A. Kumar

Deep proteomics network and machine learning analysis of human cerebrospinal fluid in Japanese encephalitis virus infection

This study identifies a ten-protein diagnostic signature for Japanese encephalitis virus infection in cerebrospinal fluid with >99% accuracy using proteomics and machine learning.

Protective efficacy of COVAXIN(R) against Delta and Omicron variants in hamster model

This study evaluates COVAXIN's protective efficacy against Delta and Omicron variants in hamsters, showing improved protection with a third dose and reduced disease severity.

Strengthening of enterococcal biofilms by Esp

This study investigates the role of Esp in strengthening enterococcal biofilms under acidic conditions, showing that Esp unfolding and aggregation enhance biofilm stability.

SAM-dependent viral MTase inhibitors: herbacetin and caffeic acid phenethyl ester, structural insights into dengue MTase

The paper identifies herbacetin and caffeic acid phenethyl ester as inhibitors of dengue and chikungunya virus MTases, revealing their mechanism of action and antiviral efficacy.

Transcriptional signature pattern in black, blue and purple wheat and impact on seed pigmentation and other associated features: Comparative transcriptomics, genomics and metabolite profiling

The paper investigates anthocyanin biosynthesis in pigmented wheat seeds using transcriptomics, genomics, and metabolite profiling to identify gene regulation patterns and their impact on seed color and traits.

Tau seeds translocate across the cell membrane to initiate aggregation

This study identifies a novel mechanism by which tau seeds enter cells and initiate aggregation through direct translocation across the plasma membrane, independent of endocytosis.

Stem Cell Secretome Promotes Scarless Corneal Wound Healing and Rescues Corneal Sensory Nerves

This study shows that corneal stromal stem cell secretome promotes scarless corneal wound healing and rescues sensory nerves by reducing inflammation, fibrosis, and complement-mediated cell death.

Green emitting carbon quantum dots (GCQDs) to probe endocytic pathways in cells; for tissue and in vivo bioimaging

This study synthesizes green emitting carbon quantum dots (GCQDs) for in vitro and in vivo bioimaging, showing their uptake via clathrin-mediated pathways in mouse cells and zebrafish embryos.

Hippo Signaling Pathway Activation during SARS-CoV-2 Infection Contributes to Host Antiviral Response

This study identifies Hippo signaling pathway activation as an antiviral response to SARS-CoV-2 infection and shows pharmacological targeting of the pathway can reduce virus replication.

Cell-free mutant analysis combined with structure prediction of a lasso peptide biosynthetic protein B2

The paper combines cell-free mutagenesis with AlphaFold2 structure prediction to validate the function of TfuB2, revealing a hydrophobic binding site for TfuB1.

KSHV Topologically Associating Domains in Latent and Reactivated Viral Chromatin

This paper reveals the 3D chromatin structure of KSHV during latency and reactivation, showing similar TAD organization and reorganization of regulatory units.

Bird community structure in a mixed forest-production landscape in the northern Western Ghats, India

The paper compares bird diversity and guild structure in cashew, rubber plantations, and forests in the Western Ghats, finding cashew plantations support similar diversity to forests while rubber plantations have lower diversity.

Collagen remodeling dictates pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation

This study shows that collagen remodeling via MMP cleavage affects pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation, with distinct impacts on tumor growth and survival.

Influence of ambient day light variations and age on the Iris-pupillary area ratio in beef cattle

This study examines the effect of ambient light and age on the Iris-pupillary area ratio (IPR) in beef cattle, finding weak and non-significant correlations.

NAC1 Modulates Autoimmunity by Suppressing Regulatory T Cell- Mediated Tolerance

This study shows NAC1 suppresses regulatory T cell-mediated tolerance by deacetylating and destabilizing FoxP3, leading to autoimmunity, and suggests targeting NAC1 could treat autoimmune disorders.

Interrogating Metabolic Interactions Between Skeletal Muscle and Liver Circadian Clocks In Vivo

The paper investigates the role of circadian clocks in liver and skeletal muscle in glucose metabolism, finding that inter-organ communication is necessary for systemic glucose homeostasis.

Network profiling of hepatocellular carcinoma targets for evidence based pharmacological approach to improve clinical efficacy

The paper identifies key HCC targets and their network proteins to suggest optimal pharmacological strategies for improved clinical efficacy in hepatocellular carcinoma.

Extensive in vitro and in vivo protein translation via in situ circularized RNAs

This paper introduces in situ circularized RNAs (icRNAs) that enable extensive protein translation in vitro and in vivo, with applications in immunization, genome targeting, and protein engineering.

Protein binding and differential distribution of calcitonin in the sub-compartments of blood: An In vitro study

This study investigates calcitonin's sub-compartmentalization in sheep blood in vitro, finding higher concentrations in WBCs and stronger protein binding in plasma and WBC membranes, which may explain its prolonged pharmacodynamic effects.

Small molecule SWELL1-LRRC8 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes

This study identifies small molecule modulators of the SWELL1-LRRC8 complex that improve glycemic control and prevent NAFLD in murine T2D by restoring insulin signaling and secretion.

Vertical HIV-1 transmission in the setting of maternal broad and potent antibody responses

This study examines maternal broadly neutralizing antibody (bnAb) specificities in HIV-transmitting and non-transmitting mothers to determine if certain bnAb specificities drive infant transmitted/founder virus selection.

Functional crosstalk between the carrier translocase machinery and YME1 complex maintains mitochondrial proteostasis and integrity

The paper identifies a functional link between the TIM22 complex and YME1 machinery in maintaining mitochondrial proteostasis and integrity, showing mutual dependence across species.

Microliter spotting and micro-colony observation: a rapid and simple approach for counting bacterial colony-forming units

This paper introduces a rapid method for counting bacterial colony-forming units using micro-colony observation, achieving results comparable to traditional dilution plating with reduced time and labor.

A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus

Pathogenicity of SARS-CoV-2 Omicron in Syrian hamsters and its neutralization with different Variants of Concern

This study evaluates the pathogenicity of SARS-CoV-2 Omicron BA.1 in Syrian hamsters and finds reduced cross-neutralization against other variants.

Quantitative Models of Lipid Transfer and Membrane Contact Formation

This paper reviews studies on lipid transfer proteins and develops quantitative models to explain lipid transfer kinetics and membrane contact site formation mechanisms.

Transient interactions drive the lateral clustering of Cadherin-23 on membrane

This study shows that transient hydrophobic interactions drive lateral clustering of cadherin-23 on membranes, enhancing cell adhesion without requiring specific cis-dimer interactions.

Correlative cryogenic montage electron tomography for comprehensive in-situ whole-cell structural studies

This paper introduces tools for montage electron tomography to improve imaging of large fields of view in cryo-electron tomography while maintaining high-resolution structural information.

Structure, dynamics, and inhibition of Staphylococcus aureus m1A22-tRNA methyltransferase

This study characterizes the structure, dynamics, and inhibition of Staphylococcus aureus TrmK, identifying a cryptic binding pocket for drug discovery.

L-type calcium channel blocker increases VEGF concentrations in retinal cells and human serum

This study investigates how L-type calcium channel blockers affect VEGF levels in retinal cells and serum, finding increased VEGF but no link to severe diabetic eye disease.