M. Chen

Decoding Root Biogeography: Building Reduced Complexity Functional Rhizosphere Microbial Consortia

This study develops reduced complexity rhizosphere microbial consortia by enriching root-associated microbes from Brachypodium using carbon substrates, revealing their stability and functional roles in plant growth promotion.

Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex

The paper determines the cryo-EM structure of the human ULK1C core and its complex with PI3KC3-C1, revealing structural changes that suggest a mechanism for autophagy initiation through supercomplex formation.

Lipid Transfer Proteins and PI4KIIα Initiate Nuclear p53-Phosphoinositide Signaling

The paper identifies PITP/β and PI4KIIα as key regulators initiating nuclear p53-PIPn signaling through PI transfer and phosphorylation, with implications for cancer therapy.

Genetic basis of expression and splicing underlying spike architecture in wheat (Triticum aestivum L.)

This study identifies eQTLs and sQTLs associated with spike architecture in wheat, revealing genetic factors that regulate gene expression and splicing related to yield traits.

The translocation mechanism of calcitriol through Helicobacter pylori lipid membrane and influence on water permeability

This study investigates how calcitriol and cholesterol translocate through H. pylori lipid membranes and their effects on water permeability using molecular dynamics simulations.

Effect of growing regions on morphological characteristics, protein nutrition, rumen degradation and molecular structures of various whole-plant silage corn cultivars

Avirulent ME49Δgra5 Protecting Hosts Against Toxoplasma gondii Infection and Breast Tumors

This paper shows that the gra5 knockout T. gondii strain ME49Δgra5 is avirulent, prevents cyst formation, and protects against T. gondii infection and breast tumor growth in mice.

The Alfin-like transcription factor GmAlfin09 regulates endoplasmic reticulum stress in soybean via a peroxidase GmPRDX6

This study identifies GmAlfin09 as a transcription factor that enhances ER stress resistance in soybean by upregulating GmPRDX6, which reduces ROS levels and maintains ER homeostasis.

In situ structures of secretins from bacterial type II secretion system reveal their membrane interactions and translocation process

The paper determines in situ structures of GspD and GspDβ secretins during translocation, revealing distinct membrane interaction patterns and translocation mechanisms.

Analysis of gene expression heterogeneity reveals therapeutic targets and novel regulators of metastasis

The paper identifies therapeutic targets and novel metastasis regulators by analyzing gene expression heterogeneity in triple-negative breast cancer using single-cell RNA sequencing.

ABP1/ABL3-TMK1 cell-surface auxin signaling directly targets PIN2-mediated auxin fluxes for root gravitropism

The paper identifies a mechanism where auxin signaling via ABP1-TMK1 receptor module stabilizes PIN2 to reinforce asymmetric auxin flow for root gravitropism.

Caught in the Act: targeted mutagenesis of the herpesvirus fusogen central helix captures transition states

This study mutates the herpesvirus fusogen gB to capture its transition state, revealing the critical role of domain III in membrane fusion.

Cooperatively Designed Aptamer-PROTACs for Spatioselective Degradation of Nucleocytoplasmic Shuttling Protein for Enhanced Combinational Therapy

This paper introduces PS-ApTCs, a novel PROTAC design using aptamers for spatioselective degradation of nucleocytoplasmic shuttling proteins, showing enhanced efficacy and synergistic effects in cancer therapy.

Intermittent hypoxia therapy engages multiple longevity pathways to double lifespan in C.elegans

This study shows intermittent hypoxia therapy doubles C. elegans lifespan without HIF-1 but requires DAF-16/FOXO and other phosphatidylinositol signaling components.

Increased public health threat of avian-origin H3N2 influenza virus during evolution in dogs

This study identifies how avian-origin H3N2 influenza viruses adapt to dogs, acquiring traits that increase their potential to infect humans.

Emergency hematopoiesis proceeds without contribution of hematopoietic stem cells

This study shows that hematopoietic stem cells (HSCs) do not contribute to mature blood cell regeneration during common emergencies like inflammation or blood loss.

Chemoenzymatic Measurement of Cell-surface Glycan in Single-cell Multiomics: LacNAc as an Example

The paper introduces a chemoenzymatic method to detect cell-surface glycan in single-cell multiomics, showing increased LacNAc in activated CD8+ T cells and its correlation with glycolytic activity.

BCAA catabolism drives adipogenesis via an intermediate metabolite and promotes subcutaneous adipose tissue expansion during obesity

Fibronectin-integrin α5 signaling promotes thoracic aortic aneurysm in a mouse model of Marfan syndrome

This study shows that fibronectin-integrin α5 signaling drives thoracic aortic aneurysms in Marfan syndrome mice, with a 5/2 chimera mutation reducing aneurysm severity.

Isoform-specific Disruption of the TP73 Gene Reveals a Critical Role for TAp73gamma in Tumorigenesis via Leptin

This study shows that the p73{gamma}-Leptin pathway promotes tumorigenesis and alters lipid metabolism by demonstrating that E11 deletion increases p73{gamma} and Leptin, leading to oncogenic effects in mice and human cancers.

A multispecific antibody prevents immune escape and confers pan-SARS-CoV-2 neutralization

This paper develops multispecific antibodies that neutralize all SARS-CoV-2 variants, including Omicron, by targeting multiple epitopes on the spike protein.

Comparative analyses of the N-glycoproteomes in HCT116 cancer cells and their non-tumorigenic DNMT1/3b double knockout (DKO1) cells and insight into the Mannose-6-phosphate pathway

The paper compares N-glycoproteomes of HCT116 cancer cells and DKO1 non-tumorigenic cells, revealing hyper-M6P modification and its potential role in cancer biology.

A cross-scale analysis to understand and quantify effects of photosynthetic enhancement on crop growth and yield

The paper uses a cross-scale model to predict how photosynthetic manipulations affect wheat and sorghum yield across environments, finding modest gains with some strategies and challenges in scaling up.

Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation

This study identifies epsin-2 as a therapeutic target for multiple system atrophy by regulating FABP7/-synuclein hetero-aggregates propagation.

Transcriptomic analysis reveals hub genes and pathways in response to acetic acid stress in Kluyveromyces marxianus during high-temperature ethanol fermentation

This study identifies differentially expressed genes and pathways in Kluyveromyces marxianus under acetic acid stress during high-temperature ethanol fermentation, revealing effects on protein metabolism and ethanol production.

Nature's design of the osteochondral unit: microstructural differences between terrestrial and aquatic mammals

This study compares the microstructural organization and biomechanical properties of osteochondral units in marine and terrestrial mammals, finding significant differences in collagen fiber arrangement and cartilage stiffness.

Structural dynamics underlying gating and regulation in IP3R channel

The paper determines 3D structures of IP3R1 in two ligand-bound states using cryo-EM and identifies dynamic properties of key domains involved in ligand binding and channel gating.

Ratiometric NAD+ sensors reveal subcellular NAD+ modulators

The paper introduces NAD+ sensors to measure subcellular and clinical NAD+ dynamics, revealing NAD+ redistribution effects of -GPC in live cells.

An atlas of epithelial cell states and plasticity in lung adenocarcinoma

This study maps epithelial cell states and plasticity in lung adenocarcinoma using single-cell data, identifying KRT8+ alveolar intermediate cells linked to poor survival and tumorigenesis.

Metformin decreases Cyp26a1 to prevent hepatocarcinogenesis through down- regulating CD8+ T cells

This study shows metformin reduces Cyp26a1 expression, increasing atRA levels and decreasing pro-tumor CD8+ T cells, thereby preventing hepatocarcinogenesis in a mouse model.