D. Chen

Peramivir, an anti-influenza virus drug, exhibits potential anti-cytokine storm effects

This study shows peramivir reduces cytokine storm by inhibiting NF-κB activity in macrophages and alleviates lung injury in mice.

Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis

This study identifies Kindlin-2 as a protective factor in articular cartilage, showing its role in preventing osteoarthritis through regulation of Stat3 and Runx2 pathways.

Three amphioxus reference genomes reveal gene and chromosome evolution of chordates

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

Single-nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma

This study uses snRNA-seq and Stereo-seq to analyze the immunological microenvironment of cervical squamous cell carcinoma, identifying immune cell clusters and their associations with tumor progression and patient survival.

Molecular mechanisms governing circulating immune cell heterogeneity across different species revealed by single cell sequencing

This study uses single-cell RNA-sequencing to analyze immune cell diversity across 12 species, revealing conserved and divergent molecular mechanisms and cellular interactions.

Directional selection at gene expression level contributes to the speciation of Asian rice cultivars

The paper identifies directional selection at the gene expression level contributing to phenotypic differences between indica and japonica rice subspecies.

Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex

This study shows that Midkine suppresses AMPK activation by disrupting the LKB1-STRAD-Mo25 complex, promoting cancer cell proliferation and correlating with poor clinical outcomes in specific cancers.

Mechanical stimulation promotes enthesis injury repair by mobilizing Prx1+ cells via ciliary TGF-β signaling

Glycosaminoglycans Modulate Long-Range Mechanical Communication Between Cells in Collagen Networks

This paper shows that glycosaminoglycans (GAGs) reduce long-range mechanical communication between cells in collagen networks by preventing collagen fiber alignment.

Screening of cell-virus, cell-cell, gene-gene interactions among kingdoms of life at single cell resolution

The paper screens cell-virus and cell-cell interactions across multiple species to identify potential hosts and co-evolution patterns of viruses including SARS-CoV-2.

ADAP1 promotes latent HIV-1 reactivation by selectively tuning a T cell signaling-transcriptional axis

This study identifies ADAP1 as a factor that enhances T cell signaling and promotes HIV-1 reactivation by modulating the ERK-AP-1 axis.

Viral receptor profiles of masked palm civet revealed by single-cell transcriptomics

The paper uses single-cell transcriptomics to profile viral receptor expression in masked palm civets, identifying potential tissue tropisms for 132 viruses.

EpicPCR-Directed Cultivation of a Candidatus Saccharibacteria Symbiont Reveals a Type IV Pili-dependent Epibiotic Lifestyle

This study isolates a CPR bacterium using epicPCR and reveals its type IV pili-dependent epibiotic lifestyle and twitching motility.

Voxelated Bioprinting of Mechanically Robust Multiscale Porous Scaffolds for Pancreatic Islets

This paper introduces a 3D bioprinting technique called DASP to create mechanically robust, multiscale porous scaffolds for encapsulating human pancreatic islets to enable responsive insulin release.

Capture of Viruses and Microorganisms in Aerosols Using A Newly Designed Collection System: A Proof-of-concept Study

The paper introduces a new aerosol collection system with high physical and biochemical capture efficiency for viruses and microorganisms, enabling better disease transmission studies and public health monitoring.

CNS antigen-specific control of early B-lineage development in the meninges

The paper identifies meninges as a site for B cell development and CNS-antigen-specific negative selection in mice and NHPs.

Lipid Bilayer Induces Contraction of the Denatured State Ensemble of a Helical-Bundle Membrane Protein

This study investigates the conformation and dynamics of the denatured state ensemble (DSE) of a membrane protein in a native lipid bilayer, finding it is dynamic and partially expanded.

A novel MRI-based data fusion methodology for efficient, personalised, compliant simulations of aortic haemodynamics

This paper introduces an MRI-based data fusion method for simulating aortic haemodynamics, achieving accurate and efficient patient-specific compliant simulations without CT data.

Fluorescence-Activated Droplet Sorting of Polyethylene terephthalate-degrading Enzymes

This paper develops a fluorescence-activated droplet sorting pipeline to screen for PET-degrading microorganisms and enzymes, identifying new PETase candidates from environmental samples.

Host bioenergetic parameters reveal cytotoxicity of anti-tuberculosis drugs undetected using conventional viability assays.

This study uses extracellular flux analysis to detect anti-tuberculosis drug cytotoxicity in different cell types, revealing effects not captured by conventional viability assays.

Chemoproteomic study uncovers HemK2/KMT9 as a new target for NTMT1 bisubstrate inhibitors

The paper identifies HemK2/KMT9 as a new target of NTMT1 bisubstrate inhibitor NAH-C3-GPKK through chemoproteomic profiling.

Biophysical properties of a tau seed

This study characterizes the biophysical properties of tau seeds, showing they are monomeric and can nucleate tau aggregation in vitro and in cells.

Improving localization precision via restricting biomolecule confined stochastic motion in SMLM

This study investigates stochastic motion of biomolecules in SMLM and shows that restricting this motion improves localization precision.

Recurrent chromosome reshuffling and the evolution of neo-sex chromosomes in parrots

This study identifies recurrent chromosome fusions and gene losses in parrots, revealing the role of transposable elements and genetic drift in neo-sex chromosome evolution.

Comparative Population Genetics in the Human Gut Microbiome

The paper explores comparative population genetics in the human gut microbiome to identify evolutionary trends and functional categories under different selection pressures.

An angiosperm NLR atlas reveals that NLR gene reduction is associated with ecological specialization and signal transduction component deletion

Prediction of occult tumor progression via platelet RNAs in a mouse melanoma model: a potential new platform of cancer screening for early detection of cancer

This paper identifies platelet RNAs that predict occult tumor progression in a mouse melanoma model, showing high diagnostic accuracy for early cancer detection.

High-resolution Cell Atlas of Pig Lung and Online Platform Exploring for Lung Single Cell

The paper generates a single-cell atlas of pig lung using scRNA-seq and develops an online platform to explore lung single-cell data across species.

A comprehensive transcriptome analysis reveals broader but weaker host response of SARS-CoV-2 than SARS-CoV

This study compares the transcriptome responses of SARS-CoV and SARS-CoV-2 in human cell lines, finding broader but weaker host responses for SARS-CoV-2.

Sterilizing immunity against SARS-CoV-2 in hamsters conferred by a novel recombinant subunit vaccine

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.