Autophagy in Disease and Therapy

CD40 ligation-induced ERK activation promotes autophagy which leads to enhanced radiosensitivity in cervical carcinoma cells

This study shows CD40 ligation increases autophagy via ERK-mediated ATG13 upregulation, enhancing radiosensitivity in cervical cancer cells.

Alterations of PINK1-PRKN signaling in mice during normal aging

This study examines PINK1-PRKN signaling in mice during aging, showing increased gene expression and enzymatic activity in multiple tissues, with the heart showing the most pronounced activation.

Reduced expression of PER2 protein contrbutes to β1-AA induced cardiac autophagy rhythm disorder

This study shows that β1-AA disrupts cardiac autophagy rhythm by reducing PER2 protein expression, which promotes mTORC1 activation and inhibits autophagy in cardiomyocytes.

C. elegans huntingtin, htt-1, promotes robust autophagy induction and survival under stress conditions

This paper shows that C. elegans htt-1 promotes survival under stress by inducing autophagy, with wild-type human HTT rescuing survival defects and mutant HTT worsening them.

Autophagy inhibition induces AML cell death and enhances the efficacy of chemotherapy under hypoxia

This study shows that inhibiting autophagy with Lys05 enhances AML cell death and chemotherapy efficacy under hypoxia.

Phagolysosomes break down the membrane of a non-apoptotic corpse independent of macroautophagy

The paper shows that macroautophagy is not required for polar body degradation in C. elegans embryos, highlighting a distinct mechanism for corpse clearance.

NF-kappaB and JNK pathways mediate metabolic adaptation upon ESCRT-I deficiency

This study shows that ESCRT-I deficiency leads to metabolic reprogramming via NF-kappaB and JNK pathways, causing increased glycolysis and lipid accumulation.

Small molecule modulator of neuronal lysosome positioning and function resolves Alzheimers Disease-linked pathologies in cultured human neurons

A small molecule modulates neuronal lysosome positioning and function, reducing amyloid-beta levels and rescuing pathologies in human neurons and zebrafish.

Peptide modified, programmable DNA tetrahedra to modulate autophagy in biological systems

This paper introduces a DNA tetrahedron-BH3 peptide nanosystem that selectively induces autophagy by disrupting Beclin 1-Bcl2 interaction, showing reduced ROS and no apoptosis in HeLa cells and zebrafish larvae.

Secretory Autophagy via VMP1-Containing Extracellular Vesicles in Pancreatic Stress Responses

The paper shows VMP1 drives secretory autophagy via extracellular vesicles in pancreatic stress responses, with increased VMP1 secretion under stress conditions.

A Novel Human TBCK- Neuronal Cell Model Results in Severe Neurodegeneration and Partial Rescue with Mitochondrial Fission Inhibition

The paper establishes a human cell model for TBCK syndrome, showing mitochondrial dysfunction and partial rescue with a fission inhibitor.

Mitophagy modulation rescues single large-scale mitochondrial DNA deletion (SLSMD) disease symptoms in the C. elegans uaDf5 animal model.

This study identifies therapeutic candidates for SLSMD diseases by screening mitophagy modulators in a C. elegans model, showing that Celastrol reduces mitochondrial stress and improves health outcomes.

Mechanism of TAX1BP1 recruitment in aggrephagy to switch from cargo collection to sequestration

The paper investigates how TAX1BP1 recruits the autophagy machinery to switch from cargo collection to sequestration in aggrephagy.

AMPK activation promotes transcriptional activation of TFEB through its dephosphorylation

The paper shows that AMPK activation leads to dephosphorylation of TFEB's C-terminal sites, promoting its transcriptional activation, and that AMPK is not required for mTORC1-mediated TFEB activation.

ATG5 is dispensable for ATG8ylation of cellular proteins

The paper investigates the mechanism of protein ATG8ylation, showing that ATG5 is dispensable for this process, unlike its role in lipid ATG8ylation.

Autophagy alterations in white and brown adipose tissues of mice exercised under different training protocols

This study examines how different exercise protocols affect autophagy in white and brown adipose tissues of mice, revealing protocol- and tissue-specific changes in autophagy markers.

Zebrafish reveal new roles for Fam83f in hatching and the DNA damage-mediated autophagic response

This study generates fam83f knock-out zebrafish to investigate Fam83f's role in hatching and DNA damage response, finding impaired autophagy and increased radiation sensitivity.

The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy

The paper identifies the triad interaction between ULK1, ATG13, and FIP200 as essential for ULK complex formation and autophagy initiation.

Phospholipase D3 regulates lysosomal morphology, biogenesis, and function in neurons.

This study shows PLD3 regulates lysosomal morphology, biogenesis, and function in neurons by affecting protein abundance, subcellular location, and clearance of aggregated proteins.

TDRD3 functions as a selective autophagy receptor with dual roles in autophagy and modulation of stress granule stability

This paper identifies TDRD3 as a selective autophagy receptor with roles in autophagy and stress granule stability, showing its structural similarity to p62/SQSTM1 and functional impact on viral replication.

Methods for detection of cardiac glycogen-autophagy

The paper develops methods to detect glycophagy in cardiac cells using antibodies and fluorescent markers to measure lysosomal flux and glycogen accumulation.

Enhancing lysosome function via mTOR/TFEB activation reduces lipofuscin-like granules in early Age-related Macular Degeneration

This study shows that activating the mTOR/TFEB pathway reduces lipofuscin-like granules in AMD by improving lysosomal function and POS digestion.

SARS-CoV-2 Protein ORF3a Drives Lysosomal Membrane Atg8ylation

This study shows that SARS-CoV-2's ORF3a protein induces lysosomal membrane atg8ylation, which protects cells from death by limiting ORF3a-induced cell death.

Identification and Validation of Mitophagy-Related Genes in Diabetic Retinopathy

The paper identifies and validates mitophagy-related genes in diabetic retinopathy using bioinformatics and experimental validation.

Presynapses are mitophagy pit stops that prevent axon degeneration

The paper identifies presynapses as sites of mitophagy in neurons and shows their role in preventing axon degeneration when mitophagy is defective.

Neuronal autophagosomes are transported to astrocytes for degradation

The paper identifies a novel pathway where astrocytes clear pre-synaptic autophagosomes from neurons through a cholesterol-dependent endocytosis process without requiring direct cell contact or retrograde transport.

Fc immunoreceptors promote autophagy to regulate monocyte functions

This study shows that Fc receptors trigger autophagy, which modulates monocyte functions like cytokine production and phagocytosis.

Autophagy-dependent proteome remodelling and ribosome decline balance starvation survival and recovery speed in C. elegans

This study shows that autophagy-dependent loss of ribosomal proteins during starvation in C. elegans balances survival and recovery speed by affecting growth resumption.

Selective autophagy fine-tunes Stat92E activity by degrading Su(var)2-10/PIAS during glial injury signalling in Drosophila

The paper shows that autophagy degrades Su(var)2-10/PIAS to activate Stat92E in Drosophila glial cells during injury, enhancing glial reactivity and innate immune responses.

BCL2L13 Influences Autophagy and Ceramide Metabolism without Affecting Temozolomide Resistance in Glioblastoma

This study identifies BCL2L13 as a regulator of autophagy and ceramide metabolism in glioblastoma, showing distinct effects on metabolic pathways in TMZ-resistant and sensitive cells.