Lipid metabolism and biosynthesis

Comparative genomics of the lipid droplet-associated protein Seipin across eukaryotic diversity illuminates an ancient origin and conserved structural diversity.

The paper examines the evolutionary history of seipin across eukaryotes, finding it conserved in the Last Eukaryotic Common Ancestor and highlighting functional divergence between yeast and human seipin.

Dynamics of Fanconi anemia protein D2 in association with nuclear lipid droplet formation

This study shows FANCD2 interacts with lipid metabolism factors and localizes to nuclear lipid droplets, independent of its role in DNA repair.

Lipid Landscape of human cells

The paper maps lipid species across human cell compartments using PAP-SL and identifies general rules of lipid organization and metabolic plasticity.

Phosphatidylserine and RhoB connect phosphatidylinositol 4-phosphate and phosphatidic acid metabolism at the plasma membrane

The paper identifies a metabolic connection between PI4P and PA at the plasma membrane, showing how PI4P depletion increases PA levels through PS synthesis and RhoB activation.

Lipid droplet dynamics during the budding yeast cell cycle influence the timing of cell cycle START

The paper investigates lipid droplet dynamics during the budding yeast cell cycle and finds that their oscillation influences the timing of cell cycle START.

Steric Repulsion Counteracts ER-to-Lipid Droplet Protein Movement

The paper identifies steric repulsion as a mechanism regulating ER-to-LD protein movement, showing high-affinity proteins exclude lower-affinity ones during adipocyte differentiation.

Bifunctional probes reveal the rules of intracellular ether lipid transport

The paper introduces bifunctional ether lipid probes to study intracellular transport kinetics and identifies differences in transport rates between alkyl- and vinyl-linked ether lipids.

Identification and characterization of the delta-12 fatty acid desaturase from Euglena gracilis

This study identifies and characterizes the delta-12 fatty acid desaturase in Euglena gracilis, showing its role in linoleic acid production through heterologous expression and CRISPR knockout.

Neutral lipid processing in glia is sexually dimorphic and promotes sleep through diacylglycerol catabolism

The paper identifies sex-specific lipid differences in Drosophila neurons and glia and links glial diacylglycerol catabolism to sleep promotion.

ACAD10 encodes two orphan enzymes in the ether lipid biosynthetic and salvage pathways

This study identifies ACAD10 as encoding two enzymes involved in ether lipid biosynthesis and salvage, linking them to type 2 diabetes risk.

Kidney-specific lipid metabolism underlies stable chemical individuality in domestic cats and other felids

The paper identifies unique lipid droplets in felid kidneys that serve as stable chemical signatures for individual recognition through olfactory cues.

A partner switch from CDS2 to RAB1A redirects MBOAT7 to inhibit DGAT2-mediated lipid droplet growth

The paper shows MBOAT7 redistributes to ER-LD contacts via RAB1 to inhibit DGAT2-mediated lipid droplet growth in response to CDS2 disruption.

Quantitative imaging of species-specific lipid transport in mammalian cells

The paper quantifies lipid transport between organelles in mammalian cells, revealing non-vesicular transport as a key mechanism for species-specific lipid sorting.

A Suite of Stains: Characterization of four fluorophores as complementary tools for visualizing neutral lipids in an extremophilic green alga

The paper evaluates four fluorophores for visualizing lipid droplets in an extremophilic green alga, finding that Cou and DPAS offer strong specificity and low toxicity, while BODIPY and DAF have distinct limitations.

Setaphyte VERY-LONG-CHAIN FATTY ACYL DESATURASES are desaturases that impact glycerolipid and sphingolipid metabolism

The paper characterizes SFDs in setaphytes, showing they desaturate VLCFAs in sphingolipids and glycerolipids, likely via acyl-CoA substrates, and suggests renaming them VFADs.

Mechanism for oil-phase separation by the lipid droplet assembly complex

The paper demonstrates that the lipid droplet assembly complex (LDAC) catalyzes oil-phase formation in membranes, enabling organized lipid droplet formation.

Protein characterization of the soybean malic enzyme family to select metabolic targets for seed oil improvement

This study characterizes soybean malic enzyme isoforms to identify metabolic targets for improving seed oil content.

Corylus avellana non-specific lipid-transfer protein Cor a 8 is a moonlighting enzyme with a new lipase activity

This study identifies Cor a 8, a non-specific lipid-transfer protein, as a novel lipase in hazelnuts that hydrolyzes triglycerides and contributes to lipid oxidation.

SUMO proteases SPF1/2 inhibit seed filling and fatty acid biosynthesis by deSUMOylating WRI1

This study identifies SPF1/2 SUMO proteases that inhibit seed filling and fatty acid biosynthesis by deSUMOylating WRI1, enhancing its degradation and reducing oil accumulation in Arabidopsis.

Resolving cofactor imbalance in triacylglycerol biosynthesis in oilseeds through glycolytic shunts: a modeling study

This study uses metabolic modeling to show that glycolytic shunts correct cofactor imbalance in triacylglycerol biosynthesis, enabling higher biosynthetic rates in oilseeds.

A dominant CIDEC variant segregates with familial obesity by increasing lipid droplet size in adipocytes

This study identifies a dominant CIDEC variant causing familial obesity by increasing lipid droplet size in adipocytes through structural and functional changes.

Small molecule promoters of endogenous lipid droplet accumulation drive lysophagy

The paper identifies small molecules that promote lipid droplet accumulation, which induces lysophagy and inhibits cancer cell proliferation.

Role of Chloroplast Lipid-Remodelling Protein 23 During Cold Acclimation in Arabidopsis thaliana

This study investigates the role of CLRP23 in cold acclimation of Arabidopsis thaliana, showing its involvement in lipid remodeling and integration of membrane and metabolic responses.

The lipid droplet protein Jabba promotes actin remodeling downstream of prostaglandin signaling during Drosophila oogenesis

The paper identifies Jabba as a downstream effector of prostaglandin signaling that promotes actin remodeling during Drosophila oogenesis, revealing two distinct PG-dependent pathways for actin remodeling.

Designing new natural-mimetic phosphatidic acid: aversatile and innovative synthetic strategy forglycerophospholipid research

This paper introduces a new synthetic strategy for phosphatidic acid analogues that preserves acyl chain structure and enables flexible molecular grafting for biological studies.

Functional study of Phaeodactylum tricornutum Seipin homolog highlights unique features of lipid droplets biogenesis in diatoms.

This study functionally characterizes PtSeipin in Phaeodactylum tricornutum, revealing unique lipid droplet biogenesis mechanisms in diatoms and highlighting its role in TAG accumulation under stress.

The growth-promoting protein TMEM263 is an ER resident that controls early stages of lipid droplet biogenesis

This study identifies TMEM263 as an ER-resident protein essential for lipid droplet formation and growth, showing its role in lipid condensation and organismal development.

PI(4)P recruits CIDE proteins to promote the formation of unilocular lipid droplets during adipogenesis and hepatic steatosis

The paper shows PI(4)P recruits CIDE proteins to form unilocular lipid droplets in adipogenesis and hepatic steatosis by interacting with ORP2/5 and PI4K2A.

FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses

This study identifies FAF2 as a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses through a CRISPR knockout screen in human cells.

Gcn4 regulates phospholipid methylation and SAM dependent methyl allocations between phospholipids and histones during methionine-supplemented growth

This study shows that Gcn4 regulates SAM allocation between phospholipid and histone methylation during methionine-supplemented growth in yeast.