Genetics, Aging, and Longevity in Model Organisms

Translational control of methionine and serine metabolic pathways underpin the paralog-specific phenotypes of Rpl22 ribosomal protein mutants in cell division and replicative longevity

The paper identifies translational control of methionine and serine metabolic pathways as the mechanism underlying paralog-specific phenotypes in Rpl22 ribosomal protein mutants, linking these changes to cell division and replicative longevity.

Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver

The paper shows that somatic mutation frequencies increase with age in human liver hepatocytes but are lower in liver stem cells and organoids.

Diverse biological processes coordinate the transcriptional response to nutritional changes in a Drosophila melanogaster multiparent population

The paper identifies diet-induced gene expression variation in Drosophila melanogaster using RNA-seq, revealing diverse pathways beyond the insulin/TOR pathway.

Celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish.

This study identifies celsr1a as essential for tissue homeostasis and aging onset in zebrafish, showing its role in maintaining progenitor cells and that caloric restriction can mitigate its effects.

Loss of vacuolar acidity results in iron sulfur cluster defects and divergent homeostatic responses during aging in Saccharomyces cerevisiae

The paper shows that loss of vacuolar acidity in yeast causes iron sulfur cluster defects and divergent iron homeostasis during aging.

Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules that Affect Aging Pathways and Extend C. elegans Lifespan

The paper screens 100,000 small molecules in human fibroblasts to find those increasing oxidative stress resistance and extending C. elegans lifespan.

Prolonged quiescence delays somatic stem cell-like division in Caenorhabditis elegans and is controlled by insulin signalling

This study shows prolonged quiescence in C. elegans L1 larvae delays cell division and is regulated by insulin signaling, with maternal age affecting recovery variability.

A genome-wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells

The paper identifies genes that suppress spontaneous mutation accumulation in yeast cells, finding PEX19 as an age-specific mutation suppressor.

H3K9me2 protects lifespan against the transgenerational burden of germline transcription in C. elegans

The paper shows that H3K9me2 protects lifespan in C. elegans by counteracting the transgenerational effects of germline transcription.

Transcription-induced formation of extrachromosomal DNA during yeast ageing

This study shows that transcription of the CUP1 gene in aged yeast leads to the formation of extrachromosomal DNA, which accumulates without phenotypic selection and is site-specific.

Undulating changes in human plasma proteome across lifespan are linked to disease

Profiling 2,925 plasma proteins in 4,331 people aged 18-95 reveals non-linear aging: protein waves crest at 34, 60 and 78 years, later waves overlapping disease proteomes.

Escherichia coli Metabolite Profiling Leads to the Development of an RNA Interference Strain for Caenorhabditis elegans

The paper identifies specific bacterial metabolites affecting C. elegans physiology and develops an RNA interference strain to study genotype-phenotype interactions without microbial confounding.

Swim exercise in C. elegans extends neuromuscular and intestinal healthspan, enhances learning ability, and protects against neurodegeneration

This study shows that swim exercise in C. elegans improves healthspan and protects against neurodegeneration, even when exercise stops early in adulthood.

Pluronic gel-based burrowing assay for rapid assessment of neuromuscular health in C. elegans

This paper introduces a Pluronic gel-based burrowing assay to assess neuromuscular health in C. elegans by measuring their ability to navigate a gel environment.

A novel approach of human geroprotector discovery by targeting the converging subnetworks of aging and age-related diseases

This paper introduces ANDRU, a human data-driven approach to discover geroprotectors by targeting aging and age-related disease subnetworks, identifying potential targets and compounds in adipose and artery tissues.

Expression of heat shock protein 70 is insufficient to extend Drosophila melanogaster longevity

This study shows that overexpressing hsp70 in Drosophila melanogaster does not extend longevity or stress resistance, except for a reduction in male lifespan with ubiquitous expression.

Developmental Reactive Oxygen Species Target Histone Methylation to Individualize Stress resistance and Lifespan

The paper shows that early developmental ROS increases stress resistance and lifespan by reducing histone H3K4me3 levels in C. elegans and mammalian cells.

Understanding biological ageing in terms of constitutive signals: Convergence to an average decrease in cellular sensitivity and information transmission

The paper argues that biological ageing involves a decrease in cellular sensitivity and information transmission due to accumulated damage, leading to increased noise in biological networks.

Age-related Gene Expression Signatures (AGES) in rats demonstrate early, late, and linear transcriptional changes from multiple tissues

The paper identifies age-related gene expression patterns in multiple rat tissues, revealing early, mid, late, and linear transcriptional changes and their potential pharmacological targets.

Population selection and sequencing of C. elegans wild isolates identifies a region on chromosome III affecting starvation resistance

Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans

Age-related decline in metabolite heavy isotope content in rodent organs

The paper shows age-related decline in heavy isotope content in mouse tissues, suggesting a potential link to aging and healthspan extension.

Biomarkers for aging identified in cross-sectional studies tend to be non-causative

This study shows cross-sectional aging biomarker studies are biased toward non-causal factors, but this bias can be corrected using mortality correlates from longitudinal studies.

LFASS: Label-Free Automated Survival Scoring for High-Throughput Nematode Assays

The paper introduces a label-free automated method to score nematode survival in high-throughput assays and finds an autophagy-dependent increase in acute stress resistance in early adulthood.

Stochastic modeling of aging cells reveals how damage accumulation, repair, and cell-division asymmetry affect clonal senescence and population fitness

The paper models aging cells to show that damage accumulation and repair rates are key to fitness and clonal senescence, while division asymmetry has minimal impact.

Astaxanthin extends lifespan via altered biogenesis of the mitochondrial respiratory chain complex III

This study shows astaxanthin extends C. elegans lifespan by altering mitochondrial complex III biogenesis, with cross-species effects on oxidative phosphorylation.

Cross-species functional modules link proteostasis to human normal aging

The paper identifies evolutionarily conserved functional modules related to proteostasis in normal aging across species and links them to age-related GWAS and caloric restriction.

Translational regulation of non-autonomous mitochondrial stress response promotes longevity

The paper identifies translational repression of CYC-2.1 in the germline as a mechanism that extends lifespan through non-autonomous activation of UPRmt and AMPK in C. elegans.

Dietary restriction induces post-transcriptional regulation of longevity genes.

This study identifies post-transcriptional mechanisms regulating longevity in C. elegans under dietary restriction, highlighting roles for RNA binding proteins, microRNA, and nonsense mediated decay.

Forward genetic screen for Caenorhabditis elegans mutants with a shortened locomotor healthspan

The paper identifies C. elegans mutants with shortened locomotor healthspan, finding that Elongator complex mutations impair adult locomotor function.