D. Chen

Identification of four linear B-cell epitopes on the SARS-CoV-2 spike protein able to elicit neutralizing antibodies

The paper identifies four linear B-cell epitopes on the SARS-CoV-2 spike protein that can elicit neutralizing antibodies in multiple species.

Exposure of mammary cells to lipid activates gene expression changes associated with ER-negative breast cancer via chromatin remodeling.

The paper shows lipid exposure alters gene expression and chromatin features in mammary cells, linking these changes to ER-negative breast cancer development.

ORMDL1 is upregulated and associated with favorable outcome in colorectal cancer

This study shows ORMDL1 is upregulated in colorectal cancer and associated with better patient survival.

Spatiotemporal Dynamics of Intra-tumoral Dependence on NEK2-EZH2 Signaling in Glioblastoma Cancer Progression

This study identifies NEK2-EZH2 signaling as critical for glioblastoma tumor core progression and resistance, and presents a novel inhibitor CMP3a that shows therapeutic potential.

Resuscitation of soil microbiota after > 70-years of desiccation

This study assesses bacterial abundance and diversity in 70-year-old desiccated soils, showing significant resuscitation potential and activity of certain taxa after rewetting.

Identification of Cross-Reactive CD8+ T Cell Receptors with High Functional Avidity to a SARS-CoV-2 Immunodominant Epitope and Its Natural Mutant Variants

The paper identifies cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 epitope and its variants, showing their ability to activate and kill infected cells.

Allantoin induces pruritus by activating MrgprD in chronic kidney disease

This study shows allantoin induces pruritus in CKD by activating MrgprD and TRPV1 in DRG neurons.

Diversity and dynamics of fungi during spontaneous fermentations and association with unique aroma profiles in wine

The paper investigates fungal and yeast communities in spontaneous wine fermentations, finding geographic differentiation and S. cerevisiae's role in shaping wine aroma profiles.

Discovery of a Potent and Dual-Selective Bisubstrate Inhibitor for Protein Arginine Methyltransferase 4/5

The paper designs and synthesizes a potent dual-selective bisubstrate inhibitor for PRMT4/5, demonstrating high potency and selectivity with IC50 values of 2.8 nM and <1.5 nM.

Oxidized Lipids and CD36-Mediated Lipid Peroxidation in CD8 T Cells Suppress Anti-Tumor Immune Responses

This study identifies CD36-mediated lipid peroxidation driven by oxidized lipids as a mechanism suppressing anti-tumor CD8 T cell functions in murine tumors.

Distinct effects of different matrix proteoglycans on collagen fibrillogenesis and cell-mediated collagen reorganization

The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

This study shows that CHMP5 regulates bone formation by controlling endolysosome-mitochondrion-mediated cell senescence, and targeting senescent cells can alleviate musculoskeletal abnormalities.

A Multi-Phenotype System to Discover Therapies for Age-Related Dysregulation of the Immune Response to Viral Infections

This paper develops a multi-phenotype system to identify compounds that rejuvenate the immune response in older adults to viral infections, finding disulfiram and triptonide as promising candidates.

Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.

The LTB4-BLT1 signaling axis coordinates actomyosin dynamics and β-2 Integrin trafficking to drive intravascular neutrophil response to infection

This study identifies LTB4-BLT1 signaling and extracellular vesicles as key regulators of neutrophil arrest and extravasation during inflammation.

Dental ontogeny in the most primitive bony fish Lophosteus reveals the developmental relationship between teeth and dermal odontodes

The paper uses synchrotron microtomography to study the ontogeny of teeth and dermal odontodes in Lophosteus superbus, revealing their developmental relationship and shared regulatory mechanisms.

PacC-dependent adaptation and modulation of host cellular pH controls hemibiotrophic invasive growth and disease development by the rice blast fungus

This study identifies the PacC-dependent pH signaling pathway in the rice blast fungus Magnaporthe oryzae, showing it regulates host pH changes and the switch between biotrophic and necrotrophic growth, essential for disease development.

Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

Bridging scales in scattering tissues via multifocal two-photon microscopy

This paper introduces multifocal two-photon microscopy to image mesoscopic scattering tissues at high resolution and speed without tissue-clearing methods.

A Novel System for The Comprehensive Collection of Nonvolatile Molecules from Human Exhaled Breath

This study develops a column system to collect nonvolatile molecules from human exhaled breath with 99% efficiency, identifying 303 proteins linked to lower respiratory airways.

Broad-spectrum antivirals of protoporphyrins inhibit the entry of highly pathogenic emerging viruses

This study identifies a protoporphyrin derivative that inhibits entry of enveloped viruses by targeting viral lipids, showing broad antiviral activity in vitro and in vivo.

Broad and differential animal ACE2 receptor usage by SARS-CoV-2

This study examines ACE2 receptor usage by SARS-CoV-2 across 14 mammalian species, finding broad receptor activity and implications for zoonotic transmission and animal models.

Epigenetic regulator BMI1 promotes fusion-positive rhabdomyosarcoma proliferation and constitutes a novel therapeutic target

This study shows BMI1 promotes FP-RMS proliferation and its inhibition reduces tumor growth and activates the Hippo pathway.

Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogs

This study examines bisubstrate analog interactions with NTMT1 to understand active site plasticity and identifies a 4-C linker analog as the most potent inhibitor.

Selective Peptidomimetic Inhibitors of NTMT1/2: Rational design, synthesis, characterization, and crystallographic studies

This paper designs and characterizes peptidomimetic inhibitors of NTMT1/2, showing high selectivity and cell-permeable activity.

Comparative secretome of Magnaporthe oryzae identified proteins involved in virulence and cell wall integrity

This study compares the secretome of Magnaporthe oryzae wild type and Δalg3 mutants, identifying 51 proteins requiring ALG3 for secretion and showing their roles in virulence and cell wall integrity.

LY6E Restricts the Entry of Human Coronaviruses, including the currently pandemic SARS-CoV-2

This study identifies LY6E as a host protein that restricts entry of human coronaviruses, including SARS-CoV-2, through a mechanism distinct from IFITM3.

PacBio SMRT-based full-length transcriptome data of Ascosphaera apis mycelium and spore

This paper presents full-length transcriptome data of Ascosphaera apis mycelium and spore using PacBio SMRT sequencing, providing high-quality transcripts for genome and transcriptome annotation improvements.

A role for keratins in supporting mitochondrial organization and function in skin keratinocytes

This study shows that keratins K6 and K16 regulate mitochondrial structure, function, and dynamics in keratinocytes, contributing to oxidative stress in pachyonychia congenita.

Integrated profiling of single cell epigenomic and transcriptomic landscape of Parkinson's disease mouse brain

This study profiles single-cell epigenomic and transcriptomic data from Parkinson's disease mouse brain to identify early biomarkers and cellular contributions to disease pathology.