Adipose Tissue and Metabolism

Topical application of the cold-mimetic L-menthol decreases wheel running without affecting the beneficial effects of voluntary exercise in mice

This study shows that topical L-menthol reduces voluntary wheel running in mice but still allows exercise to improve metabolic health by increasing energy expenditure.

NR2F2 Reactivation in Early-life Adipocyte Stem-like Cells Rescues Adipocyte Mitochondrial Oxidation

This study shows that early-life exposure to high omega-6 fatty acids impairs adipocyte mitochondrial oxidation by suppressing NR2F2, which can be reversed by reactivating NR2F2 in stem-like cells.

Cysteine depletion triggers adipose tissue thermogenesis and weight-loss.

This study shows that cysteine depletion induces adipose browning and weight loss in mice, mediated by noradrenaline signaling via β3-adrenergic receptors, without requiring UCP1.

Adipose tissue protein kinase D (PKD): regulation of signalling networks and its sex-dependent effects on metabolism

This study investigates the role of PKD in adipose tissue, revealing sex-dependent effects on metabolism through phosphoproteomics and a mouse model.

Sweet science: Exploring the impact of fructose and glucose on brown adipocyte differentiation using optical diffraction tomography

This study shows that fructose impairs brown adipocyte differentiation and function in both mice and humans, affecting lipid droplet formation and adipogenic gene expression.

Vestigial like 4 regulates the adipogenesis of classical brown adipose tissue

This study identifies VGLL4 as a regulator of classical brown adipose tissue development by modulating the Hippo-YAP pathway and adipogenic gene expression.

MACanalyzeR: scRNA-seq Analysis Tool Reveals PPARγHI Lipid-Associated Macrophages Facilitate Thermogenic Expansion in BAT

The paper introduces MACanalyzeR, a scRNA-seq tool, to identify PPARγ-high lipid-associated macrophages in BAT that support thermogenic expansion.

White and Brown Adipose Tissue Share a Common Fibro-Adipogenic Progenitor Population

The paper identifies a common fibro-adipogenic progenitor population in both white and brown adipose tissue using single-cell RNA sequencing and validates its physiological relevance through comparison with in vivo data.

Novel hyperplastic expansion of white adipose tissue underlies the metabolically healthy obese phenotype of male LFABP null mice

This study shows that LFABP-null mice on a high-fat diet develop metabolically healthy obesity through increased adipocyte number rather than size in subcutaneous adipose tissue.

Dietary lipid is largely deposited in skin and rapidly affects insulating properties

The paper shows dietary lipid is deposited in skin, altering its thermal properties and energy regulation within days.

A cold-inducible phospholipid--protein interaction in brown fat mitochondria optimizes thermogenic capacity

The paper identifies LPCAT3 as a cold-regulated enzyme that generates AA-PE in BAT mitochondria, enhancing ETC efficiency and thermogenesis.

Loss of the alternative calcineurin variant CnAβ1 enhances brown adipocyte differentiation and drives metabolic overactivation through FoxO1 activation

This study shows that loss of CnAβ1 enhances brown adipocyte differentiation and metabolic activity through FoxO1 activation, leading to improved insulin sensitivity and reduced body weight on a high-fat diet.

Lipolytic and Anti-Adipogenic Effect of Capsaicin, Camphor, and Caffeic acid on Human SGBS Adipocytes

This study evaluates the lipolytic and anti-adipogenic effects of capsaicin, camphor, and caffeic acid on human SGBS adipocytes, showing reduced lipid accumulation and increased lipolysis, with capsaicin having the strongest effects.

Acute session of three endurance exercise intensities alters subcutaneous adipose tissue transcriptome in regular exercisers

This study compares the acute effects of three exercise intensities on subcutaneous adipose tissue transcriptome in regular exercisers, finding intensity-specific gene expression changes and common pathways involved in cardiometabolic health.

The non-thermogenic function of opossum UCP1 is independent of its cytoplasmic binding network.

