Lipid metabolism and biosynthesis

Nvj3 regulates Dga1-mediated triacylglycerol synthesis and lipid droplet formation at ER contact sites

This study identifies Nvj3 as a regulator that links diacylglycerol availability to triacylglycerol synthesis and lipid droplet formation at ER contact sites during metabolic stress.

Dynamic network regulating phosphatidic acid homeostasis revealed using membrane editing coupled to proximity labeling

The paper develops a 'Feeding-Fishing' approach to study phosphatidic acid homeostasis by combining membrane editing and proximity labeling, identifying key enzymes and lipid transfer proteins involved in PA metabolism.

Expanding and Decoding the Chemistry of Phospholipid Headgroup in Eukaryotes

The paper develops a method to manipulate phospholipid headgroups and discovers their diverse biological effects across species.

Identification and Regulation of a Hepatic Lipogenic Metabolon

The paper identifies a hepatic lipogenic metabolon that enhances fatty acid and triglyceride synthesis through post-translational regulation, suggesting it as a therapeutic target for metabolic liver diseases.

Organelle-specific lipid profiles influence/underlie metabolic health in a nutrition-dependent manner

This study shows that dietary fat affects mitochondrial and lipid droplet lipid profiles in skeletal muscle, with specific lipid classes linked to metabolic health and insulin resistance.

Unsaturated Fatty Acids Are Required for Germline Proliferation and Membrane Structural Integrity in Caenorhabditis elegans

This study shows that unsaturated fatty acids are essential for germline proliferation, DNA replication, meiotic progression, and membrane integrity in C. elegans.

Cardiolipin Remodeling as a Regulatory Switch in Osteogenesis: Insights from Multimodal Metabolic Imaging and Molecular Profiling

This study investigates cardiolipin remodeling during osteogenesis using multimodal techniques, finding it links to mitochondrial function and bone matrix formation.

DGAT1-dependent lipid droplet synthesis in microglia attenuates neuroinflammatory responses to lipopolysaccharides.

This study shows DGAT1-dependent lipid droplet synthesis in microglia reduces pro-inflammatory cytokine production in response to LPS.

CLN8 enables a non-canonical phospholipid synthesis pathway

The paper describes a non-canonical phospholipid synthesis pathway catalyzed by CLN8, leading to BMP synthesis and revealing its role in lysosomal lipid homeostasis and Batten disease.

Lipid droplet-sphingolipid crosstalk regulates Doa1 activity and DNA damage response

This study shows that lipid droplets regulate DNA damage response by modulating Doa1 activity, linking lipid metabolism to genome stability and cellular aging.

Conserved lipid metabolic reprogramming confers hypoxic and aging resilience

This study identifies lipid metabolic reprogramming as a conserved mechanism conferring hypoxic and aging resilience in Arctic ground squirrels and C. elegans.

Sec14L6 is a PS and PI4P transporter that promotes lipid droplet formation

This study identifies Sec14L6 as a PS/PI4P transporter essential for lipid droplet formation by interacting with ACSL3 and being recruited to the ER via PGRMC1.

PII interactions with BADC and BCCP proteins co-regulate lipid and nitrogen metabolism in Arabidopsis

This study shows PII interacts with BADC and BCCP proteins to regulate lipid and nitrogen metabolism in Arabidopsis by modulating ACCase activity and protein stoichiometry.

Arabidopsis root lipid droplets are hubs for membrane homeostasis under heat stress, and triterpenoid synthesis and storage.

This study investigates the role of lipid droplets in Arabidopsis root cells under heat stress, finding they act as hubs for membrane homeostasis, triterpenoid synthesis, and storage.

DDHD2 possesses both lipase and transacylase capacities that remodel triglyceride acyl chains

This paper identifies DDHD2 as a neutral lipid lipase and transacylase that remodels triglyceride acyl chains by transferring acyl groups between lipids.

