bear adipose tissue during hibernation, suggesting a local mechanism for energy management and satiety.

PFKFB3 protein in adipose tissue contributes to whole body glucose homeostasis

This study shows that PFKFB3 in adipose tissue affects glucose metabolism and metabolic health, particularly with aging and high-fat diets.

White adipose tissue browning preserves UCP1-dependent nonshivering thermogenesis upon brown-adipocyte specific lipase-deficiency

The paper shows that browning of white adipose tissue maintains UCP1-dependent thermogenesis despite loss of lipases in brown adipocytes.

Establishing immortalized brown and white preadipocyte cell lines from young and aged mice

This paper establishes protocols for creating immortalized brown and white preadipocyte cell lines from young and aged mice to enable long-term studies of adipogenesis and adipocyte biology.

Upregulation of Inhibitor of DNA Binding 1 and 3 is Important for Efficient Thermogenic Response in Human Adipocytes

The paper shows that ID1 and ID3 upregulation is crucial for thermogenic response in human adipocytes under adrenergic stimulation.

PPARγ activation by lipolysis-generated ligands is required for cAMP dependent UCP1 induction in human thermogenic adipocytes

HuR-dependent expression of RyR2 contributes to calcium-mediated thermogenesis in brown adipocytes

This study identifies HuR-dependent regulation of RyR2 expression as critical for calcium-mediated thermogenesis in brown adipocytes, showing that HuR stabilizes RyR2 mRNA to enhance calcium cycling and heat production.

TRPV4 modulation affects mitochondrial parameters in adipocytes and its inhibition upregulates lipid accumulation

This study shows TRPV4 inhibition increases lipid accumulation in adipocytes by altering mitochondrial parameters and lipid-droplet formation.

Depot-Specific mRNA Expression Programs in Human Adipocytes Suggest Physiological Specialization via Distinct Developmental Programs

The paper shows that human adipocytes from different anatomical depots have distinct gene expression programs, suggesting depot-specific developmental programming rather than just environmental adaptation.

AQP1- A regulatory factor associated with brown adipose tissue silencing

This study identifies AQP1 as a BAT silencing factor and shows that its knockout activates NST under cold conditions, protecting against diet-induced obesity and metabolic dysfunction.

TBX15 regulates a network of immune response genes in adipose tissue and alters fat mass and depot weight in heterozygous knockout mice

Reversing Pdgfrβ Signaling Restores Metabolically Active Beige Adipocytes by Alleviating ILC2 Suppression in Aged and Obese Mice

This study shows that reversing Pdgfrβ signaling in aged and obese mice restores beige adipocyte formation and improves metabolism by enhancing ILC2 activity.

Sympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of OT-elicited reductions of body weight gain and adiposity in male diet-induced obese rats

This study investigates whether sympathetic innervation of brown adipose tissue mediates oxytocin-induced weight loss in diet-induced obese rats, finding it is not required.

Diet-induced hyperplastic expansion in subcutaneous adipose tissue and protection against adipose progenitor exhaustion in female mice are lost with ovariectomy.

This study shows that estrogen protects female mice from adipose progenitor cell exhaustion during diet-induced obesity, but this protection is lost after ovariectomy.

Insulin-Independent Regulation of Type 1 Diabetes via Brown Adipocyte-Secreted Proteins and the Novel Glucagon Regulator Nidogen-2.

This paper identifies a brown adipose tissue-secreted protein fraction that improves glycemia in T1D mice independently of insulin, with nidogen-2 as a key component that inhibits glucagon secretion.

Sympathetic neuron-derived NPY protects from obesity by sustaining the mural progenitors of thermogenic adipocytes.

This study shows that sympathetic neuron-derived NPY sustains mural progenitors of thermogenic adipocytes, protecting against obesity by maintaining thermogenic capacity.

The metabolic benefits of thermogenic stimulation are preserved in aging

This study shows that chronic beta3-AR stimulation improves metabolic function in aged mice by enhancing thermogenesis in brown adipose tissue and lipid turnover in white adipose tissue.

ScreenDMT reveals linoleic acid diols replicably associate with BMI and stimulate adipocyte calcium fluxes

The paper identifies linoleic acid diols that inversely associate with BMI and activate adipocyte calcium fluxes using a novel tool called ScreenDMT.

Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

This study identifies ADGRA3 as a GPCR that promotes adipose thermogenesis through constitutive activity and the Gs-PKA-CREB axis, with hesperetin as a potential agonist for therapeutic obesity treatment.

Sex-dependent adipose glucose partitioning by the mitochondrial pyruvate carrier

This study investigates the role of the mitochondrial pyruvate carrier (MPC) in adipose glucose partitioning, finding sex-dependent effects on triglyceride synthesis and metabolic adaptation in mice.

Sympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of oxytocin-elicited reductions of body weight and adiposity in male diet-induced obese mice

This study shows that sympathetic innervation of interscapular brown adipose tissue is not required for oxytocin-induced weight loss and thermogenesis in diet-induced obese mice.

Loss of RREB1 reduces adipogenesis and improves insulin sensitivity in mouse and human adipocytes

This study shows that reducing RREB1 in mice and humans decreases adipogenesis and improves insulin sensitivity, linking RREB1 to type 2 diabetes risk.

ZIP13 regulates lipid metabolism by changing intracellular iron and zinc balance

This study shows ZIP13 regulates lipid metabolism by modulating intracellular iron and zinc balance in adipocytes.

Adipogenic differentiation of hematopoietic lineage cells isolated from adipose tissue of humans

The paper shows human adipose tissue hematopoietic lineage cells can proliferate and differentiate into adipogenic and osteogenic lineages in vitro, supporting their role in bone marrow-derived adipocytes.

Homeodomain transcription factors in adipocyte thermogenesis: insights into the species-specific and conserved regulatory elements of human UCP1

The paper identifies species-specific and conserved regulatory elements of the human UCP1 gene using promoter analysis and transcriptome data from humans, mice, and rats.

Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue

This study examines how endurance exercise training affects rat subcutaneous white adipose tissue, revealing sex-specific molecular responses and differences in adiposity and metabolism.

Uncoupling protein 1-driven Cre (Ucp1-Cre) is expressed in the epithelial cells of mammary glands and various non-adipose tissues

This study investigates Ucp1-Cre expression in non-adipose tissues and finds it in epithelial cells during development, but not in adult mammary glands.