Pain Mechanisms and Treatments

Sex Differences in Bed Nucleus of the Stria Terminalis Response to Calcitonin Gene-Related Peptide

The paper investigates sex differences in CGRP signaling within the BNST and finds that while peptide release is sex-independent, neuromodulation of excitability shows sex-dependent features.

Expression and localization of NMDA receptor GluN2 subunits in dorsal horn pain circuits across sex, species, and late postnatal development

The paper investigates the expression and localization of NMDA receptor GluN2 subunits in dorsal horn pain circuits across sex, species, and development, finding conserved expression but species- and development-specific localization patterns.

Nerve injury triggers nociceptive hypersensitivity with interhemispheric divergence in haplodeficient GAD67-GFP mice

This study shows that GAD67-GFP mice with GABA deficiency develop thermal allodynia after nerve injury, while wildtype mice do not, indicating GABA's role in neuropathic pain.

Inhibition of TYK2 attenuates hyper IL-6- and Oncostatin M-mediated Calcium Signalling in Sensory Neurons

This study shows that inhibiting TYK2 reduces IL-6 and OSM-induced calcium signaling in murine sensory neurons, suggesting therapeutic potential for pain management in IBD.

Addiction-Like Severity Predicts Prolonged Oxycodone Withdrawal-Induced Allodynia in Genetically Diverse Rats

This study shows that higher addiction-like severity in rats predicts prolonged oxycodone withdrawal-induced allodynia, with stronger associations between self-administration behaviors and pain sensitivity.

Spinal-level activation of GPR37 in TRPV1-expressing sensory neurons erases nociceptive system sensitization in murine models

This study shows that activating GPR37 in TRPV1-expressing sensory neurons at the spinal level can reverse long-term pain sensitization in mice.

Moment-to-Moment Pain Variability Predicts Pain Chronification

The paper shows that reduced moment-to-moment pain variability predicts the development of chronic pain from subacute pain.

Chronic neuropathic pain alters reversal learning without generally impacting sucrose self-administration in mice

This study shows chronic neuropathic pain in mice selectively affects reversal learning and pain-reward interactions, with sex-dependent differences, without broadly impairing sucrose self-administration.

Eukaryotic initiation factor 3d Regulates Context-Dependent Pain Hypersensitivity Through the Integrated Stress Response

This study shows that eIF3d modulates pain hypersensitivity under specific stress conditions but not in all pain models.

Satellite microglia-like cells in human dorsal root ganglia and changes with diabetic neuropathy

The paper identifies microglia-like cells in human dorsal root ganglia and shows their changes in diabetic neuropathy.

Layer-specific cortical processing dissociates sensory and cognitive influences on pain

The paper uses high-resolution fMRI to show that sensory and cognitive influences on pain are processed in distinct cortical layers, linking circuit organization to behavioral outcomes.

RGS6 regulates Kappa Opioid Receptor-mediated antinociceptivebehaviors

This study identifies RGS6 as a specific modulator of KOR-dependent anti-nociceptive behaviors and reveals sex-specific effects in pain processing.

Effects of the Mu Opioid Receptor Positive Allosteric Modulator BMS-986122 On Opioid Efficacy in Rat Neuropathic Pain States

This study shows that BMS-986122 enhances low-dose opioid efficacy in rat neuropathic pain models without increasing adverse effects.

T-cell distribution in the dorsal root ganglion across species, sex, and age

The paper investigates T-cell distribution in the dorsal root ganglion across species, sex, and age, finding similar levels in humans, non-human primates, and pigs, but fewer in rats and absent in mice, with sex and age differences in humans.

A novel method to sort and enrich sensory neurons

This study identifies surface markers for isolating sensory neurons and develops a FACS panel for their enrichment without transgenic mice, validated by microscopy and scRNA-seq.

