Genetics, Aging, and Longevity in Model Organisms

The murine transcriptome reveals global aging nodes with organ-specific phase and amplitude

The paper analyzes aging dynamics across 17 organs and plasma proteomics in mice, revealing consistent gene expression trajectories with organ-specific timing and amplitude.

Repair, resilience and asymmetric segregation of damage in the context of replicative ageing: it is a balancing act

The paper develops a dynamic model of damage accumulation in yeast cells to understand how damage retention and asymmetric division affect replicative ageing.

Universal transcriptomic signature of age reveals temporal scaling of Caenorhabditis elegans aging trajectories

The paper identifies a universal transcriptomic signature of aging in C. elegans and shows it can predict lifespan extension and drug effects.

Inhibition of GMP synthesis extends yeast replicative lifespan

This study shows that inhibiting GMP synthesis extends yeast replicative lifespan through a mechanism independent of known nutrient-sensing and sirtuin pathways.

Drosophila egg-derived tyrosine phosphatase (EDTP): a novel target for improved survivorship to prolonged anoxia and cellular protein aggregates

This paper shows that reducing EDTP/MTMR14 in specific tissues improves survivorship to anoxia and protein aggregates in Drosophila and mice.

Effects of sugars and lipids on the growth and development of Caenorhabditis elegans

This study examines the effects of sugars and lipids on C. elegans growth, finding that excessive intake reduces lifespan, reproductive capacity, and body length while altering gene expression.

Senescent cells and the dynamics of aging

The paper combines theory and experiments in mice to show that senescent cells have a rapid turnover that saturates with age, leading to persistent differences in cell accumulation and explaining demographic mortality laws.

Integration of heterogeneous functional genomics data in gerontology research identifies genes and pathway underlying aging across species

The paper integrates heterogeneous functional genomics data across species to identify genes and pathways underlying aging, finding Cd63 as a key gene with lifespan-extending effects in C. elegans.

Ferrous-glutathione coupling mediates ferroptosis and frailty in Caenorhabditis elegans

This study shows that ferrous-glutathione coupling promotes ferroptosis and frailty in C. elegans, and blocking ferroptosis extends lifespan and healthspan.

HSB-1 inhibition and HSF-1 overexpression trigger overlapping transcriptional changes to promote longevity in Caenorhabditis elegans

The paper shows that inhibiting HSB-1 and overexpressing HSF-1 in C. elegans lead to overlapping transcriptional changes that promote longevity.

Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion

This study shows glycine supplementation extends C. elegans lifespan and alters gene expression, with effects dependent on the methionine cycle.

Experimentally reduced insulin/IGF-1 signalling in adulthood extends lifespan of parents and improves Darwinian fitness of their offspring

This study shows reducing insulin/IGF-1 signaling in adult C. elegans extends parental lifespan and improves offspring fitness, supporting the hyperfunction theory of aging.

Two stochastic processes shape diverse senescence patterns in a single-cell organism

The paper shows that senescence in Escherichia coli is shaped by two stochastic processes: random cellular deterioration and asymmetric transmission of an unknown factor during cell division.

Deep behavioural phenotyping reveals divergent trajectories of ageing and quantifies health state in C. elegans

This study uses multi-parametric phenotyping to analyze ageing trajectories in C. elegans, revealing divergent ageing patterns in disease models and quantifying health states through phenotypic flexibility.

Epicatechin modulates stress-resistance in C. elegans via Insulin/IGF-1 signaling pathway

This study shows that epicatechin enhances stress resistance in C. elegans by modulating the insulin/IGF-1 signaling pathway.

RiboTag translatomic profiling of Drosophila oenocytes under aging and oxidative stress

This study uses RiboTag sequencing to analyze the translatome of Drosophila oenocytes under aging and oxidative stress, identifying shared molecular mechanisms with mammalian liver aging.

Using the drug-protein interactome to identify anti-ageing compounds for humans

The paper identifies anti-ageing drug candidates by analyzing drug-protein interactions and validates one candidate in C. elegans.

Higher transcriptome stability during aging in long-lived giant mole-rats compared to short-lived rats

This study compares transcriptome stability during aging between long-lived giant mole-rats and short-lived rats, finding greater stability in mole-rats.

C. elegans granulins promote an age-associated decline in protein homeostasis via lysosomal protease inhibition

This study identifies granulins as regulators of lysosomal protease activity in C. elegans, showing their role in age-related protein homeostasis decline.

Pervasive positive and negative feedback regulation of insulin like signaling in Caenorhabditis elegans

The paper investigates feedback regulation in the C. elegans insulin-like signaling network during state transitions, revealing widespread positive and negative feedback mechanisms.

Inter-generational Consequences for Growing C. elegans in Liquid

This study shows that growing C. elegans in liquid media leads to intergenerational changes in size, which are not fully reversible and may involve epigenetic mechanisms.

Molecular inflection points in the aging human brain

The paper identifies inflection points in age-related gene expression in human brain tissues and microglia, suggesting they may mark critical transitions in aging and neurodegenerative disease onset.

Shortened lifespan and other age-related defects in bang sensitive mutants of Drosophila melanogaster

The paper examines age-related defects in Drosophila melanogaster bang sensitive mutants, finding that some exhibit shortened lifespan and impaired motor function, which can be partially rescued by melatonin.

The Miniature-chemostat Aging Device: A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of replicatively aging yeast

The paper introduces a new platform to study aging yeast by purifying old cells and analyzing their transcriptional and chromatin changes.

jouvence, a new small nucleolar RNA required in the gut extends lifespan in Drosophila

This paper identifies a new Drosophila snoRNA, jouvence, that extends lifespan when overexpressed and reduces it when lost, suggesting a role in transcriptional control and evolutionary conservation.

A family of transcription factors that limit lifespan: ETS factors have conserved roles in longevity

This study identifies ETS transcription factors as conserved regulators of longevity across species, showing their roles in modulating lifespan through gene expression programs.

Royalactin induces copious longevity via increased translation and proteasome activity in C. elegans.

This study shows royalactin extends C. elegans lifespan by increasing protein translation and proteasome activity, suggesting a new mechanism for longevity.

A functional study of all 40 C. elegans insulin-like peptides

This study overexpresses all 40 C. elegans insulin-like peptides to identify their functions, categorizing 35 as agonists, antagonists, or pleiotropic, and linking peptide structure to function.

Acute effects of drugs on C. elegans movement reveal complex responses and plasticity

The paper examines acute drug effects on C. elegans movement, revealing complex recovery phases and drug-specific responses that highlight biological network plasticity.

Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging.

The paper compares liver proteomes of long-lived naked mole-rats and short-lived guinea pigs to identify molecular networks linked to longevity and human aging.