Organization of the Yeast Seipin Complex Reveals Differential Recruitment of Regulatory Proteins

The paper investigates the molecular architecture of the yeast seipin complex and its interaction with regulatory proteins under different metabolic conditions.

Comparative study of Dog and Human Lipid Droplet-associated protein (PLIN2)

This study compares the structural and functional characteristics of PLIN2 in dogs and humans, revealing both conservation and species-specific differences.

Selective Targeting of Kinesin on Lipid Droplets in the Liver Reduces Serum Lipids

The paper shows that targeting kinesin-1 on lipid droplets reduces serum lipids in cell culture and zebrafish, with no toxicity or lipid accumulation.

Architecture of an asymmetric mycobacterial short chain/long chain acyl-CoA carboxylase

The paper reveals the asymmetric architecture of a mycobacterial ACCase complex with distinct short-chain and long-chain acyl-CoA carboxyl transferase activities.

ATGL-mediated lipolysis is essential for myocellular mitochondrial function and augments PPARδ-induced improvements in mitochondrial respiration

The paper shows that ATGL-mediated lipolysis is essential for mitochondrial function and that PPARδ activation can improve mitochondrial respiration in myotubes with dysfunctional ATGL.

Seipin mediates Perilipin-1 recruitment to lipid droplets to preserve human adipocyte identity

This study shows seipin is essential for recruiting Perilipin-1 to lipid droplets in human adipocytes, maintaining adipocyte identity and preventing de-differentiation.

Adipogenin Dictates Adipose Tissue Expansion by Facilitating the Assembly of a Dodecameric Seipin Complex

This study identifies Adig as a regulator of lipid droplet formation by stabilizing the dodecameric seipin complex, leading to increased fat mass and thermogenesis in mice.

ORP5 controls the partitioning of phosphatidic acid between triacylglycerol and cardiolipin synthesis at mitochondria-ER-lipid droplet contact sites

This study identifies ORP5 as a key regulator of phosphatidic acid partitioning between triacylglycerol and cardiolipin synthesis at MAM-LD junctions, showing its role in balancing lipid metabolism and mitochondrial health.

Coordination of membrane synthesis with cell growth: the Escherichia coli phospholipid synthesis enzyme PlsB responds to membrane abundance in a manner consistent with filamentation-mediated inhibition

The paper shows that PlsB in E. coli forms inactive filaments in response to membrane abundance, coordinating phospholipid synthesis with cell growth.

The essential role of 2,4-dienoyl-CoA reductase for degradation of complex fatty acid mixtures

This paper shows that 2,4-dienoyl-CoA reductase (FadH) is essential for E. coli to degrade unsaturated fatty acids in complex mixtures and that eukaryotic DECR enzymes can functionally replace FadH.

Chain length defines the spatial segregation and metabolic fate of fatty acids in adipocytes

This study shows that short- and medium-chain fatty acids are preferentially oxidized within adipocytes rather than released, due to their distinct storage and mobilization dynamics compared to long-chain fatty acids.

Loss of PREPL alters lipid homeostasis due to mitochondrial defects

This study shows that PREPL deficiency causes mitochondrial dysfunction, leading to lipid accumulation and altered peroxisome morphology, but not direct lipid metabolism regulation.

The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility

The paper identifies Ldm1 and Ldo16 as actin-dependent lipid droplet motility mediators in yeast, showing their roles in LD movement and mitochondrial transport.

Decoupling of plastid and endomembrane homeoviscous response to low temperature and darkness in Phaeodactylum tricornutum

This study examines lipidomic changes in Phaeodactylum tricornutum under low temperature and darkness, revealing distinct adaptations in plastid and endomembrane lipids.

Identification of radical SAM enzymes responsible for the methylation and desaturation of archaeal lipids and an AttH hydratase mediating hydroxy-GDGT biosynthesis

This paper identifies novel radical SAM enzymes involved in archaeal lipid methylation, desaturation, and hydroxy-GDGT biosynthesis using three archaeal species.