This study investigates the thermogenic function of opossum UCP1 and finds that altered residues K100 and Y289 do not account for its lack of thermogenic activity.

Beige fat appearance during lipoatrophy reveals trade-offs between metabolic homeostasis and female fertility

This study shows that lipoatrophy in female mice leads to beige fat recruitment, which improves metabolic outcomes but reduces fertility.

Semaglutide-induced weight loss improves mitochondrial energy efficiency in skeletal muscle

This study shows semaglutide improves mitochondrial energy efficiency in skeletal muscle by enhancing ATP production per oxygen consumed during weight loss.

Housing temperature dictates the systemic and tissue specific molecular responses to cancer in mice

This study shows that housing temperature affects molecular and systemic responses to cancer in mice, influencing metabolic adaptations and cytokine levels.

Increased contact between lipid droplets and mitochondria in skeletal muscles of male elite endurance athletes

This study finds that male elite endurance athletes have greater lipid droplet-mitochondria contact in skeletal muscle compared to recreationally active individuals, linked to higher organelle densities and specific size-related associations.

Pharmacological Inhibition of SUMOylation with TAK-981 Mimics Genetic HypoSUMOylation in Murine Perigonadal White Adipose Tissue

This study shows that inhibiting SUMOylation with TAK-981 in mice reduces adipose tissue weight and adipocyte size, mimicking genetic hypoSUMOylation effects.

Non-invasive and unbiased assessment of thermogenesis in mice through thermal gradient ring

This study evaluates the Thermal Gradient Ring as a non-invasive method to assess thermogenesis in mice by analyzing temperature preference and behavior.

CETP expression in females increases body metabolism under both cold exposure and thermoneutrality contributing to a leaner phenotype

This study shows CETP expression in female mice increases body metabolism under cold exposure and thermoneutrality, leading to a leaner phenotype through enhanced BAT activity and muscle metabolism.

Igf2 regulates early postnatal DPP4+ preadipocyte pool expansion

The paper identifies Dpp4+ preadipocytes in pre-wean mice and shows Igf2 promotes their expansion, which drives adipogenesis.

Piezo2 in sensory neurons influences systemic and adipose tissue metabolism

This study shows that Piezo2 in sensory neurons regulates brown and beige fat metabolism, preventing systemic hypermetabolism and improving insulin sensitivity.

The autophagy receptor Ncoa4 controls PPARγ activity and thermogenesis in brown adipose tissue

This study identifies Ncoa4 as a regulator of PPARγ activity and thermogenesis in brown adipose tissue through genetic and functional analyses.

Human subcutaneous and visceral adipocyte atlases uncover classical and specialized adipocytes and depot-specific patterns

The paper uses snRNA-seq to analyze human subcutaneous and visceral adipose tissue, identifying classical and specialized adipocyte subtypes and depot-specific patterns.

Brown Adipose Tissue undergoes pathological perturbations and shapes C2C12 myoblast homeostasis in the SOD1-G93A mouse model of Amyotrophic Lateral Sclerosis.

The paper investigates changes in brown adipose tissue and its extracellular vesicles in an ALS mouse model, showing their impact on myoblast homeostasis and muscle atrophy.

Does repeated administration of baclofen in free feeding rats reduce body weight by stimulating brown fat metabolism through activation of the sympathetic nervous system?

This study tests if baclofen reduces body weight in rats by stimulating brown fat metabolism via the sympathetic nervous system, but finds propranolol does not block this effect.

Mitochondrial ATP-Sensitive K+ Channels (MitoKATP) Regulate Brown Adipocyte Differentiation and Metabolism

This study shows that MitoKATP channels regulate brown adipocyte differentiation and metabolism, impacting thermogenesis through effects on oxygen consumption and cellular respiration.

Embryonic macrophages in brown adipose tissue are spatially associated with developing nerves

The paper identifies fetal liver-derived macrophages in embryonic BAT that interact with developing nerves, influencing tissue morphology and function.