D. Chen

Leucine alleviates cytokine storm syndrome by regulating macrophage polarization via the mTORC1/LXRα signaling pathway

This study shows leucine reduces cytokine storm syndrome in mice by promoting M2 macrophage polarization via the mTORC1/LXRα signaling pathway.

Levy statistics define anxiety and depression in mice subjected to chronic stress

This paper identifies Levy statistics as a marker for anxiety and depression in mice under chronic stress, using movement patterns and machine learning for classification.

A novel virus-induced cyclic dinucleotide, 2'3'-c-di-GMP, mediates STING-dependent antiviral immunity in Drosophila

MORE IS DIFFERENT: DRUG PROPERTY ANALYSIS ON CELLULAR HIGH-CONTENT IMAGES USING DEEP LEARNING

The paper introduces MID, a deep learning method for high-content image analysis that outperforms existing tools in drug toxicity classification and compound identification.

Drug-tolerant persister B-cell precursor acute lymphoblastic leukemia cells

The paper identifies genes and pathways contributing to drug-tolerant persistence of B-cell precursor acute lymphoblastic leukemia cells under chemotherapy.

Kindlin-2 inhibits TNF/NF-kB-caspase 8 pathway in hepatocytes to maintain liver development and function

This study shows Kindlin-2 inhibits the TNF/NF-kB-caspase 8 pathway in hepatocytes, preventing liver fibrosis and dysfunction, and identifies it as a potential therapeutic target for liver diseases.

Atlas-Guided Discovery of Transcription Factors for T Cell Programming

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

Rice potassium transporter OsHAK18 mediates phloem K+ loading and redistribution

This study identifies OsHAK18 as a phloem-localized K+ transporter that mediates K+ loading and redistribution in rice, enhancing shoot K+ retention under low-K+ stress.

Injury and a program of fetal wound healing in the fetal and neonatal extrahepatic bile duct

This study investigates the fetal response to injury in extrahepatic bile ducts (EHBDs) and identifies a fetal wound healing program characterized by high molecular weight HA, which may lead to obstruction in biliary atresia.

Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

The Cation/H+ exchanger OsCAX2 is involved in cadmium tolerance and accumulation through vacuolar sequestration in rice

This study identifies OsCAX2 as a key gene for cadmium tolerance and accumulation in rice by promoting vacuolar sequestration, reducing grain cadmium levels by over 70%.

Gaq-PKD/PKCμ regulates the IkB transcription to limit the NF-kB mediated inflammatory response essential for early pregnancy

This study shows that Gaq-PKD/PKCμ regulates IκB transcription to limit NF-κB-mediated inflammation, essential for successful early pregnancy.

Tinamou egg color displacement at eco-geographical and song space overlap

The paper examines how tinamou egg coloration relates to mating signals and eco-geographical distribution, finding associations with song variables and differences in similar habitats.

A small-molecule lycorine derivative protects from obesity by targeting Na+/K+-ATPase α3 independent of food intake suppression

The paper identifies HLY72, a small-molecule derivative of lycorine, as an anti-obesity agent that targets Na+/K+-ATPase α3 in the brain, promoting lipolysis and thermogenesis without affecting food intake.

A microglia-CD4+ T cell partnership generates protective anti-tumor immunity to glioblastoma

This study identifies a microglia-CD4+ T cell interaction that enhances anti-glioblastoma immunity through IFN-gamma-mediated tumor surveillance and phagocytosis.

FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregation

This study investigates how the FTD-tau S320F mutation stabilizes local structure and promotes amyloid motif-dependent aggregation through allosteric effects.

Omicron-specific mRNA vaccine elicits potent immune responses in mice, hamsters, and nonhuman primates

This study develops an Omicron-specific mRNA vaccine that shows superior neutralizing antibody responses in mice, hamsters, and macaques compared to existing vaccines.

Metformin Alleviates Arthrofibrosis in Rat via Fibroblast Metabolic Reprogramming

This study shows metformin reduces arthrofibrosis in rats by altering fibroblast metabolism, shifting it from oxidative phosphorylation to aerobic glycolysis.

In-depth investigation of microRNA-mediated cross-kingdom regulation between Asian honey bee and microsporidian

This study investigates microRNA-mediated cross-kingdom regulation between Asian honey bee and microsporidian using RNA-seq and small RNA-seq data, identifying miRNA-target mRNA interactions and their roles in glycolysis, virulence, and immune response.

CircRNA-regulated immune response of Asian honey bee workers to microsporidian infection

This study identifies circRNAs in Asian honey bee midguts infected with Nosema ceranae and shows their role in regulating immune responses through miRNA targeting and pathway involvement.

Biosynthetic diversification of peptaibol mediates fungus-mycohost interactions

The paper investigates how peptaibol structural diversity in Trichoderma fungi mediates interactions with mycohosts, showing that these compounds are essential for inhibiting saprotrophic fungi.

Reduced Neutralization of SARS-CoV-2 Omicron Variant in Sera from SARS-CoV-1 Survivors after 3-dose of Vaccination

This study shows that SARS-CoV-1 survivors vaccinated with ZF2001 have reduced neutralization against SARS-CoV-2 Omicron compared to other variants.

Single Particle Tracking With Compressive Sensing Using Progressive Refinement Method On Sparse Recovery (spt-PRIS)

This study introduces spt-PRIS, a new single particle tracking method that improves localization in high-density datasets with overlapping PSFs, showing effectiveness for KRAS4b subpopulation analysis.

A new model of Notch signaling: Control of Notch receptor cis-inhibition via Notch ligand dimers

This study demonstrates that Notch ligand dimers mediate cis-inhibition of Notch receptor activity, introducing a new model of Notch signaling that distinguishes between ligand monomer-driven transactivation and dimer-mediated cis-inhibition.

The mitogen-activated protein kinase kinase kinase, ILK5, regulates plant purinergic receptor-mediated, innate immunity

This study identifies ILK5 as a downstream substrate of P2K1 kinase that mediates MAPK cascade activation in Arabidopsis, enhancing innate immunity through phosphorylation of MPK3/6.

Identification and calibration of ultrabright localizations to eliminate quantification error in SMLM

This paper identifies and calibrates ultrabright localizations in SMLM to improve quantification accuracy for biomolecular organization.

Versican binds collagen via its G3 domain and regulates the organization and mechanics of collagenous matrices

This study identifies versican as a collagen-binding protein that regulates collagen matrix organization and mechanics through its G3 domain.

Aggregation pheromone 4-vinylanisole promotes the synchrony of sexual maturation in female locusts

This study identifies 4-vinylanisole as an aggregation pheromone that promotes sexual maturation synchrony in gregarious female locusts through a juvenile hormone/vitellogenin pathway.

Community diversity is associated with intra-species genetic diversity and gene loss in the human gut microbiome

The paper shows that community diversity in the human gut microbiome is linked to intra-species genetic diversity and gene loss, supporting both Diversity Begets Diversity and Black Queen Hypothesis mechanisms.

SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization

This study identifies SOX4 as a critical regulator of human endometrial decidualization by modulating PGR stability and FOXO1 expression, linking its dysregulation to infertility and pregnancy complications.