interferon and immune responses

Double stranded RNA drives innate immune responses, sickness behavior and cognitive impairment dependent on dsRNA length, IFNAR1 expression and age

The paper investigates how dsRNA length, IFNAR1 expression, and age affect innate immune responses and cognitive impairment in mice using poly I:C.

Innate immunity mediator STING modulates nascent DNA metabolism at stalled forks in human cells

This study shows that STING modulates nascent DNA degradation at stalled replication forks, linking replication stress to innate immunity.

IFN-{lambda}4 is associated with increased risk and earlier occurrence of gastrointestinal, respiratory and malarial infections in Malian children

This study finds that genetic variants affecting IFN-λ4 production are linked to increased risk and earlier occurrence of gastrointestinal, respiratory, and malaria infections in Malian children.

High dose IFN-β activates GAF to enhance expression of ISGF3 target genes in epithelial cells

The paper shows that high-dose IFN-β activates both ISGF3 and GAF in epithelial cells, with GAF enhancing ISGF3 target gene expression through co-localization and chromosome looping.

Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback

The paper models the complete kinetics of coxsackievirus B3 to identify human determinants of host-cell feedback, revealing that MAVS cleavability influences viral outcomes.

Nuclear sensing of mitochondrial DNA breaks enhances immune surveillance

The paper shows that mitochondrial DNA breaks trigger a type I interferon response through nuclear sensing, enhancing immune surveillance against genotoxic stress.

ER-directed TREX1 limits cGAS recognition of micronuclei

This study shows TREX1 limits cGAS recognition of micronuclear DNA by degrading it after micronuclear envelope rupture, and a TREX1 mutation disrupts this process, enhancing immune sensing.

Regulation of early growth response-1 (Egr-1) gene expression by Stat1-independent type I interferon signaling and respiratory viruses

This study shows that Egr-1 is induced by IFN-β, TLR ligands, and respiratory viruses independently of the Stat1 pathway and is involved in antiviral response and inflammation.

Profiling transcription factor sub-networks in type I interferon signaling and in response to SARS-CoV-2 infection

The paper profiles transcription factor sub-networks in type I interferon signaling and SARS-CoV-2 infection to identify differential regulation in immune and lung cells.

MISTR: A conserved MItochondrial STress Response network revealed by signatures of evolutionary conflict

The paper identifies a conserved mitochondrial stress response network (MISTR) by analyzing evolutionary conflict signatures across species, revealing its role in stress response and pathogen resistance.

Identification of Interleukin1β as an Amplifier of Interferon alpha-induced Antiviral Responses

This study identifies IL1β as an amplifier of IFN-induced antiviral responses through mathematical modeling and experimental validation.

Cell cycle-gated feedback control mediates desensitization to interferon stimulation

The paper investigates how type I interferon signaling in human epithelial cells processes repetitive stimulation through cell cycle-gated feedback control, revealing duration-dependent desensitization.

Induction of RNA interference by C. elegans mitochondrial dysfunction via the DRH-1/RIG-I homologue RNA helicase and the EOL-1/RNA decapping enzyme

This study shows that mitochondrial dysfunction in C. elegans activates RNAi through a pathway similar to the mammalian RIG-I response, involving DRH-1 and EOL-1, and contributes to increased longevity.

Alpha-synuclein supports interferon stimulated gene expression in neurons

This study shows alpha-synuclein is required for interferon-stimulated gene expression in neurons during RNA virus infection and links it to phosphorylated S129-asyn pathology.

ILF3 contributes to the establishment of the antiviral type I interferon program

The paper identifies ILF3 as a host factor essential for translating antiviral cytokines and interferon-stimulated genes during dsRNA-induced antiviral responses.

Dynamic rewiring of the human interactome by interferon signalling

This study maps the dynamic changes in the human protein-protein interaction network induced by interferon signaling, revealing novel regulatory mechanisms and functional contexts for interferon-stimulated genes.

The Arabian camel, Camelus dromedarius interferon epsilon: functional expression, in vitro refolding, purification and cytotoxicity on breast cancer cell lines MDA-MB-231 and MCF-7

This study clones, expresses, and purifies camel interferon epsilon, showing its cytotoxic effects on breast cancer cell lines.

MAVS polymers smaller than 80 nm induce mitochondrial membrane remodeling and interferon signaling

The paper shows MAVS polymers induced by dsRNA are smaller than 80 nm and require the transmembrane domain for mitochondrial remodeling and interferon signaling.

Recurrent loss-of-function mutations reveal costs to OAS1 antiviral activity in primates

The paper identifies recurrent loss-of-function mutations in OAS1 across primates, showing that the cytotoxic effects of OAS1 activation can outweigh its antiviral benefits, leading to reduced catalytic activity.

Genome-encoded Cytoplasmic Double-Stranded RNAs, Found in C9ORF72 ALS-FTD Brain, Provoke Propagated Neuronal Death

The paper shows that cytoplasmic double-stranded RNA (cdsRNA) from C9ORF72 expansions in ALS-FTD brains triggers IFN-I signaling and neuronal death through a viral-mimetic mechanism.

MicroRNA-122 supports robust innate immunity in hepatocytes by suppressing STAT3 phosphorylation

This study shows miR-122 enhances hepatocyte innate immunity by reducing STAT3 phosphorylation, thereby increasing interferon production against HCV and poly(I:C).

Transcription of Repeats Activates INterferon (TRAIN) in response to chromatin destabilization induced with anti-cancer small molecule

The paper shows that chromatin destabilizing drugs like curaxin induce an interferon response (TRAIN) through repeat transcription, independent of p53 status, and may prevent cancer by eliminating epigenetically unstable cells.