K. Wang

Genomic evolution of non-small cell lung cancer patient-derived xenograft models

This study examines how well PDX models capture intratumour heterogeneity in NSCLC, finding that most models originate from a single subclone but regional models can capture diversity.

Lipoprotein sorting to the cell surface via a crosstalk between the Lpt and Lol pathways during outer membrane biogenesis

The paper identifies lipoproteins transported to the cell surface via LptDE and reveals a crosstalk between Lpt and Lol pathways in Gram-negative bacteria.

The compact CasPi (Cas12l) bracelet "provides" a unique structural platform for DNA manipulation

The paper identifies a new CRISPR-Cas12l system from metagenomes, showing it cleaves DNA with a unique PAM and forms a bracelet structure for gene editing.

Development of a heat-killed fbp1 mutant strain as a therapeutic agent to treat invasive Cryptococcus infection

This paper demonstrates that heat-killed fbp1 mutant cells (HK-fbp1) can protect against lethal Cryptococcus neoformans infection as both a prophylactic vaccine and a therapeutic agent, with T cells mediating protection and early treatment being critical.

Effect of rectified gap junctional electrical coupling and spatial distribution of biologically engineered pacemaking cells on ventricular excitation

This study uses computational models to show that weak-rectified gap junction coupling and electrically isolated distribution of bio-pacemaker cells enhance their pacing efficiency.

Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

Cell type-specific attenuation of brassinosteroid signalling drives stomatal asymmetric cell division

The paper shows that BR signaling is attenuated in stomatal precursor cells but remains active in differentiating epidermal cells, mediated by scaffold proteins.

Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-specific Transcriptome and Molecular Subtype

This study uses deep learning on plasma extracellular vesicle RNA to predict cancer subtypes, monitor treatment effects, and identify gene fusions and neoepitopes without tissue sampling.

The structure, catalytic mechanism, and inhibitor identification of phosphatidylinositol remodeling MBOAT7

This study determines the structure of MBOAT7, models its catalytic mechanism, and identifies potential inhibitors for therapeutic development.

Control of alveolar macrophage differentiation by Siah1a/2 ubiquitin ligases limits carcinogen-induced lung adenocarcinoma

This study shows that Siah1a/2 ubiquitin ligases regulate alveolar macrophage differentiation, and their loss promotes lung adenocarcinoma by increasing immature macrophages and pro-tumorigenic inflammation.

Data Fusion by Matrix Completion for Exposome Target Interaction Prediction

This study introduces a matrix completion method to predict chemical-target interactions, achieving high accuracy and demonstrating its utility for prioritizing environmental chemicals.

Engineering a Single Extracellular Vesicle Protein and RNA Assay (siEVPRA) via In Situ Fluorescence Microscopy in a UV Micropatterned Array

The paper introduces siEVPRA, a method to detect proteins, mRNAs, and miRNAs in single EVs using fluorescence microscopy, showing high sensitivity and clinical utility in GBM samples.

PcoB is a defense outer membrane protein that facilitates cellular uptake of copper

This study characterizes PcoB, an outer membrane protein that facilitates copper import, revealing its structure and function in Cu homeostasis and defense against metal stress.

Clock and riboswitch control of THIC in tandem are essential for appropriate gauging of TDP levels under light/dark cycles in Arabidopsis

Ultra-small bispecific fusion protein augments tumor penetration and treatment efficacy for pancreatic cancer

This paper develops an ultra-small bispecific fusion protein, Bi-fp50, that improves tumor penetration and treatment efficacy for pancreatic cancer by targeting EGFR and VEGF.

Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity

This study shows that mice lacking TG synthesis enzymes in adipose tissue are metabolically healthy and resistant to diet-induced obesity despite reduced TG storage.

A cocktail containing two synergetic antibodies broadly neutralizes SARS-CoV-2 and its variants including Omicron BA.1 and BA.2

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

Ralstonia solanacearum effector RipAF1 ADP-ribosylates host FBN1 to induce resistance against bacterial wilt

This study identifies RipAF1 as an effector that ADP-ribosylates host FBN1, inducing resistance against bacterial wilt by disrupting disease signaling.

Global Spatial Transcriptome of Macaque Brain at Single-Cell Resolution

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

Compact engineered human mechanosensitive transactivation modules enable potent and versatile synthetic transcriptional control

This paper develops compact human mechanosensitive TADs for synthetic transcriptional control, showing they are potent, versatile, and well-tolerated in primary cells.

Structural and functional insight into the plant unique multimodular triphosphosphate tunnel metalloenzymes of Arabidopsis thaliana

This study characterizes the structural and functional properties of two multimodular triphosphosphate tunnel metalloenzymes in Arabidopsis thaliana, revealing their roles in developmental transitions.

Extensive neutralization against SARS-CoV-2 variants elicited by Omicron-specific subunit vaccine booster

This study shows that an Omicron-specific subunit vaccine booster enhances neutralizing antibodies against SARS-CoV-2 variants and the ancestral virus, with a two-dose WT-RBD plus Omicron-RBD booster showing the strongest response.

The exchange rates of amide and arginine guanidinium CEST in the mouse brain

The paper develops a pipeline to measure exchange rates and concentrations of amide and arginine guanidinium protons in the mouse brain using CEST and validates it with specific mouse models.

Structural and functional characterizations of altered infectivity and immune evasion of SARS-CoV-2 Omicron variant

The paper characterizes structural and functional changes in the SARS-CoV-2 Omicron variant's Spike protein, identifying new immune escape sites and providing insights for vaccine development.

A subset of Memory B-derived antibody repertoire from 3-dose vaccinees is ultrapotent against diverse and highly transmissible SARS-CoV-2 variants, including Omicron

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

Reduced infectivity but increased immune escape of the new SARS-CoV-2 variant of concern Omicron

This study assesses the infectivity and immune evasion of the Omicron SARS-CoV-2 variant using pseudotyped viruses and neutralizing assays against convalescent sera and vaccinated individuals.

Histone demethylase UTX regulates glioblastoma progression through affecting periostin expression

This study shows that UTX promotes glioblastoma progression by upregulating periostin expression, and its knockdown inhibits tumor growth and promotes apoptosis.

Ser68 phosphoregulation is essential for CENP-A deposition, centromere function and viability in mice

This study shows that Ser68 phosphorylation is essential for CENP-A deposition, centromere function, and mouse viability.

Chromosome 1q amplification perturbs a ceRNA network to promote melanoma metastasis

The paper shows that chromosome 1q amplification promotes melanoma metastasis by overexpressing ceRNAs that sequester tumor suppressor miRNAs.

Hoxb5 reprograms murine multipotent blood progenitors into hematopoietic stem cell-like cells

This study shows that Hoxb5 can convert multipotent blood progenitors into hematopoietic stem cell-like cells with long-term repopulating ability.