Astrocytic glycogenolysis gates Warburg-like metabolic reprogramming that promotes neuropathic pain chronification

This paper identifies astrocytic glycogenolysis as a metabolic switch that promotes neuropathic pain chronification and shows that inhibiting it reduces pain without impairing acute nociception.

Transcriptomic analysis and high throughput functional characterization of human induced pluripotent stem cell derived sensory neurons

This study develops a novel method to generate human induced pluripotent stem cell-derived sensory neurons that closely resemble primary human tissue transcriptionally and functionally.

Epidermal Langerhans Cells Drive Painful Diabetic Neuropathy in a Sex-dependent Manner

This study identifies epidermal Langerhans cells as key contributors to painful diabetic neuropathy, revealing sex-dependent roles in mechanical allodynia and pain behavior.

Resilience to persistent pain is characterized by stable periodic and increased aperiodic cortical activity

This study shows that cognitive-motor training, like musical expertise, shapes cortical dynamics during pain, leading to more resilient pain responses and improved prediction of pain severity through aperiodic EEG features.

Predicting Pain Using a Data-Driven Agent-Based Model of the Bilateral Central Amygdala

The paper develops a 3D agent-based model of the bilateral central amygdala to predict pain outcomes by integrating neuronal data from CGRPR and PKCδ cells.

Molecular signatures of maladaptive plasticity in the amygdala in a rat model of chronic neuropathic pain

This study identifies molecular changes in the amygdala of rats with chronic neuropathic pain, highlighting oligodendrocyte dysfunction, neuroimmune signaling, and glutamatergic neurotransmission as potential therapeutic targets.

3D Light Sheet Microscopy Reveals Aging Osteoarthritis-associated Joint-innervated Nerve Remodeling in Mouse Knee Joints

This study uses 3D imaging to show that aging male mice with osteoarthritis have increased nociceptive nerve remodeling linked to pain, while females show no age-related changes.

Neuronal EphB2 signaling drives persistent neuropathic pain following spinal cord injury

This study identifies EphB2 signaling in neurons as a mechanism maintaining neuropathic pain after spinal cord injury.

A recurrent neural network model of chronic pain development and recovery

The paper develops a recurrent neural network model to explain chronic pain development and recovery, showing that calming stimuli can reduce pain without pharmacological intervention.

Translational insights into canine dorsal root ganglia cell types using cross-species comparisons

The paper creates a canine dorsal root ganglion cell atlas, identifies cell subtypes, and compares them across species to inform pain research.

Subtype-Resolved Pain-Signaling Architectures Reveal Conserved Drug-Target Interaction Networks in DRG Nociceptors

The paper constructs and compares PPI networks of drug targets in nociceptor subtypes across mouse and human DRGs, revealing species-specific conservation and broader cellular roles of key drug targets.

A Commensal-Derived Lipoteichoic Acid Engages an Inducible Neuronal PD-1 Checkpoint to Suppress Inflammatory Pain

This study identifies a commensal-derived lipoteichoic acid that activates a neuronal PD-1 checkpoint to suppress inflammatory pain through TLR2/6 signaling.

CGRP receptor-expressing neurons in the central amygdala contributes to injury-induced pain hypersensitivity

This study identifies CGRPR-expressing neurons in the central amygdala as key players in pain hypersensitivity, showing their role in both injury-induced and spontaneous pain responses.

Assessments of Evoked and Spontaneous Pain Following Administration of Gabapentin and the Cannabinoid CB2 agonist LY2828360 in a Rat Model of Spared Nerve Injury

This study evaluates the effects of LY2828360, a CB2 agonist, on evoked and spontaneous pain in a rat spared nerve injury model, finding robust suppression of evoked pain but variable results for spontaneous pain assessed via CPP.

Spared nerve injury induces long-term and brain region-specific changes in oligodendrocyte density in mice

This study shows spared nerve injury causes long-term, brain region- and sex-specific changes in oligodendrocyte density in mice, with no effect on oligodendrocyte precursor cells.