Cell Adhesion Molecules Research

Endothelial Heterogeneity Across Vascular Beds Impacts Inflammatory Signaling and Neutrophil Adhesion

This study examines how endothelial cell heterogeneity across vascular beds affects inflammatory signaling and neutrophil adhesion through experimental analysis and statistical modeling.

Fasciclin 2 Cooperates with Discs Large to Maintain Epithelial Architecture

This study shows Fasciclin 2 (Fas2) supports epithelial reintegration through two modes, with Discs large (Dlg1) stabilizing the cortical Fas2 pool.

Insulin-Like Growth Factor 1 Receptor Regulates Breast Cancer Cell Adhesion through Beta-1 Integrin

This study shows that IGF1R regulates breast cancer cell adhesion through β1 integrin, with both IGF-1 stimulation and IGF1R knockdown increasing adhesion by removing IGF1R from the cell surface.

Structural basis for the intestinal protocadherin-based intermicrovillar adhesion complex

The paper determines the Cryo-EM structure of the intestinal IMAC complex, revealing its heterotetrameric composition and structural features that enable microvilli adhesion and resilience to shear stress.

ILK binding to β1 Integrin is indirectly mediated by Kindlin-2

This study resolves the debate on how ILK binds to β1 integrin by showing ILK is recruited via K2, not directly, using interdisciplinary methods.

E- and N-cadherin drive hepatic polarity and lumen elongation via opposing effects on RhoA activity

This study shows E- and N-cadherin regulate hepatic polarity and bile canaliculi formation through opposing effects on RhoA activity.

From Generalist to Specialist: Evolution of PS2 α-integrins and Implications for Drug Targeting

The paper analyzes the evolutionary history of PS2-integrins across vertebrates to identify lineage-specific functional divergence and inform drug targeting strategies.

Regulation of reticular adhesions by KANK2 and talin2 in two melanoma cell lines

This study identifies KANK2 and talin2 in reticular adhesions of melanoma cell lines and shows their differential roles in RA composition.

Crosstalk between Echinoid and Sidekick, two IgCAM proteins, modulates Adherens Junction dynamics and tissue remodelling

This study investigates the functional relationship between Echinoid and Sidekick, two IgCAM proteins, showing they modulate Adherens Junction dynamics and tissue remodelling through bidirectional interactions and shared intracellular adaptors.

Oncogenic RAS-driven α2 integrin induction under nutrient stress promotes cancer cell motility

This study shows that nutrient stress increases α2 integrin expression via RAS/MAPK and mTOR pathways, enhancing cancer cell motility and correlating with poor pancreatic cancer prognosis.

SNED1 modulates ECM architecture and cell proliferation via LDV-binding integrins

This study shows that SNED1 interacts with LDV-binding integrins to remodel the ECM, align cells, and promote proliferation, crucial for neural crest migration and cancer invasion.

KANK2 at focal adhesion regulates their maintenance and dynamics, while at fibrillar adhesions it influences cell migration via microtubule-dependent mechanism

This study shows KANK2 has distinct roles in focal adhesions and fibrillar adhesions, regulating their maintenance and cell migration via microtubule interactions.

Orphan GPR84 facilitates uropod de-adhesion to terminate leukocyte diapedesis during inflammation

This study identifies GPR84 as a regulator of immune cell extravasation by enabling uropod de-adhesion during inflammation, showing its role in terminating leukocyte migration.

An Aggregation Prone Region (APR) in talin controls talin self-interactions to regulate integrin adhesion complex dynamics

This paper identifies an aggregation-prone region in talin that drives self-interactions and regulates integrin adhesion complex dynamics through mechanical unfolding and oligomerization.

Regulated RIAM-Talin Engagement Controls Adhesion Stability and Mechanical Output

This study shows that sustained RIAM-talin engagement reprograms adhesion dynamics and force transmission, with Rap1 playing a separable role in adhesion turnover and traction force generation.

A flow cytometry-based assay to quantify the binding of transmembrane ligands to their cognate receptors using fluorescent virus-like particles

This paper introduces a flow cytometry-based assay using fluorescent virus-like particles to quantify transmembrane ligand-receptor binding, showing it can study patient-derived variants and enable single-cell analysis of multiple interactions.

Bivalency of natalizumab promotes inhibition of dynamic VLA-4 adhesion beyond affinity gain

This study shows that bivalent natalizumab inhibits VLA-4 adhesion more effectively than monovalent Fab fragments under shear stress, suggesting kinetic and geometric factors are critical for therapeutic efficacy.

Two δ-Catenins, Plakophilin 4 and p120, Promote Formation of Distinct Types of Adherens Junctions

This study identifies how p120 and plakophilin 4 regulate distinct adherens junction types through different cadherin clustering mechanisms in epithelial cells.

Tetraspanin CD82 reduces the formation of CADM1 oligomers

This study shows CD82 reduces CADM1 oligomer formation by interacting with its extracellular domains, affecting transmembrane helix spacing and disrupting cell adhesion.

Load-dependent RGD-context sensing via αV-class integrins reprograms cellular adhesion and mechanics within seconds

This study reveals how V-class integrins rapidly sense RGD motifs and reprogram cell adhesion and mechanics through distinct mechanotransduction pathways.

Pancreatic cancer metastasis is regulated by an eleven amino-acid sequence

This study identifies an 11-amino-acid sequence in the integrin β6 subunit that regulates pancreatic cancer metastasis by affecting cell proliferation, migration, and invasion.

FCHo2, instead of talin, enables inside-out activation of integrin αvβ5 in curved adhesions

This paper identifies FCHo2 as a curvature-sensing protein that enables inside-out activation of integrin αvβ5 in curved adhesions, distinct from talin's role in focal adhesions.

Integrin α5β1 mediates the inhibitory effects of vasoinhibin on angiogenesis and vascular permeability

This study identifies integrin α5β1 as the receptor for vasoinhibin's HGR motif, revealing its role in inhibiting angiogenesis and vascular permeability through integrin activation.

NaBC1 Acts as a Mechanosensitive Co-regulator of Fibronectin-binding Integrins Adhesion and Myoblast Polarization

This study shows NaBC1 enhances myoblast adhesion and polarization by interacting with fibronectin-binding integrins and modulating mechanotransduction.

The β integrin modulates serotonin sensitivity via NPxY motifs to regulate egg laying and mechanosensation behaviors in C. elegans

This study shows that NPxY motifs in C. elegans pat-3 β integrin modulate serotonin sensitivity and mechanosensation by affecting vulval contraction and neurotransmitter levels.

Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics

The paper identifies the CD9 interactome in epithelial cells during bacterial infection, showing species-specific interactions and demonstrating a CD9-derived peptide can block bacterial adherence.

Optogenetic construction of de novo integrin-adhesion complexes reveals role for biocondensation in adhesion nucleation

This paper uses optogenetics to test how talin's activity and phase states influence integrin-adhesion complex (IAC) nucleation and stabilization, finding that biocondensation enables adhesion formation even without extracellular matrix.

P-cadherin and desmoglein-2 interact as strand-swap dimers and facilitate desmosome assembly.

This study identifies how P-cadherin and Desmoglein-2 form strand-swap dimers to facilitate desmosome assembly through structural and functional analyses.

Mixed-mobility supported lipid bilayers reveal the modulatory role ofimmobilized ICAM1 on T cell activation, effector functions and immune synapse organization

Evolutionary origin and structural ligand mimicry by the inserted domain of alpha-integrin proteins

The paper investigates the evolutionary origin and structural role of the I domain in integrin proteins, showing it mimics ligands to enable activation and expand cellular communication.