Autophagy in Disease and Therapy

Multiple pathways prevent bi-parental mitochondria transmission in C. elegans

The paper investigates genetic factors involved in preventing paternal mitochondria transmission in C. elegans and finds that multiple pathways are required for complete degradation of sperm-derived mitochondria.

Endosomal-lysosomal organellar assembly (ELYSA) structures coordinate lysosomal degradation systems through mammalian oocyte-to-embryo transition

The paper describes endosomal-lysosomal organellar assembly structures in mouse oocytes and their dynamic changes during the oocyte-to-embryo transition.

Chronic lysosome damage boosts interferon responses to Palbociclib dependent upon the mitochondrion

The paper shows chronic lysosome damage from Palbociclib treatment in cancer cells triggers interferon responses via mitochondrial nucleic acid release, dependent on lysosome-mitochondrion contacts.

AURORA: a longitudinal single-cell framework for resolving autophagy-associated remodeling under nutrient stress

AURORA is a longitudinal single-cell framework that analyzes autophagy responses under nutrient stress, revealing cell-line-specific adaptations and shared remodeling programs.

ATG9 vesicles are a subtype of intracellular nanovesicle

The paper identifies ATG9 vesicles as a subtype of intracellular nanovesicles by analyzing their proteome and showing their role in autophagy.

Stathmin 1 regulates mitophagy and cellular function in hematopoietic stem cells

This study shows that Stathmin 1 regulates mitophagy and mitochondrial health in hematopoietic stem cells by maintaining microtubule architecture and autophagy processes.

Oncogenic RAS Induces a Distinctive Form of Non-Canonical Autophagy Mediated by the P38-ULK1-PI4KB Axis

This study identifies RAS-induced non-canonical autophagy mediated by the P38-ULK1-PI4KB axis, showing its role in tumor growth and suggesting therapeutic targeting.

PPTC7 acts as an essential co-factor of the SCFFBXL4 ubiquitin ligase complex to restrict BNIP3/BNIP3L-dependent mitophagy

Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells.

This study shows antigen and cytokines repress autophagy in CD8 T cells, shaping mitochondrial function, migration, and effector machinery through differential proteome pruning.

Melatonin attenuates kidney injury by alleviating lysosomal damage in diabetic kidney disease

This study shows melatonin alleviates lysosomal damage in diabetic kidney disease by upregulating TFEB and the miR-205-5p-LRP-1 pathway, improving autophagy and oxidative stress.

Autophagy suppression in DNA damaged cells occurs through a newly identified p53-proteasome-LC3 axis

The paper identifies a p53-proteasome-LC3 axis that suppresses autophagy in DNA damaged cells, linking p53 stabilization to reduced LC3A/B levels.

The LC3-interacting region of NBR1 is a protein interaction hub enabling optimal flux

This study identifies overlapping SLiMs in NBR1 that mediate interactions with multiple autophagy receptors, revealing cooperative binding mechanisms and the regulatory role of phosphorylation.

ATG8ylation of vacuolar membrane protects plants against cell wall damage

This study identifies a vacuolar quality control pathway in plants that uses ATG8ylation to protect vacuolar integrity following cell wall damage.

SNX10 functions as a modulator of piecemeal mitophagy and mitochondrial bioenergetics

This study identifies SNX10 as a negative regulator of piecemeal mitophagy and mitochondrial bioenergetics, showing its role in modulating mitochondrial homeostasis and cell survival.

Mitophagy at the oocyte-to-zygote transition promotes species immortality

This study identifies MOZT, a mitophagy process at the oocyte-to-zygote transition, which removes damaged mitochondria and preserves mitochondrial health, ensuring species continuity.

The WIPI homolog Atg18 binds to and tethers membranes containing phosphatidylinositol-3,4,5-triphosphate.

This study investigates how Atg18 binds to phosphatidylinositol-3,4,5-triphosphate, showing it clusters membranes and tethers opposing membranes.

REDD1 is a determinant of the sensitivity of renal cell carcinoma cells to autophagy inhibition that can be therapeutically exploited by targeting PIM kinase activity

This paper identifies REDD1 as a key determinant of renal cell carcinoma sensitivity to autophagy inhibition and shows that PIM kinase inhibition enhances this sensitivity through REDD1 upregulation.

Endurance training restores ageing-impaired lysosomal biogenesis factors in rest and response to acute exercise in rat skeletal muscle

This study shows endurance training improves lysosomal biogenesis factors in aged rat skeletal muscle, counteracting age-related sarcopenia and enhancing muscle function.

Combined loss of ATG4B, ATG4C and ATG4D impairs systemic autophagy and triggers accelerated aging in mice

This study shows that loss of ATG4B, ATG4C, and ATG4D in mice causes systemic autophagy defects, leading to accelerated aging and shortened lifespan.

Hyperglycemia worsens smooth muscle foam cell formation through PI3Kgamma-dependent defective autophagy

This study shows hyperglycemia impairs autophagy in smooth muscle cells, promoting foam cell formation via PI3Kgamma and TFEB phosphorylation, suggesting therapeutic potential for PI3Kgamma inhibitors in diabetes-related cardiovascular disease.

Role of N-glycosylation as a determinant of ATG9A conformations and activity

This study uses MD simulations to show that N99 glycosylation in ATG9A enhances protomer interactions and lipid scrambling, but does not significantly affect autophagy flux.

Sex does not Influence Neuronal Autophagy throughout Aging in Mice

The paper examines sex differences in neuronal autophagy across aging in mice and finds no significant sex-related differences in autophagy protein expression or autophagosome formation.

Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity

This study shows that autophagy regulator ATG5 protects cerebellar Purkinje cells by maintaining glycolytic activity, preventing neurodegeneration through regulation of glucose transporter 2.

Kremen1 dependence receptor induces SEC24C- and ATG9A-dependent autophagic cell death

This study shows Kremen1 induces autophagic cell death in cancer cells, dependent on SEC24C and ATG9A, contrasting with typical apoptosis.

New Atg9 phosphorylation sites regulate autophagic trafficking in glia

This study identifies two new Atg9 phosphorylation sites, T62 and T69, that regulate autophagic trafficking in glia and contribute to Parkinson's disease pathology.

Sugar-mediated control of ATG101 modulates carbon deficiency-induced autophagy in Arabidopsis

This study shows that sugar regulates ATG101, a core autophagy initiation complex component, affecting carbon starvation response in Arabidopsis.

Noncanonical activation of Protease-activated receptor 1 induces autophagy in mammalian breast cancer cells

This study shows that noncanonical PAR1 activation by HAP induces autophagy in breast cancer cells, which inhibits tumor growth and delays carcinogenesis in a mouse model.

The RAB27A effector SYTL5 regulates mitophagy and mitochondrial metabolism

This study identifies SYTL5 as a RAB27A effector that regulates mitophagy and mitochondrial metabolism, with reduced expression linked to poor survival in adrenocortical carcinoma.

Mechanistic studies of autophagic cargo recruitment and membrane expansion through in vitro reconstitution

This study uses in vitro reconstitution to investigate ATG8 protein localization and cargo recruitment on phagophore membranes, revealing their roles in membrane expansion and bending.

Non-lytic spread of poliovirus requires the nonstructural protein 3CD

This study identifies a poliovirus nonstructural protein 3CD with an LIR motif critical for non-lytic spread via autophagosome incorporation and trafficking.