Adipose Tissue and Metabolism

A Spatiotemporal Proteomic Map of Human Adipogenesis

This study creates a spatiotemporal proteomic map of human adipogenesis, revealing changes in protein abundance, localization, and metabolic pathway reprogramming during adipocyte differentiation.

The Notch-Pdgfr beta axis suppresses brown adipocyte progenitor differentiation in early postnatal mice

This study identifies PDGFRβ+ pericytes as developmental brown adipocyte progenitors and shows that inhibiting the Notch/PDGFRβ axis promotes brown adipogenesis and improves metabolic health.

Adaptive thermogenesis is mediated by GDF15 via the GFRAL neuronal axis in mice

This study identifies the GFRAL neuronal axis as critical for GDF15-mediated adaptive thermogenesis in white adipose tissue under mitochondrial stress.

Eugenol mimics exercise to promote skeletal muscle fiber remodeling and myokine IL-15 expression by activating TRPV1 channel

This study shows eugenol improves endurance and muscle fiber remodeling in mice by activating TRPV1 and the CaN signaling pathway, leading to increased IL-15 expression.

A distinct subpopulation of adipocytes in adult perirenal adipose tissue arises through brown-to-white conversion but reverts to a thermogenic phenotype upon cold exposure

The paper identifies a unique subpopulation of adipocytes in mouse perirenal adipose tissue that originates from brown-to-white conversion and reverts to a thermogenic state under cold exposure.

Systems genetics analysis of human body fat distribution genes identifies Wnt signaling and mitochondrial activity in adipocytes

The paper identifies key driver genes affecting adipocyte function and body fat distribution using systems genetics and experimental validation.

Reconstructing human Brown Fat developmental trajectory in vitro

This study uses single-cell RNA sequencing to identify brown fat precursors and demonstrates their in vitro differentiation into functional brown adipocytes.

HDAC11 inhibition triggers bimodal thermogenic pathways to circumvent adipocyte catecholamine resistance

This study shows that inhibiting HDAC11 in adipocytes increases UCP1 expression and thermogenesis, even when beta-AR signaling is blocked.

Comprehensive analysis of intercellular communication in thermogenic adipose niche

The paper analyzes intercellular communication in brown adipose tissue using single-cell transcriptomics and identifies temperature-regulated signaling interactions.

Manipulating mitochondrial dynamics in the NTS prevents diet-induced deficits in brown fat morphology and glucose uptake

The paper shows that manipulating mitochondrial dynamics in NTS-astrocytes affects BAT glucose uptake and metabolism in response to high-fat diets.

Nipsnap1- A Regulatory Factor Required for Long-Term Maintenance of Non-Shivering Thermogenesis

This study identifies Nipsnap1 as a critical regulator required for the long-term maintenance of non-shivering thermogenesis in brown adipose tissue.

Supraclavicular brown adipocytes originate from Tbx1+ myoprogenitors

This study identifies Tbx1+ myoprogenitors as the developmental origin of supraclavicular brown adipocytes in mice and shows their relevance in human deep neck BAT.

Single-cell lineage tracing reveals hierarchy and mechanism of adipocyte precursor maturation

The paper uses single-cell RNA sequencing to identify new adipocyte precursor populations and reveals Sox9's role in adipose commitment.

Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming

This study shows aging impairs beige adipogenesis and adipocyte metabolic responses to cold, identifies Npr3 as a marker gene, and provides insights into age-related adipose tissue dysfunction.

Submitochondrial Protein Translocation in Thermogenic Regulation

The paper identifies stress-induced submitochondrial protein translocation as a mechanism regulating thermogenesis and obesity by mobilizing proteins from the mitochondrial inner membrane into the matrix.

Deep proteome profiling of white adipose tissue reveals marked conservation and distinct features between different anatomical depots

The paper compares proteomics profiles of subcutaneous and visceral adipose tissue in mice to identify depot-specific differences and responses to diet.

Pgc-1α is an exercise-responsive regulator of myosteatosis in older individuals

This study identifies Pgc-1α as a regulator of fat accumulation in aged skeletal muscle by analyzing transcriptomic responses to exercise and immobilization.

Profiling Mouse Brown and White Adipocytes to Identify Metabolically Relevant Small ORFs and Functional Microproteins

The paper identifies and characterizes small ORFs and microproteins in adipose cells, showing their metabolic relevance and potential roles in obesity and inflammation.

Circadian reprogramming of adipose progenitor cells regulates intermittent fasting-mediated adipose tissue remodeling and metabolic improvement

This study shows that intermittent fasting reduces WAT fibrosis and improves metabolism in aged mice by modulating adipose progenitor cell circadian rhythms.

Brown adipocytes local response to thyroid hormone is required for adaptive thermogenesis in adult male mice

This study shows that thyroid hormone signaling in brown adipocytes is essential for thermogenesis by regulating lipid and glucose metabolism and BAT proliferation.

A Neurogenic Signature Involving Monoamine Oxidase-A controls Human Thermogenic Adipose Tissue Development

The paper identifies a neurogenic signature involving MAOA that controls human thermogenic adipose tissue development and shows its therapeutic potential for metabolic disease.

Growth hormone receptor (GHR) in AgRP neurons regulatesthermogenesis in aged mice in a sex-specific manner

This study shows that GHR in AgRP neurons affects thermogenesis in aged mice, with sex-specific differences in body temperature and BAT gene expression.

Single-nuclei Transcriptome of Human Adipose Tissue Reveals Metabolically Distinct Depot-Specific Adipose Progenitor Subpopulations

The paper uses single-nuclei RNA sequencing to identify depot-specific adipose progenitor subpopulations in human visceral and subcutaneous adipose tissue, revealing distinct metabolic features and potential roles in obesity-related dysfunction.

ADGRG6 promotes adipogenesis and is involved in sex-specific fat distribution

This study identifies ADGRG6 as a gene involved in adipogenesis and sex-specific fat distribution, showing its potential as a therapeutic target for metabolic disease.

Remodeling of gene regulatory networks underlying thermogenic stimuli-induced adipose beiging

This study identifies common and distinct chromatin accessibility changes in adipose tissue from mice exposed to cold or Adrb3 agonists, revealing unique functional consequences of these stimuli on lipid composition and thermogenesis.

Transcriptional control of adipogenesis by PATZ1

This study identifies PATZ1 as an adipogenic transcription factor that promotes adipogenesis through DNA binding and protein interactions, and its loss protects against diet-induced obesity.

Comprehensive transcriptional profiling and mouse phenotyping reveals dispensable role for adipose tissue selective long noncoding RNA Gm15551

The paper investigates the role of the adipose tissue-specific lncRNA Gm15551 in BAT activation through transcriptional profiling and phenotyping, finding no significant effect on adipocyte function.

Photoperiod modulates mu-opioid receptor availability in brown adipose tissue

This study investigates how photoperiod affects mu-opioid receptor availability in brown adipose tissue using PET imaging and immunofluorescence in rats.

Visualization of Sympathetic Neural Innervation in Human White Adipose Tissue

This paper develops a protocol to visualize sympathetic nerve terminals in human white adipose tissue using optical clearing and light sheet confocal microscopy.

Antagonistic regulation of Drosophila mitochondrial uncoupling protein UCP4b by cold and BMP signaling

This study identifies UCP4b as a cold-inducible gene in Drosophila that protects against cold and obesity, regulated by calcium signaling and counteracted by BMP signaling via MAD.