W. Yu

An AI-assisted Tool For Efficient Prostate Cancer Diagnosis

This paper develops a deep learning pipeline to detect malignant glands in prostate cancer core needle biopsies, achieving high accuracy and providing heatmaps for pathologists.

Three-dimensional label-free histological imaging of whole organs by microtomy-assisted autofluorescence tomography

This paper introduces MATE, a label-free 3D histological imaging technique for whole organs, enabling high-resolution visualization and quantitative analysis of tissue structures without staining or clearing.

Rare Monoclonal Antibody Discovery Based on Indirect Competitive Screening of Single Hapten-specific Rabbit Antibody Secreting Cell

This paper introduces a method to discover rare rabbit monoclonal antibodies against small molecules using an indirect competitive screening approach, resulting in a highly stable antibody with exceptional halophilic properties.

Three-dimensional Multicolor Subcellular Imaging by Fast Serial Sectioning Tomography for Centimeter-scale Specimens

This paper introduces TRUST, a fast 3D imaging method for centimeter-scale specimens, enabling multicolor subcellular imaging without extensive sample preparation.

Different structures and pathologies of alpha-synuclein fibrils derived from preclinical and postmortem patients of Parkinson's disease

This study compares alpha-synuclein fibril structures from preclinical and postmortem Parkinson's disease patients, showing structural and pathological differences in fibril conformation during disease progression.

Cryo-ET distinguishes platelets during pre-acute myeloid leukemia from steady state hematopoiesis

The paper uses cryo-ET to identify structural changes in platelets during pre-acute myeloid leukemia, suggesting these changes could serve as an early diagnostic biomarker.

SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies

SARS-CoV-2 Beta variant infection generates lineage-specific antibodies and cross-reactive antibodies with neutralizing activity against wild-type and other variants.

Exploring ensemble structures of Alzheimer's amyloid β (1-42) monomer using linear regression for the MD simulation and NMR chemical shift

This paper uses linear regression with NMR and MD simulation data to determine ensemble structures of Alzheimer's Aβ monomers, revealing β-sheet and partially-helical conformations and their implications for amyloidogenesis.

A Framework for Automated Gene Selection in Genomic Screening

This paper proposes a framework for automated gene selection in genomic screening, creating gene lists with strong disease associations and demonstrating their utility in healthy genome screening.

Identifying Upper Airway and Evaluating Adenoid in Lateral Cephalometric Radiographs of Pediatric Patients Using Image-based Deep Learning Technique

This paper develops a deep learning system to assess upper airway obstruction and adenoid size in pediatric radiographs, achieving good segmentation performance and agreement with experts.

Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants

This paper develops a circular RNA vaccine encoding SARS-CoV-2 Spike RBD, showing broad protection against multiple variants including Delta and Omicron.

DFT and Raman study of all-trans astaxanthin optical isomers

This study uses Raman spectroscopy and DFT calculations to distinguish three optical isomers of all-trans astaxanthin based on differences in Raman band intensities.

Multi-antigen recognition circuits overcome challenges of specificity, heterogeneity, and durability in T cell therapy for glioblastoma

This study develops multiantigen recognition circuits for CAR T cells to improve specificity, heterogeneity, and durability in glioblastoma treatment.

Extracellular histones stimulate collagen expression and potentially promote liver fibrogenesis via TLR4-MyD88 signalling pathway

This study shows extracellular histones stimulate collagen production in liver fibrosis via TLR4-MyD88 signaling, and NAHP reduces fibrosis by neutralizing histones.

Single-cell multi-omics reveals elevated plasticity and stem-cell-like blasts relevant to the poor prognosis of KMT2A-rearranged leukemia

This study uses single-cell multi-omics to identify lineage plasticity and stem-cell-like blasts in KMT2A-rearranged leukemia, linking these features to poor prognosis in infants.

Salmonella subverts autophagy balancing bacterial fate and cellular inflammation

This study identifies c-MYC as a negative regulator of Salmonella Typhimurium cytosolic lifestyle and shows how LC3 and SopF modulate SCV stability to balance bacterial survival and host inflammation.

Aryl hydrocarbon receptor and TGF-β inducible early gene mediate a transcriptional axis modulating immune homeostasis in mosquitoes

This study identifies AhR and TIEG as a transcriptional axis modulating immune homeostasis in mosquitoes, showing their roles in immune response regulation through gene networks involving sugar metabolism and circadian rhythms.

Structural basis of a public antibody response to SARS-CoV-2

The paper identifies IGHV3-53 as a common VH gene for SARS-CoV-2 neutralizing antibodies and determines its structural basis for binding the RBD.

Bone marrow adipogenic lineage precursors (MALPs) promote osteoclastogenesis in bone remodeling and pathologic bone loss

This study identifies marrow adipogenic lineage precursors (MALPs) as critical regulators of osteoclastogenesis through RANKL expression, showing their role in both normal bone remodeling and pathologic bone loss.

Genome-Wide Mapping of Cisplatin Damaged Gene Loci

This study maps cisplatin-damaged gene loci and identifies key pathways and targets, revealing SPAG9 as a potential therapeutic target for testicular cancer.

Fusarium verticillioides FvPex8 is a key component of peroxisomal docking/translocation module that serves important roles in fumonisin biosynthesis but not in virulence

Susceptibility of tree shrew to SARS-CoV-2 infection

This study investigates tree shrew susceptibility to SARS-CoV-2 infection and finds that they show mild symptoms and low viral replication, suggesting limited susceptibility.

Mico-Community associated with ectomycorrhizal Russula symbiosis and sporocarp-producing Russula in Fagaceae dominant nature areas in southern China

The study identifies microbial communities associated with ECM Russula symbiosis and sporocarp production in Fagaceae plants in southern China.

Comparison of SARS-CoV-2 infections among 3 species of non-human primates

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

A bacterial effector protein prevents MAPK-mediated phosphorylation of SGT1 to suppress plant immunity

This study identifies RipAC, a bacterial effector that inhibits SGT1 phosphorylation by blocking its interaction with MAPKs, thereby suppressing plant immunity.

Neutralizing PD-L1 and PD-L2 Enhances the Efficacy of Immune Checkpoint Inhibitors in Ovarian Cancer.

The paper develops a high-affinity sPD-1 decoy molecule that neutralizes both PD-L1 and PD-L2, showing superior antitumor activity in ovarian cancer models compared to PD-1/PD-L1 antibodies.

Intra-strain elicitation and suppression of plant immunity by Ralstonia solanacearum type-III effectors in Nicotiana benthamiana

This study investigates how Ralstonia solanacearum uses effector proteins to elicit and suppress plant immunity in Nicotiana benthamiana.

SIRT2-knockdown Rescues GARS-induced Charcot-Marie-Tooth Neuropathy

This study shows that reducing SIRT2 rescues GARS-induced neuropathy in a Drosophila model by restoring acetylated tubulin levels and axonal transport.

Structure of the cell-binding component of the Clostridium difficile binary toxin reveals a novel macromolecular assembly

This paper determines the atomic structures of the C. difficile binary toxin CDTb using cryoEM and X-ray crystallography, revealing novel di-heptamer forms and critical domains for toxicity and stability.

FvLcp1, a type-D fungal LysM protein with Chitin-binding domains, is a secreted protein involved in host recognition and fumonisin production in Fusarium verticillioides - maize kernel interaction

This paper identifies FvLcp1, a secreted type-D fungal LysM protein with chitin-binding domains, as a key factor in fumonisin production and host recognition in F. verticillioides during maize infection.