interferon and immune responses

Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction

This study shows DUX4 and mouse Dux interact with STAT1 and inhibit IFN-gamma-induced ISG expression by reducing STAT1 and Pol-II recruitment.

IFITM3 blocks influenza virus entry by sorting lipids and stabilizing hemifusion

This study identifies how IFITM3 inhibits influenza virus entry by stabilizing hemifusion through lipid sorting in endosomal membranes.

Temporal perturbation of STAT1/2 activity reveals dynamic ligand discrimination of type I interferon signaling

The paper investigates how STAT1/2 activity differs in response to IFN and IFNβ through temporal perturbation, revealing distinct signaling dynamics and refractory states.

The Cytomegalovirus M35 Protein Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes by Direct Promoter Binding

This paper identifies M35 as a viral protein that binds DNA and inhibits IRF3-mediated gene expression, including Ifnb1, thereby suppressing the antiviral type I IFN response.

Leaked genomic and mitochondrial DNA contribute to the host response to noroviruses in a STING-dependent manner

This study shows that the cGAS-STING pathway restricts noroviruses by detecting leaked genomic and mitochondrial DNA, leading to IFN responses.

Epigenetic signals that direct cell type specific interferon beta response in mouse cells

The paper identifies epigenetic features that regulate cell type-specific interferon beta responses in mouse cells by analyzing chromatin and gene expression changes.

The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction

The paper identifies HELZ2 as an ISG protein that inhibits LINE-1 retrotransposition and reduces IFN- induction by interacting with L1 RNA and ORF1p.

Constitutively active STING causes neuroinflammation and degeneration of dopaminergic neurons in mice

This study shows that constitutively active STING in mice leads to neuroinflammation and dopaminergic neuron degeneration, suggesting therapeutic targeting of this pathway.

The proto-oncogene c-Src phosphorylates cGAS to reduce DNA binding and activation

This study shows that c-Src phosphorylates cGAS, reducing its DNA binding and activation, thereby inhibiting anti-tumor immune responses in cancer.

Impaired activation of Transposable Elements in SARS-CoV-2 infection

This study investigates TE activation in SARS-CoV-2 infection, finding it induces a weaker IFN response compared to other viruses, with TE expression and viral load explaining immune response diversity.

Genetic regulation of OAS1 nonsense-mediated decay underlies association with risk of severe COVID-19

The paper identifies a Neandertal introgressed haplotype in the OAS1 gene associated with increased risk of severe COVID-19 and shows it impairs SARS-CoV-2 clearance through genetic regulation of OAS1 expression.

The mechanism of DNA sensor cGAS-STING regulating autophagy-related signal pathways

This study identifies how cGAS-STING regulates autophagy through multiple pathways, including mTOR inhibition, autophagy-related protein regulation, and interactions with Bcl2 and USP19.

Small cytosolic dsDNAs repress cGAS activation and induce autophagy

The paper identifies small cytosolic DNAs (scDNAs) that inhibit cGAS activation and induce autophagy, preventing excessive inflammation.

Ifit2 regulates murine-coronavirus spread to the spinal cord white matter and its associated myelin pathology

This study shows that Ifit2 deficiency in mice leads to severe viral spread and demyelination in the spinal cord during chronic RSA59 infection.

Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19

This study identifies IFN pathway lupus risk alleles associated with COVID-19 mortality and develops predictive models combining genetics and biomarkers.

ISG15 Monomer Promotes IFNα-mediated Antiviral Activity against Pseudorabies Virus by Facilitating phosphorylation of STAT1/STAT2

This study shows ISG15 monomer enhances IFNα antiviral activity against PRV by promoting STAT1/STAT2 phosphorylation and reducing viral replication.

High content screening and computational prediction reveal viral genes that suppress innate immune response

The paper develops a high-content assay to identify viral genes that suppress innate immunity and validates known and novel immune suppressors from various viral families.

N-phosphonacetyl-L-aspartate enhances type I interferon anti-viral responses through activation of non-canonical NOD2 signaling

This study shows that PALA enhances antiviral responses by activating non-canonical NOD2 signaling, improving type I interferon production and ISG expression.

Role of RIGI, MDA5 and interferon alpha of duck in Duck Plague infection, a novel report

The paper investigates the role of RIG1, MDA5, and INFalpha in duck plague infection using in silico and experimental methods to understand host innate immunity.

Recognition of HIV-1 capsid licenses innate immune response to viral infection

The paper identifies a two-factor authentication mechanism used by the innate immune system to detect low-abundance HIV-1 DNA through PQBP1-mediated capsid recognition and cGAS recruitment.

LY6S, a New Interferon-Inducible Human Member of the Ly6a-Subfamily Expressed by Spleen Cells and Associated with Inflammation and Viral Resistance

The paper identifies LY6S, a new human interferon-inducible gene associated with inflammation and viral resistance, and describes its expression and functional effects.

Heterogeneity of monocyte subsets and susceptibility to influenza virus contribute to inter-population variability of protective immunity

The paper investigates monocyte subset heterogeneity and its impact on influenza virus susceptibility across populations, revealing differences in transcriptional responses and infection resistance between African and European ancestry individuals.

Multicellular Spatial Model of RNA Virus Replication and Interferon Responses Reveals Factors Controlling Plaque Growth Dynamics

The paper develops a spatial multicellular model of RNA virus replication and interferon responses, showing how interferon concentrations and diffusion rates affect plaque growth dynamics.

Surfaceome CRISPR Screen Identifies OLFML3 as a Rhinovirus-inducible IFN Antagonist

The paper identifies OLFML3 as a rhinovirus-inducible IFN antagonist using surfaceome CRISPR screening, showing its role in suppressing innate immunity.

Interferon induction and not replication interference mainly determines anti-influenza virus activity of defective interfering particles

This study shows that defective interfering particles (DIPs) primarily exert antiviral activity through interferon (IFN) system activation rather than suppression of viral replication.

FTO suppresses STAT3 activation and modulates proinflammatory interferon-stimulated gene expression

The paper shows FTO suppresses proinflammatory ISG expression by inhibiting STAT3 activation during the type I IFN response.

TRIM25 inhibits Influenza A infection by destabilising its mRNA and is redundant for the RIG-I pathway.

This study shows TRIM25 inhibits Influenza A virus by destabilizing its mRNA and is not required for the RIG-I pathway.

Novel antiviral interferon sensitive genes unveiled by correlation-driven gene selection and integrated systems biology approaches.

The paper identifies novel antiviral interferon-sensitive genes using correlation-driven gene selection and systems biology approaches in HCV-permissive cells.

The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signalling

This paper shows that the SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling in human cells.

Single-cell transcriptomics reveals immune response of intestinal cell types to viral infection

The paper uses single-cell RNA-Seq and imaging to study how intestinal cell types respond to viral infection, finding that each lineage has unique antiviral responses.